Figure 4: Global bacteriocin T8 prevalence increases over time and is associated with emergent lineages.

(A) Geographic distribution of 15,631 global VREfm isolates across continents; EU: Europe, NA: North America, AUS: Australia, AS: Asia, and AF: Africa. Isolates are colored by sequence type (ST). (B) Global ST distribution between 2002–2022. Isolates are colored by ST. (C) Abundance of bacteriocin T8 within main STs. Bars are separated into emergent and historical lineages based on trends seen within the UPMC collection (Fig. S3). Bacteriocin T8 presence is shaded in burgundy and absence in grey. (D) Prevalence of bacteriocin T8 over time at UPMC (burgundy) and in the global collection (light burgundy).