Table 7.

(a) Analysis of indirect effects at baseline of the mediators diabetes and hypertension in the association between body mass index and moderately increased albuminuria of 6508 participants of the Netherlands Epidemiology of Obesity (NEO). (b) Analysis of indirect effects at baseline of the mediators diabetes and hypertension in the association between total body fat and moderately increased albuminuria of 6477 participants of the Netherlands Epidemiology of Obesity (NEO)

(a)
		% of Total Effect	95% CI
Indirect effecta through:
Diabetesb alone		6.0	1.5 to 10.6
Hypertensionc alone		19.2	7.8 to 30.6
Diabetes + Hypertension	Diabetes	4.4	0.2 to 8.6
	Hypertension	18.9	7.3 to 30.6

(b)
Indirect effecta through:
Diabetesb alone		6.2	0.8 to 11.5
Hypertensionc alone		19.0	5.9 to 32.1
Diabetes + Hypertension	Diabetes	4.5	−0.1 to 9.2
	Hypertension	19.0	5.5 to 32.5

Results were based on analyses weighted towards the BMI distribution of the general population and were derived from multiplied path coefficients with 95% confidence intervals from general structural equation modeling (path analysis) and expressed as indirect effects in the association between body mass index (kg/m²) and moderately increased albuminuria (defined as urine albumin-to-creatinine ratio ≥2.5 mg/mmol in men and ≥3.5 mg/mmol in women) (7a) or expressed as indirect effects in the association between total body fat (%) and moderately increased albuminuria (7b). Indirect effects were divided by total effects to calculate the percentage mediated.

CI confidence interval

^aIndirect effects were adjusted for sex, age, smoking, ethnicity, physical activity and Dutch Healthy Diet index

^bDiabetes mellitus is considered present in case of a self-reported physician’s diagnosis and/or use of glucose lowering drugs or fasting glucose levels ≥ 7 mmol/L

^cSystolic blood pressure ≥ 140 mmHg and/or the diastolic blood pressure ≥ 90 mmHg or use of antihypertensive drugs