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. 1993 Apr 1;291(Pt 1):205–210. doi: 10.1042/bj2910205

On the role of the C-terminus of alpha-calcitonin-gene-related peptide (alpha CGRP). The structure of des-phenylalaninamide37-alpha CGRP and its interaction with the CGRP receptor.

J P O'Connell 1, S M Kelly 1, D P Raleigh 1, J A Hubbard 1, N C Price 1, C M Dobson 1, B J Smith 1
PMCID: PMC1132503  PMID: 8385932

Abstract

alpha-Calcitonin-gene-related peptide (alpha CGRP) lacking its C-terminal phenylalaninamide residue was found not to bind to its receptor as did full-length (amidated) alpha CGRP. Investigation of the structure of these peptides by c.d. and n.m.r. revealed no significant difference, so it seemed that the effect of deleting the C-terminal phenylalaninamide on the biological activity of alpha CGRP was not by disruption of the peptide's structure. Thus the C-terminal phenylalaninamide is an important factor in this ligand-receptor interaction, and the group itself may interact directly with the receptor.

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Selected References

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