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. 1993 Jan 15;289(Pt 2):373–377. doi: 10.1042/bj2890373

Changes in free cytoplasmic magnesium following activation of human lymphocytes.

G T Rijkers 1, A W Griffioen 1
PMCID: PMC1132177  PMID: 8424782

Abstract

Activation of lymphocytes with 10 microM ionomycin leads to a rapid increase in the concentration of free cytoplasmic calcium ([Ca2+]i) and, at a slower rate, also to an increase in the cytoplasmic free magnesium concentration ([Mg2+]i). The ionomycin-induced Mg(2+)-mobilization response is dependent on the influx of extracellular Ca2+. After receptor-mediated lymphocyte activation, induced by mitogens or anti-receptor antibodies, a Mg(2+)-mobilization response does occur in a small fraction of the cells. Simultaneous measurement of [Ca2+]i and [Mg2+]i in individual cells showed that the receptor-triggered Mg(2+)-mobilization response is restricted to cells that have a high [Ca2+]i. It can therefore be concluded that a high [Ca2+]i induces the release into the cytoplasm of Mg2+ from intracellular stores.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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