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. 1993 Apr 15;291(Pt 2):623–625. doi: 10.1042/bj2910623

Different N-terminal forms of alpha 2-plasmin inhibitor in human plasma.

K Bangert 1, A H Johnsen 1, U Christensen 1, S Thorsen 1
PMCID: PMC1132569  PMID: 8484741

Abstract

Mature alpha 2-plasmin inhibitor in human plasma has 12 more N-terminal residues than hitherto anticipated. The first residue is the methionine at position 28, downstream from the N-terminus of the pre-protein. The cDNA sequence predicts that the site cleaved upon formation of the mature inhibitor is a typical signal-peptidase recognition site. The mature inhibitor (464 residues) and the previously reported, and presumably degraded, form with N-terminal asparagine (452 residues), are present in plasma in about equal amounts. They both form a stable complex with plasmin. Recent studies on a recombinant alpha 2-plasmin inhibitor suggest that the 12 additional residues have functional implications [Sumi, Ichikawa, Nakamura, Miura and Aoki (1989) J. Biochem. 106, 703-707].

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Selected References

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