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. 1990 Sep 15;270(3):645–649. doi: 10.1042/bj2700645

Fructose 2,6-bisphosphate and 6-phosphofructo-2-kinase during liver regeneration.

J L Rosa 1, F Ventura 1, J Carreras 1, R Bartrons 1
PMCID: PMC1131780  PMID: 2173548

Abstract

Glycogen and fructose 2,6-bisphosphate levels in rat liver decreased quickly after partial hepatectomy. After 7 days the glycogen level was normalized and fructose 2,6-bisphosphate concentration still remained low. The 'active' (non-phosphorylated) form of 6-phosphofructo-2-kinase varied in parallel with fructose 2,6-bisphosphate levels, whereas the 'total' activity of the enzyme decreased only after 24 h, similarly to glucokinase. The response of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase from hepatectomized rats (96 h) to sn-glycerol 3-phosphate and to cyclic AMP-dependent protein kinase was different from that of the enzyme from control animals and similar to that of the foetal isoenzyme.

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Selected References

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