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. 1992 Oct 15;287(Pt 2):337–347. doi: 10.1042/bj2870337

Regulation of the synthesis, processing and translocation of lipoprotein lipase.

J E Braun 1, D L Severson 1
PMCID: PMC1133170  PMID: 1445192

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ailhaud G. Cellular and secreted lipoprotein lipase revisited. Clin Biochem. 1990 Oct;23(5):343–347. doi: 10.1016/0009-9120(90)90034-r. [DOI] [PubMed] [Google Scholar]
  2. Al-Jafari A. A., Cryer A. The lipoprotein lipase of white adipose tissue. Changes in the adipocyte cell-surface content of enzyme in response to extracellular effectors in vitro. Biochem J. 1986 Aug 15;238(1):239–246. doi: 10.1042/bj2380239. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Ameis D., Kobayashi J., Davis R. C., Ben-Zeev O., Malloy M. J., Kane J. P., Lee G., Wong H., Havel R. J., Schotz M. C. Familial chylomicronemia (type I hyperlipoproteinemia) due to a single missense mutation in the lipoprotein lipase gene. J Clin Invest. 1991 Apr;87(4):1165–1170. doi: 10.1172/JCI115114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Balch W. E. Biochemistry of interorganelle transport. A new frontier in enzymology emerges from versatile in vitro model systems. J Biol Chem. 1989 Oct 15;264(29):16965–16968. [PubMed] [Google Scholar]
  5. Beg O. U., Meng M. S., Skarlatos S. I., Previato L., Brunzell J. D., Brewer H. B., Jr, Fojo S. S. Lipoprotein lipaseBethesda: a single amino acid substitution (Ala-176----Thr) leads to abnormal heparin binding and loss of enzymic activity. Proc Natl Acad Sci U S A. 1990 May;87(9):3474–3478. doi: 10.1073/pnas.87.9.3474. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Beisiegel U., Weber W., Bengtsson-Olivecrona G. Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8342–8346. doi: 10.1073/pnas.88.19.8342. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ben-Zeev O., Doolittle M. H., Davis R. C., Elovson J., Schotz M. C. Maturation of lipoprotein lipase. Expression of full catalytic activity requires glucose trimming but not translocation to the cis-Golgi compartment. J Biol Chem. 1992 Mar 25;267(9):6219–6227. [PubMed] [Google Scholar]
  8. Ben-Zeev O., Doolittle M. H., Singh N., Chang C. H., Schotz M. C. Synthesis and regulation of lipoprotein lipase in the hippocampus. J Lipid Res. 1990 Jul;31(7):1307–1313. [PubMed] [Google Scholar]
  9. Bensadoun A. Lipoprotein lipase. Annu Rev Nutr. 1991;11:217–237. doi: 10.1146/annurev.nu.11.070191.001245. [DOI] [PubMed] [Google Scholar]
  10. Bienkowski R. S. Intracellular degradation of newly synthesized secretory proteins. Biochem J. 1983 Jul 15;214(1):1–10. doi: 10.1042/bj2140001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Blanchette-Mackie E. J., Masuno H., Dwyer N. K., Olivecrona T., Scow R. O. Lipoprotein lipase in myocytes and capillary endothelium of heart: immunocytochemical study. Am J Physiol. 1989 Jun;256(6 Pt 1):E818–E828. doi: 10.1152/ajpendo.1989.256.6.E818. [DOI] [PubMed] [Google Scholar]
  12. Borensztajn J., Robinson D. S. The effect of fasting on the utilization of chylomicron triglyceride fatty acids in relation to clearing factor lipase (lipoprotein lipase) releasable by heparin in the perfused rat heart. J Lipid Res. 1970 Mar;11(2):111–117. [PubMed] [Google Scholar]
