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. 1990 Sep 15;270(3):833–836. doi: 10.1042/bj2700833

Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat.

R G Knowles 1, M Merrett 1, M Salter 1, S Moncada 1
PMCID: PMC1131810  PMID: 1700698

Abstract

Nitric oxide (NO) synthase in rat brain was found to be constitutive and Ca2(+)-dependent. The enzyme in rat lung or liver (predominantly in parenchymal cells) was not constitutive, but was induced by endotoxin treatment and was Ca2(+)-independent. The NO synthases in rat brain and liver or lung are therefore distinct both in their properties and in their regulation.

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Selected References

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