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. 1992 May 1;283(Pt 3):661–664. doi: 10.1042/bj2830661

Antizyme, a protein induced by polyamines, accelerates the degradation of ornithine decarboxylase in Chinese-hamster ovary-cell extracts.

Y Murakami 1, K Tanaka 1, S Matsufuji 1, Y Miyazaki 1, S Hayashi 1
PMCID: PMC1130936  PMID: 1590755

Abstract

Ornithine decarboxylase (ODC), the key regulatory enzyme for polyamine biosynthesis, is known to have a short intracellular half-life, and antizyme, an ODC-binding protein induced by polyamines, has been suggested to be involved in the process of ODC degradation. In the present study we demonstrated that antizyme markedly accelerated ATP-dependent degradation of ODC in vitro in an extract from ODC-overproducing Chinese-hamster ovary cells.

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Selected References

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