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. 1992 Jun 15;284(Pt 3):625–628. doi: 10.1042/bj2840625

Stimulation of NADH oxidase activity from rat liver plasma membranes by growth factors and hormones is decreased or absent with hepatoma plasma membranes.

M Bruno 1, A O Brightman 1, J Lawrence 1, D Werderitsh 1, D M Morré 1, D J Morre 1
PMCID: PMC1132580  PMID: 1622384

Abstract

Plasma membranes of rat liver isolated by aqueous two-phase partition exhibited basal levels of NADH oxidase activity that were increased approx. 2-fold by addition of hormones and growth factors to which liver cells were known to respond. In contrast, hepatoma plasma membranes demonstrated an intrinsically increased level of NADH oxidase, which was not stimulated further by addition of growth factors. The results suggest that the NADH oxidase of the hepatoma plasma membrane is no longer correctly coupled to hormone and growth-factor receptors. This biochemical defect may parallel the loss of growth control that is characteristic of neoplastic transformation in hepatocarcinogenesis and other transformation systems.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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