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. 1992 Aug 15;286(Pt 1):5–8. doi: 10.1042/bj2860005

Rat surfactant protein D enhances the production of oxygen radicals by rat alveolar macrophages.

J F Van Iwaarden 1, H Shimizu 1, P H Van Golde 1, D R Voelker 1, L M Van Golde 1
PMCID: PMC1133009  PMID: 1325783

Abstract

Rat surfactant protein D (SP-D) was shown to enhance the production of oxygen radicals by rat alveolar macrophages. This enhancement, which was determined by a lucigenin-dependent chemiluminescence assay, was maximal after 18 min at an SP-D concentration of 0.2 micrograms/ml. Surfactant lipids did not influence the stimulation of alveolar macrophages by SP-D, whereas the oxygen-radical production of these cells induced by surfactant protein A was inhibited by the lipids in a concentration-dependent manner.

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Selected References

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