Abstract
The study investigated plasma clearance of exogenous creatinine (PECCT), exo-iohexol (PexICT) and endo-iohexol (PenICT) in six healthy cats, four cats with chronic kidney disease (CKD) and six hyperthyroid (HT) cats to assess potential differences in glomerular filtration rate (GFR) measurement over a wide range of GFR values. The PECCT, PexICT and PenICT were performed in a combined protocol. There was a significant difference between PexICT and PenICT and PECCT in healthy cats. Differences between clearance techniques are suggested to be correlated to range in GFRs and should be taken into account when GFR is measured.
Contributor Information
Ingrid M. van Hoek, Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, University of Ghent, Salisburylaan 133, 9820 Merelbeke, Belgium
Hervé P. Lefebvre, Department of Clinical Sciences and UMR181 de Physiopathologie et Toxicologie Expérimentales INRA, ENVT, École Nationale Vétérinaire de Toulouse, 23 Chemin des Capelles, BP 87614, 31076 Toulouse Cedex 3, France
Dominique Paepe, Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, University of Ghent, Salisburylaan 133, 9820 Merelbeke, Belgium.
Siska Croubels, Department of Pharmacology, Toxicology, Biochemistry and Organ Physiology, Faculty of Veterinary Medicine, University of Ghent, Salisburylaan 133, 9820 Merelbeke, Belgium.
Vincent Biourge, Royal Canin, Centre de Recherche, 650 Avenue de la Petite Camargue, 30470 Aimargues, France.
Sylvie Daminet, Department of Medicine and Clinical Biology of Small Animals, Faculty of Veterinary Medicine, University of Ghent, Salisburylaan 133, 9820 Merelbeke, Belgium.
References
- DiBartola S.P.Textbook of veterinary internal medicine. Ettinger S.J., Feldman E.C., ed. Philadelphia: WB Saunders; 2000:1600-1614. [Google Scholar]
- Polzin D.J.,Osborne C.A.,Ross S.Textbook of veterinary internal medicine. Ettinger S.J., Feldman E., ed. St Louis: Elsevier Saunders; 2005:1756-1785. [Google Scholar]
- Laroute V.,Lefebvre H.P.,Costes G.,Toutain P.L..Measurement of glomerular filtration rate and effective renal plasma flow in the conscious beagle dog by single intravenous bolus of iohexol and p-aminohippuric acid.J Pharmacol Toxicol Methods. 1999;41:17-25 [DOI] [PubMed] [Google Scholar]
- van Hoek I.,Vandermeulen E.,Duchateau L., et al.Comparison and reproducibility of plasma clearance of exogenous creatinine, exo-iohexol, endo-iohexol, and 51Cr-EDTA in young adult and aged healthy cats.J Vet Intern Med. 2007;21:950-958 [DOI] [PubMed] [Google Scholar]
- van Hoek I.,Lefebvre H.,Kooistra H., et al.Plasma clearance of exogenous creatinine, exo-iohexol and endo-iohexol in hyperthyroid cats before and after treatment with radioiodine.J Vet Intern Med. 2008;22:879-885 [DOI] [PubMed] [Google Scholar]
- Le Garrérès A.,Laroute V.,De La Farge F.,Boudet K.G.,Lefebvre H.P..Disposition of plasma creatinine in non-azotaemic and moderately azotaemic cats.J Feline Med Surg. 2007;9:89-96 [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brown S.A.,Finco D.R.,Boudinot F.D.,Wright J.,Taver S.L.,Cooper T..Evaluation of a single injection method, using iohexol, for estimating glomerular filtration rate in cats and dogs.Am J Vet Res. 1996;57:105-110 [PubMed] [Google Scholar]
- Brown S.A.,Haberman C.,Finco D.R..Use of plasma clearance of inulin for estimating glomerular filtration rate in cats.Am J Vet Res. 1996;57:1702-1705 [PubMed] [Google Scholar]
- Miyamoto K..Evaluation of plasma clearance of inulin in clinically normal and partially nephrectomized cats.Am J Vet Res. 2001;62:1332-1335 [DOI] [PubMed] [Google Scholar]
- Miyamoto K..Use of plasma clearance of iohexol for estimating glomerular filtration rate in cats.Am J Vet Res. 2001;62:572-575 [DOI] [PubMed] [Google Scholar]
- Ross L.A.,Finco D.R..Relationship of selected clinical renal function tests to glomerular filtration rate and renal blood flow in cats.Am J Vet Res. 1981;42:1704-1710 [PubMed] [Google Scholar]
- McClellan J.M.,Goldstein R.E.,Erb H.N.,Dykes N.L.,Cowgill L.D..Effects of administration of fluids and diuretics on glomerular filtration rate, renal blood flow, and urine output in healthy awake cats.Am J Vet Res. 2006;67:715-722 [DOI] [PubMed] [Google Scholar]