  13. Braun J. E., Severson D. L. Diabetes reduces heparin- and phospholipase C-releasable lipoprotein lipase from cardiomyocytes. Am J Physiol. 1991 Mar;260(3 Pt 1):E477–E485. doi: 10.1152/ajpendo.1991.260.3.E477. [DOI] [PubMed] [Google Scholar]
  14. Braun J. E., Severson D. L. Lipoprotein lipase release from cardiac myocytes is increased by decavanadate but not insulin. Am J Physiol. 1992 May;262(5 Pt 1):E663–E670. doi: 10.1152/ajpendo.1992.262.5.E663. [DOI] [PubMed] [Google Scholar]
  15. Breckenridge W. C., Little J. A., Steiner G., Chow A., Poapst M. Hypertriglyceridemia associated with deficiency of apolipoprotein C-II. N Engl J Med. 1978 Jun 8;298(23):1265–1273. doi: 10.1056/NEJM197806082982301. [DOI] [PubMed] [Google Scholar]
  16. Brion C., Miller S. G., Moore H. P. Regulated and constitutive secretion. Differential effects of protein synthesis arrest on transport of glycosaminoglycan chains to the two secretory pathways. J Biol Chem. 1992 Jan 25;267(3):1477–1483. [PubMed] [Google Scholar]
  17. Brändli A. W. Mammalian glycosylation mutants as tools for the analysis and reconstitution of protein transport. Biochem J. 1991 May 15;276(Pt 1):1–12. doi: 10.1042/bj2760001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Camps L., Gåfvels M., Reina M., Wallin C., Vilaró S., Olivecrona T. Expression of lipoprotein lipase in ovaries of the guinea pig. Biol Reprod. 1990 May-Jun;42(5-6):917–927. doi: 10.1095/biolreprod42.6.917. [DOI] [PubMed] [Google Scholar]
  19. Camps L., Reina M., Llobera M., Bengtsson-Olivecrona G., Olivecrona T., Vilaró S. Lipoprotein lipase in lungs, spleen, and liver: synthesis and distribution. J Lipid Res. 1991 Dec;32(12):1877–1888. [PubMed] [Google Scholar]
  20. Camps L., Reina M., Llobera M., Vilaró S., Olivecrona T. Lipoprotein lipase: cellular origin and functional distribution. Am J Physiol. 1990 Apr;258(4 Pt 1):C673–C681. doi: 10.1152/ajpcell.1990.258.4.C673. [DOI] [PubMed] [Google Scholar]
  21. Carneheim C., Nedergaard J., Cannon B. Cold-induced beta-adrenergic recruitment of lipoprotein lipase in brown fat is due to increased transcription. Am J Physiol. 1988 Feb;254(2 Pt 1):E155–E161. doi: 10.1152/ajpendo.1988.254.2.E155. [DOI] [PubMed] [Google Scholar]
  22. Chajek-Shaul T., Bengtsson-Olivecrona G., Peterson J., Olivecrona T. Metabolic fate of rat heart endothelial lipoprotein lipase. Am J Physiol. 1988 Sep;255(3 Pt 1):E247–E254. doi: 10.1152/ajpendo.1988.255.3.E247. [DOI] [PubMed] [Google Scholar]
  23. Chajek-Shaul T., Friedman G., Knobler H., Stein O., Etienne J., Stein Y. Importance of the different steps of glycosylation for the activity and secretion of lipoprotein lipase in rat preadipocytes studied with monensin and tunicamycin. Biochim Biophys Acta. 1985 Nov 14;837(2):123–134. doi: 10.1016/0005-2760(85)90235-8. [DOI] [PubMed] [Google Scholar]
  24. Chajek-Shaul T., Halimi O., Ben-Naim M., Stein O., Stein Y. Phosphatidylinositol-specific phospholipase C releases lipoprotein lipase from the heparin releasable pool in rat heart cell cultures. Biochim Biophys Acta. 1989 Nov 20;1014(2):178–183. doi: 10.1016/0167-4889(89)90031-1. [DOI] [PubMed] [Google Scholar]
