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. 1992 Jul 15;285(Pt 2):477–480. doi: 10.1042/bj2850477

A potentiometric titration study of the interaction of heparin with metal cations.

D Grant 1, W F Long 1, F B Williamson 1
PMCID: PMC1132812  PMID: 1637338

Abstract

Potentiometric titrations, at ionic strengths (I) ranging from 0.0057 to 0.336, suggest that Ca2+, Cu2+, Li+ and Na+ bind to heparin in a manner that depends on cation identity. These interactions were less affected by the value of I than those of heparin with Mg2+, which binds weakly below I0.050 and with K+, which binds weakly at I0.0057. Of the interactions studied, that of heparin with Cu2+ was the least readily reversible.

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Selected References

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