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Biochemical Journal logoLink to Biochemical Journal
. 1993 Jan 15;289(Pt 2):557–560. doi: 10.1042/bj2890557

Regulation of cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase mRNA levels by L-tri-iodothyronine.

T Royo 1, D Haro 1, F G Hegardt 1
PMCID: PMC1132204  PMID: 8093833

Abstract

In hypophysectomized and thyroidectomized rats, cytosolic 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase activity, immunoreactive protein and mRNA levels were all considerably decreased. Administration of L-tri-iodothyronine (T3) resulted in a large increase in all three in hypophysectomized rats and in only a 2-fold increase (reaching the values of control rats) in thyroidectomized rats.

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Selected References

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