  25. Chajek T., Stein O., Stein Y. Lipoprotein lipase of cultured mesenchymal rat heart cells. I. Synthesis, secretion and releasability by heparin. Biochim Biophys Acta. 1978 Mar 30;528(3):456–465. doi: 10.1016/0005-2760(78)90035-8. [DOI] [PubMed] [Google Scholar]
  26. Chan B. L., Lisanti M. P., Rodriguez-Boulan E., Saltiel A. R. Insulin-stimulated release of lipoprotein lipase by metabolism of its phosphatidylinositol anchor. Science. 1988 Sep 23;241(4873):1670–1672. doi: 10.1126/science.241.4873.1670. [DOI] [PubMed] [Google Scholar]
  27. Chen Y. D., Howard J., Huang V., Kraemer F. B., Reaven G. M. Dissociation between plasma triglyceride concentration and tissue lipoprotein lipase deficiency in insulin-deficient rats. Diabetes. 1980 Aug;29(8):643–647. doi: 10.2337/diab.29.8.643. [DOI] [PubMed] [Google Scholar]
  28. Cheng C. F., Oosta G. M., Bensadoun A., Rosenberg R. D. Binding of lipoprotein lipase to endothelial cells in culture. J Biol Chem. 1981 Dec 25;256(24):12893–12898. [PubMed] [Google Scholar]
  29. Chohan P., Cryer A. Lipoprotein lipase activity of rat cardiac muscle. Changes in the enzyme activity during incubations of isolated cardiac-muscle cells in vitro. Biochem J. 1980 Mar 15;186(3):873–879. doi: 10.1042/bj1860873. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Chohan P., Cryer A. The lipoprotein lipase (clearing-factor lipase) activity of cells isolated from rat cardiac muscle. Biochem J. 1978 Aug 15;174(2):663–666. doi: 10.1042/bj1740663. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Cisar L. A., Hoogewerf A. J., Cupp M., Rapport C. A., Bensadoun A. Secretion and degradation of lipoprotein lipase in cultured adipocytes. Binding of lipoprotein lipase to membrane heparan sulfate proteoglycans is necessary for degradation. J Biol Chem. 1989 Jan 25;264(3):1767–1774. [PubMed] [Google Scholar]
  32. Cooper D. A., Stein J. C., Strieleman P. J., Bensadoun A. Avian adipose lipoprotein lipase: cDNA sequence and reciprocal regulation of mRNA levels in adipose and heart. Biochim Biophys Acta. 1989 Jun 1;1008(1):92–101. doi: 10.1016/0167-4781(89)90174-7. [DOI] [PubMed] [Google Scholar]
  33. Cupp M., Bensadoun A., Melford K. Heparin decreases the degradation rate of lipoprotein lipase in adipocytes. J Biol Chem. 1987 May 5;262(13):6383–6388. [PubMed] [Google Scholar]
  34. Davis R. C., Ben-Zeev O., Martin D., Doolittle M. H. Combined lipase deficiency in the mouse. Evidence of impaired lipase processing and secretion. J Biol Chem. 1990 Oct 15;265(29):17960–17966. [PubMed] [Google Scholar]
  35. Deeb S. S., Peng R. L. Structure of the human lipoprotein lipase gene. Biochemistry. 1989 May 16;28(10):4131–4135. doi: 10.1021/bi00436a001. [DOI] [PubMed] [Google Scholar]
  36. Doolittle M. H., Ben-Zeev O., Elovson J., Martin D., Kirchgessner T. G. The response of lipoprotein lipase to feeding and fasting. Evidence for posttranslational regulation. J Biol Chem. 1990 Mar 15;265(8):4570–4577. [PubMed] [Google Scholar]
  37. Eckel R. H. Lipoprotein lipase. A multifunctional enzyme relevant to common metabolic diseases. N Engl J Med. 1989 Apr 20;320(16):1060–1068. doi: 10.1056/NEJM198904203201607. [DOI] [PubMed] [Google Scholar]
