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. 1990 Jul 15;269(2):531–534. doi: 10.1042/bj2690531

Age-related changes in glutathione synthesis in the eye lens.

J V Ferrer 1, E Gascó 1, J Sastre 1, F V Pallardó 1, M Asensi 1, J Viña 1
PMCID: PMC1131610  PMID: 2386490

Abstract

Eye lenses from young rats or mice synthesize GSH from methionine or N-acetylcysteine. However, lenses from old animals do not synthesize GSH from methionine. This is due to the absence of cystathionase activity in old lenses. GSH monoethyl ester, but not free GSH, increases GSH content and protects the lens against experimental oxidative stress. The importance of these results in the prevention of cataractogenesis is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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