Table 1.

VEGF-A, ANG-2, or FGF-2 exerts EMT-associated, pro-tumor activities.

DIRECT EFFECT	VEGF-A	ANG-2	FGF-2
Triggering of AKT or MAPK	Yes [100]	Yes [101,102,103]	Yes [104,105,106,107]
Activation of TWIST, SNAI, or ZEB	Yes [108]	Not known	Yes [91,109,110]
Downregulation of E-cadherin expression	Yes [19,108,111]	Yes [34]	Yes [112]
Induction of N-cadherin expression	Yes [108]	Not known	Yes [113]
Induction of vimentin expression	Yes [108]	Yes [44]	Yes [114]
Induction of fibronectin expression	No [36,115]	Not known	Yes [113,116]
Upregulation of MMP-1	Yes [117]	Yes [118]	Yes [119]
Upregulation of MT1-MMP, MMP-2, and MMP-9	Yes [120,121,122,123,124,125,126,127,128]	Yes [129]	Yes [128,130,131,132]
Downregulation of TIMP-1	Yes [133]	Yes [133]	Yes [134]
Protection from anoikis	Yes [135,136]	Not known	Yes [137]
Promotion of CSCs appearance and viability	Yes [138,139]	Not known	Yes [138,139,140]