  38. Elbein A. D. Glycosidase inhibitors: inhibitors of N-linked oligosaccharide processing. FASEB J. 1991 Dec;5(15):3055–3063. doi: 10.1096/fasebj.5.15.1743438. [DOI] [PubMed] [Google Scholar]
  39. Elbein A. D. Inhibitors of the biosynthesis and processing of N-linked oligosaccharide chains. Annu Rev Biochem. 1987;56:497–534. doi: 10.1146/annurev.bi.56.070187.002433. [DOI] [PubMed] [Google Scholar]
  40. Emi M., Wilson D. E., Iverius P. H., Wu L., Hata A., Hegele R., Williams R. R., Lalouel J. M. Missense mutation (Gly----Glu188) of human lipoprotein lipase imparting functional deficiency. J Biol Chem. 1990 Apr 5;265(10):5910–5916. [PubMed] [Google Scholar]
  41. Enerbäck S., Semb H., Bengtsson-Olivecrona G., Carlsson P., Hermansson M. L., Olivecrona T., Bjursell G. Molecular cloning and sequence analysis of cDNA encoding lipoprotein lipase of guinea pig. Gene. 1987;58(1):1–12. doi: 10.1016/0378-1119(87)90023-0. [DOI] [PubMed] [Google Scholar]
  42. Enerbäck S., Semb H., Tavernier J., Bjursell G., Olivecrona T. Tissue-specific regulation of guinea pig lipoprotein lipase; effects of nutritional state and of tumor necrosis factor on mRNA levels in adipose tissue, heart and liver. Gene. 1988 Apr 15;64(1):97–106. doi: 10.1016/0378-1119(88)90484-2. [DOI] [PubMed] [Google Scholar]
  43. Fager G., Semb H., Enerbäck S., Olivecrona T., Jonasson L., Bengtsson-Olivecrona G., Camejo G., Bjursell G., Bondjers G. Hyperlipoproteinemia type I in a patient with active lipoprotein lipase in adipose tissue and indications of defective transport of the enzyme. J Lipid Res. 1990 Jul;31(7):1187–1197. [PubMed] [Google Scholar]
  44. Faustinella F., Smith L. C., Semenkovich C. F., Chan L. Structural and functional roles of highly conserved serines in human lipoprotein lipase. Evidence that serine 132 is essential for enzyme catalysis. J Biol Chem. 1991 May 25;266(15):9481–9485. [PubMed] [Google Scholar]
  45. Fried S. K., Turkenkopf I. J., Goldberg I. J., Doolittle M. H., Kirchgessner T. G., Schotz M. C., Johnson P. R., Greenwood M. R. Mechanisms of increased lipoprotein lipase in fat cells of obese Zucker rats. Am J Physiol. 1991 Nov;261(5 Pt 1):E653–E660. doi: 10.1152/ajpendo.1991.261.5.E653. [DOI] [PubMed] [Google Scholar]
  46. Friedman G., Chajek-Shaul T., Etienne J., Stein O., Stein Y. Tunicamycin-treated rat heart cell cultures synthesize an inactive nonreleasable lipoprotein lipase. Biochim Biophys Acta. 1988 Jun 15;960(3):455–457. doi: 10.1016/0005-2760(88)90054-9. [DOI] [PubMed] [Google Scholar]
  47. Fuhrmann U., Bause E., Ploegh H. Inhibitors of oligosaccharide processing. Biochim Biophys Acta. 1985 Jun 24;825(2):95–110. doi: 10.1016/0167-4781(85)90095-8. [DOI] [PubMed] [Google Scholar]
  48. Gallagher J. T., Lyon M., Steward W. P. Structure and function of heparan sulphate proteoglycans. Biochem J. 1986 Jun 1;236(2):313–325. doi: 10.1042/bj2360313. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Garfinkel A. S., Kempner E. S., Ben-Zeev O., Nikazy J., James S. J., Schotz M. C. Lipoprotein lipase: size of the functional unit determined by radiation inactivation. J Lipid Res. 1983 Jun;24(6):775–780. [PubMed] [Google Scholar]
