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. 1990 May 15;268(1):35–40. doi: 10.1042/bj2680035

Flow cytometry resonance energy transfer suggests an association between low-affinity interleukin 2 binding sites and HLA class I molecules.

A Harel-Bellan 1, P Krief 1, L Rimsky 1, W L Farrar 1, Z Mishal 1
PMCID: PMC1131387  PMID: 2111701

Abstract

Using flow cytometry energy transfer we have studied the sterical proximity of interleukin 2 receptors and the heavy chain of the major histocompatibility complex at the surface of normal lymphocytes. Our data suggest that class I molecules may be part of a low-affinity interleukin 2 receptor multimolecular complex, where the MHC class I heavy chain is in close proximity to the actual interleukin 2 binding site, in contrast to the light chain (beta 2-microglobulin).

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Selected References

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