Fig 6. MLH1-E34A and MLH1-RADA fail to promote polar resolution of sequence divergence during RMDs.

(A) Shown is the frequency of top strand base retention for WT, Mlh1^−/−, Mlh1^−/− + MLH1 (WT), Mlh1^−/− + E34A mESCs. WT samples as in Fig 2B. n=3. *p ≤ 0.05, **p ≤ 0.005, p*** ≤ 0.001. WT vs. Mlh1^−/−, unpaired t-test, Mlh1^−/− vs. Mlh1^−/− + MLH1 (WT) and Mlh1^−/− + E34A, unpaired t-tests with Holm-Sidak correction. (B) Frequency of top strand base retention for WT, Mlh1^−/−, Mlh1^−/− + MLH1 (WT), Mlh1^−/− + RADA mESCs. WT samples as in Fig 2B. n=3. *p ≤ 0.05, **p ≤ 0.005, *** ≤ 0.001. WT vs. Mlh1^−/−, unpaired t-test, Mlh1^−/− vs. Mlh1^−/− + MLH1 (WT) and Mlh1^−/− + RADA, unpaired t-tests with Holm-Sidak correction. Data are represented as mean values ± SD.