  50. Giménez-Llort L., Vilanova J., Skottova N., Bengtsson-Olivecrona G., Llobera M., Robert M. Q. Lipoprotein lipase enables triacylglycerol hydrolysis by perfused newborn rat liver. Am J Physiol. 1991 Oct;261(4 Pt 1):G641–G647. doi: 10.1152/ajpgi.1991.261.4.G641. [DOI] [PubMed] [Google Scholar]
  51. Giralt M., Martin I., Vilaró S., Villarroya F., Mampel T., Iglesias R., Viñas O. Lipoprotein lipase mRNA expression in brown adipose tissue: translational and/or posttranslational events are involved in the modulation of enzyme activity. Biochim Biophys Acta. 1990 Apr 6;1048(2-3):270–273. doi: 10.1016/0167-4781(90)90066-b. [DOI] [PubMed] [Google Scholar]
  52. Goldberg I. J., Soprano D. R., Wyatt M. L., Vanni T. M., Kirchgessner T. G., Schotz M. C. Localization of lipoprotein lipase mRNA in selected rat tissues. J Lipid Res. 1989 Oct;30(10):1569–1577. [PubMed] [Google Scholar]
  53. Graves R. A., Tontonoz P., Spiegelman B. M. Analysis of a tissue-specific enhancer: ARF6 regulates adipogenic gene expression. Mol Cell Biol. 1992 Mar;12(3):1202–1208. doi: 10.1128/mcb.12.3.1202. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Green H., Kehinde O. Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells. Cell. 1976 Jan;7(1):105–113. doi: 10.1016/0092-8674(76)90260-9. [DOI] [PubMed] [Google Scholar]
  55. Green H., Meuth M. An established pre-adipose cell line and its differentiation in culture. Cell. 1974 Oct;3(2):127–133. doi: 10.1016/0092-8674(74)90116-0. [DOI] [PubMed] [Google Scholar]
  56. Gåfvels M., Vilaró S., Olivecrona T. Lipoprotein lipase in guinea-pig adrenals: activity, mRNA, immunolocalization and regulation by ACTH. J Endocrinol. 1991 May;129(2):213–220. doi: 10.1677/joe.0.1290213. [DOI] [PubMed] [Google Scholar]
  57. Hamosh M., Hamosh P. Lipoprotein lipase: its physiological and clinical significance. Mol Aspects Med. 1983;6(3):199–289. doi: 10.1016/0098-2997(83)90006-7. [DOI] [PubMed] [Google Scholar]
  58. Henderson H. E., Ma Y., Hassan M. F., Monsalve M. V., Marais A. D., Winkler F., Gubernator K., Peterson J., Brunzell J. D., Hayden M. R. Amino acid substitution (Ile194----Thr) in exon 5 of the lipoprotein lipase gene causes lipoprotein lipase deficiency in three unrelated probands. Support for a multicentric origin. J Clin Invest. 1991 Jun;87(6):2005–2011. doi: 10.1172/JCI115229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Hide W. A., Chan L., Li W. H. Structure and evolution of the lipase superfamily. J Lipid Res. 1992 Feb;33(2):167–178. [PubMed] [Google Scholar]
  60. Holm C., Kirchgessner T. G., Svenson K. L., Fredrikson G., Nilsson S., Miller C. G., Shively J. E., Heinzmann C., Sparkes R. S., Mohandas T. Hormone-sensitive lipase: sequence, expression, and chromosomal localization to 19 cent-q13.3. Science. 1988 Sep 16;241(4872):1503–1506. doi: 10.1126/science.3420405. [DOI] [PubMed] [Google Scholar]
  61. Hoogewerf A. J., Bensadoun A. Occurrence of sulfate in an asparagine-linked complex oligosaccharide of chicken adipose lipoprotein lipase. J Biol Chem. 1991 Jan 15;266(2):1048–1057. [PubMed] [Google Scholar]
