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. 1993 Feb 1;289(Pt 3):783–788. doi: 10.1042/bj2890783

New patterns of diacylglycerol metabolism in intact cells.

J Florin-Christensen 1, M Florin-Christensen 1, J M Delfino 1, H Rasmussen 1
PMCID: PMC1132244  PMID: 8435076

Abstract

The metabolism of di[1-14C]octanoylglycerol metabolism was examined in four cell lines: NIH 3T3 fibroblasts, BHK cells, Pam 212 keratinocytes and WEHI 3BD+ cells. We found the direct conversion of 1,2-di[1-14C]octanoyl-sn-glycerol ([14C]diC8) into dioctanoylphosphatidylcholine and dioctanoylacylglycerol, but no formation of phosphatidylinositol. The [14C]diC8 also underwent lipolytic breakdown. In contrast, 1-[1-14C]oleoyl-2-acetyl-sn-glycerol was metabolized exclusively by lipolysis. Our findings support a new scheme for the metabolic termination of diacylglycerol signals.

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Selected References

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