In the original publication [1], there was a mistake in Table 3 as published. The table contained some identical values in several groups in some lines of Table 3. The corrected Table 3 appears below. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor.
Table 3.
Hemodynamic results.
| Cohort | Normoxic Cohort: | Hypoxic Cohort: | ||||||
|---|---|---|---|---|---|---|---|---|
| Group (n) |
N-Ctrl (9–14) |
N-PZ (6–7) |
N-PR (6–8) |
N-PZ + PR (6–8) |
H-Ctrl (14–16) |
H-PZ (9–13) |
H-PR (7–12) |
H-PZ + PR (9) |
| EF [%] | 56.9 ± 1.8 | 48.8 ± 1.7 ## | ||||||
| 61.8 ± 1.2 | 62.6 ± 1.5 | 49.5 ± 5.6 * | 50.7 ± 4.3 * | 54.1 ± 2.9 # | 45.9 ± 2.5 ## * | 42.7 ± 4.2 * | 48.4 ± 3.4 | |
| SW [mmHg µL] |
15,001 ± 1146 | 10,954 ± 664 ## | ||||||
| 18512 ± 2174 | 16857 ± 1104 | 12476 ± 1560 * | 10467 ± 1532 *** | 12852 ± 1513 ## | 9577 ± 939 ## | 9151 ± 1164 | 11830 ± 1095 | |
| HR [min−1] | 426.0 ± 7.7 | 390.0 ± 6.2 ### | ||||||
| 441.8 ± 8.1 | 458.1 ± 11.2 | 423.9 ± 9.3 | 374.5 ± 21.1 *** | 410.4 ± 8.3 # | 407.4 ± 11.1 ## | 359.6 ± 11.9 ### *** | 367.7 ± 13.9 ** | |
| LV esE [mmHg/µL] |
0.33 (0.26; 0.50) | 0.36 (0.24; 0.71) | ||||||
| 0.36 (0.24; 0.53) |
0.28 (0.26; 0.34) |
0.44 (0.37; 0.55) |
0.24 (0.17; 0.50) |
0.34 (0.26; 0.66) |
0.57 (0.28; 0.76) |
0.33 (0.25; 0.58) |
0.25 (0.18; 0.72) |
|
| RV dP/dtmax [mmHg/s] |
2053 (1602; 2488) | 1919 (1530; 2687) | ||||||
| 2154 (2072; 2448) |
2441 (2001; 3233) |
1888 (1609; 3348) |
1473 (1390; 1719) |
2511 (1823; 3118) |
2238 (1799; 3049) |
1568 (1503; 1919) |
1402 (1158; 1631) * |
|
| RV dP/dtmin [mmHg/s] |
−1711 (−2145; −1215) | −1618 (−2138; −1274) | ||||||
| −1896 (−2501; −1727) |
−1863 (−2164; −1166) |
−1409 (−1774; −1228) |
−1208 (−1454; −1053) |
−2088 (−2384; −1487) |
−1856 (−2291; −1236) |
−1379 (−1681; −1077) |
−1333 (−1778; −1098) |
|
| MAP [mmHg] | 96.4 ± 3.5 | 91.0 ± 2.4 | ||||||
| 109.6 ± 3.5 | 91.0 ± 5.7 | 92.7 ± 11.6 | 84.7 ± 5.0 | 91.4 ± 3.6 | 91.2 ± 4.8 | 87.1 ± 5.9 | 95.2 ± 5.7 | |
| TPR [mmHg min kg s−1] | 0.28 (0.25; 0.33) | 0.31 (0.29; 0.41) # | ||||||
| 0.28 (0.25; 0.32) |
0.25 (0.24; 0.28) |
0.28 (0.23; 0.46) |
0.31 (0.26; 0.38) |
0.30 (0.25; 0.33) |
0.30 (0.27; 0.46) |
0.33 (0.30; 0.43) |
0.40 (0.30; 0.51) |
|
Normally distributed data are given as means ± SEM; if data were not normally distributed, the medians (25th; 75th percentiles) are presented (n = number of values per group). Cohort means (± SEM) and medians (25th; 75th percentiles) are presented in bold characters. Cohort/group labels: N = normoxia; H = hypoxia; Ctrl = control group (0.9% saline infusion); PZ = prazosin; PR = propranolol. LV, RV = left/right ventricle; EF = ejection fraction; esE = end-systolic elastance; SW = stroke work; dP/dt max = maximal velocity of contraction; dP/dt min = maximal velocity of relaxation; HR = heart rate; MAP = mean aortic pressure; TPR = total peripheral resistance. Significant differences from the hypoxic cohort or groups to the normoxic cohort or to the corresponding normoxic group: # p < 0.05; ## p < 0.01; ### p < 0.001; significant differences between blocker groups and the related control (N-Ctrl or H-Ctrl) are marked with asterisks: * p < 0.05; ** p < 0.01; *** p < 0.001.
Footnotes
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Reference
- 1.Neubert E., Rassler B., Hoschke A., Raffort C., Salameh A. Effects of Normobaric Hypoxia and Adrenergic Blockade over 72 h on Cardiac Function in Rats. Int. J. Mol. Sci. 2023;24:11417. doi: 10.3390/ijms241411417. [DOI] [PMC free article] [PubMed] [Google Scholar]