  62. Howard B. V. Lipoprotein metabolism in diabetes mellitus. J Lipid Res. 1987 Jun;28(6):613–628. [PubMed] [Google Scholar]
  63. Iverius P. H., Ostlund-Lindqvist A. M. Lipoprotein lipase from bovine milk. Isolation procedure, chemical characterization, and molecular weight analysis. J Biol Chem. 1976 Dec 25;251(24):7791–7795. [PubMed] [Google Scholar]
  64. Jackson R. L., Busch S. J., Cardin A. D. Glycosaminoglycans: molecular properties, protein interactions, and role in physiological processes. Physiol Rev. 1991 Apr;71(2):481–539. doi: 10.1152/physrev.1991.71.2.481. [DOI] [PubMed] [Google Scholar]
  65. Jensen D. R., Bessesen D. H., Etienne J., Eckel R. H., Neville M. C. Distribution and source of lipoprotein lipase in mouse mammary gland. J Lipid Res. 1991 May;32(5):733–742. [PubMed] [Google Scholar]
  66. Kirchgessner T. G., Chuat J. C., Heinzmann C., Etienne J., Guilhot S., Svenson K., Ameis D., Pilon C., d'Auriol L., Andalibi A. Organization of the human lipoprotein lipase gene and evolution of the lipase gene family. Proc Natl Acad Sci U S A. 1989 Dec;86(24):9647–9651. doi: 10.1073/pnas.86.24.9647. [DOI] [PMC free article] [PubMed] [Google Scholar]
  67. Kirchgessner T. G., LeBoeuf R. C., Langner C. A., Zollman S., Chang C. H., Taylor B. A., Schotz M. C., Gordon J. I., Lusis A. J. Genetic and developmental regulation of the lipoprotein lipase gene: loci both distal and proximal to the lipoprotein lipase structural gene control enzyme expression. J Biol Chem. 1989 Jan 25;264(3):1473–1482. [PubMed] [Google Scholar]
  68. Kirchgessner T. G., Svenson K. L., Lusis A. J., Schotz M. C. The sequence of cDNA encoding lipoprotein lipase. A member of a lipase gene family. J Biol Chem. 1987 Jun 25;262(18):8463–8466. [PubMed] [Google Scholar]
  69. Komaromy M. C., Schotz M. C. Cloning of rat hepatic lipase cDNA: evidence for a lipase gene family. Proc Natl Acad Sci U S A. 1987 Mar;84(6):1526–1530. doi: 10.1073/pnas.84.6.1526. [DOI] [PMC free article] [PubMed] [Google Scholar]
  70. Ladu M. J., Kapsas H., Palmer W. K. Regulation of lipoprotein lipase in adipose and muscle tissues during fasting. Am J Physiol. 1991 May;260(5 Pt 2):R953–R959. doi: 10.1152/ajpregu.1991.260.5.R953. [DOI] [PubMed] [Google Scholar]
  71. Lisanti M. P., Rodriguez-Boulan E., Saltiel A. R. Emerging functional roles for the glycosyl-phosphatidylinositol membrane protein anchor. J Membr Biol. 1990 Jul;117(1):1–10. doi: 10.1007/BF01871561. [DOI] [PubMed] [Google Scholar]
  72. Liu G. Q., Olivecrona T. Pulse-chase study on lipoprotein lipase in perfused guinea pig heart. Am J Physiol. 1991 Dec;261(6 Pt 2):H2044–H2050. doi: 10.1152/ajpheart.1991.261.6.H2044. [DOI] [PubMed] [Google Scholar]
  73. Low M. G. Glycosyl-phosphatidylinositol: a versatile anchor for cell surface proteins. FASEB J. 1989 Mar;3(5):1600–1608. doi: 10.1096/fasebj.3.5.2522071. [DOI] [PubMed] [Google Scholar]
  74. Low M. G. The glycosyl-phosphatidylinositol anchor of membrane proteins. Biochim Biophys Acta. 1989 Dec 6;988(3):427–454. doi: 10.1016/0304-4157(89)90014-2. [DOI] [PubMed] [Google Scholar]
  75. Maley F., Trimble R. B., Tarentino A. L., Plummer T. H., Jr Characterization of glycoproteins and their associated oligosaccharides through the use of endoglycosidases. Anal Biochem. 1989 Aug 1;180(2):195–204. doi: 10.1016/0003-2697(89)90115-2. [DOI] [PubMed] [Google Scholar]
  76. Masuno H., Blanchette-Mackie E. J., Chernick S. S., Scow R. O. Synthesis of inactive nonsecretable high mannose-type lipoprotein lipase by cultured brown adipocytes of combined lipase-deficient cld/cld mice. J Biol Chem. 1990 Jan 25;265(3):1628–1638. [PubMed] [Google Scholar]
  77. Masuno H., Schultz C. J., Park J. W., Blanchette-Mackie E. J., Mateo C., Scow R. O. Glycosylation, activity and secretion of lipoprotein lipase in cultured brown adipocytes of newborn mice. Effect of tunicamycin, monensin, 1-deoxymannojirimycin and swainsonine. Biochem J. 1991 Aug 1;277(Pt 3):801–809. doi: 10.1042/bj2770801. [DOI] [PMC free article] [PubMed] [Google Scholar]
  78. Mellman I., Simons K. The Golgi complex: in vitro veritas? Cell. 1992 Mar 6;68(5):829–840. doi: 10.1016/0092-8674(92)90027-A. [DOI] [PMC free article] [PubMed] [Google Scholar]
  79. Monsalve M. V., Henderson H., Roederer G., Julien P., Deeb S., Kastelein J. J., Peritz L., Devlin R., Bruin T., Murthy M. R. A missense mutation at codon 188 of the human lipoprotein lipase gene is a frequent cause of lipoprotein lipase deficiency in persons of different ancestries. J Clin Invest. 1990 Sep;86(3):728–734. doi: 10.1172/JCI114769. [DOI] [PMC free article] [PubMed] [Google Scholar]
  80. Négrel R., Grimaldi P., Ailhaud G. Establishment of preadipocyte clonal line from epididymal fat pad of ob/ob mouse that responds to insulin and to lipolytic hormones. Proc Natl Acad Sci U S A. 1978 Dec;75(12):6054–6058. doi: 10.1073/pnas.75.12.6054. [DOI] [PMC free article] [PubMed] [Google Scholar]
  81. O'Looney P., Irwin D., Briscoe P., Vahouny G. V. Lipoprotein composition as a component in the lipoprotein clearance defect in experimental diabetes. J Biol Chem. 1985 Jan 10;260(1):428–432. [PubMed] [Google Scholar]
  82. O'Looney P., Vander Maten M., Vahouny G. V. Insulin-mediated modifications of myocardial lipoprotein lipase and lipoprotein metabolism. J Biol Chem. 1983 Nov 10;258(21):12994–13001. [PubMed] [Google Scholar]
  83. Oka K., Tkalcevic G. T., Nakano T., Tucker H., Ishimura-Oka K., Brown W. V. Structure and polymorphic map of human lipoprotein lipase gene. Biochim Biophys Acta. 1990 May 24;1049(1):21–26. doi: 10.1016/0167-4781(90)90079-h. [DOI] [PubMed] [Google Scholar]
  84. Olivecrona T., Chernick S. S., Bengtsson-Olivecrona G., Garrison M., Scow R. O. Synthesis and secretion of lipoprotein lipase in 3T3-L1 adipocytes. Demonstration of inactive forms of lipase in cells. J Biol Chem. 1987 Aug 5;262(22):10748–10759. [PubMed] [Google Scholar]
  85. Olivecrona T., Chernick S. S., Bengtsson-Olivecrona G., Paterniti J. R., Jr, Brown W. V., Scow R. O. Combined lipase deficiency (cld/cld) in mice. Demonstration that an inactive form of lipoprotein lipase is synthesized. J Biol Chem. 1985 Feb 25;260(4):2552–2557. [PubMed] [Google Scholar]
  86. Ong J. M., Kern P. A. Effect of feeding and obesity on lipoprotein lipase activity, immunoreactive protein, and messenger RNA levels in human adipose tissue. J Clin Invest. 1989 Jul;84(1):305–311. doi: 10.1172/JCI114155. [DOI] [PMC free article] [PubMed] [Google Scholar]
  87. Ong J. M., Kern P. A. The role of glucose and glycosylation in the regulation of lipoprotein lipase synthesis and secretion in rat adipocytes. J Biol Chem. 1989 Feb 25;264(6):3177–3182. [PubMed] [Google Scholar]
  88. Ong J. M., Kirchgessner T. G., Schotz M. C., Kern P. A. Insulin increases the synthetic rate and messenger RNA level of lipoprotein lipase in isolated rat adipocytes. J Biol Chem. 1988 Sep 15;263(26):12933–12938. [PubMed] [Google Scholar]
  89. Paterniti J. R., Jr, Brown W. V., Ginsberg H. N., Artzt K. Combined lipase deficiency (cld): a lethal mutation on chromosome 17 of the mouse. Science. 1983 Jul 8;221(4606):167–169. doi: 10.1126/science.6857276. [DOI] [PubMed] [Google Scholar]
  90. Pedersen M. E., Cohen M., Schotz M. C. Immunocytochemical localization of the functional fraction of lipoprotein lipase in the perfused heart. J Lipid Res. 1983 May;24(5):512–521. [PubMed] [Google Scholar]
  91. Pelham H. R. Control of protein exit from the endoplasmic reticulum. Annu Rev Cell Biol. 1989;5:1–23. doi: 10.1146/annurev.cb.05.110189.000245. [DOI] [PubMed] [Google Scholar]
  92. Persson B., Bengtsson-Olivecrona G., Enerbäck S., Olivecrona T., Jörnvall H. Structural features of lipoprotein lipase. Lipase family relationships, binding interactions, non-equivalence of lipase cofactors, vitellogenin similarities and functional subdivision of lipoprotein lipase. Eur J Biochem. 1989 Jan 15;179(1):39–45. doi: 10.1111/j.1432-1033.1989.tb14518.x. [DOI] [PubMed] [Google Scholar]
  93. Peterson J., Bihain B. E., Bengtsson-Olivecrona G., Deckelbaum R. J., Carpentier Y. A., Olivecrona T. Fatty acid control of lipoprotein lipase: a link between energy metabolism and lipid transport. Proc Natl Acad Sci U S A. 1990 Feb;87(3):909–913. doi: 10.1073/pnas.87.3.909. [DOI] [PMC free article] [PubMed] [Google Scholar]
  94. Pradines-Figueres A., Vannier C., Ailhaud G. Short-term stimulation by insulin of lipoprotein lipase secretion in adipose cells. Biochem Biophys Res Commun. 1988 Aug 15;154(3):982–990. doi: 10.1016/0006-291x(88)90236-7. [DOI] [PubMed] [Google Scholar]
  95. Pradines-Figuères A., Vannier C., Ailhaud G. Lipoprotein lipase stored in adipocytes and muscle cells is a cryptic enzyme. J Lipid Res. 1990 Aug;31(8):1467–1476. [PubMed] [Google Scholar]
  96. Previato L., Parrott C. L., Santamarina-Fojo S., Brewer H. B., Jr Transcriptional regulation of the human lipoprotein lipase gene in 3T3-L1 adipocytes. J Biol Chem. 1991 Oct 5;266(28):18958–18963. [PubMed] [Google Scholar]
  97. Raynolds M. V., Awald P. D., Gordon D. F., Gutierrez-Hartmann A., Rule D. C., Wood W. M., Eckel R. H. Lipoprotein lipase gene expression in rat adipocytes is regulated by isoproterenol and insulin through different mechanisms. Mol Endocrinol. 1990 Sep;4(9):1416–1422. doi: 10.1210/mend-4-9-1416. [DOI] [PubMed] [Google Scholar]
  98. Rodrigues B., Spooner M., Severson D. L. Free fatty acids do not release lipoprotein lipase from isolated cardiac myocytes or perfused hearts. Am J Physiol. 1992 Feb;262(2 Pt 1):E216–E223. doi: 10.1152/ajpendo.1992.262.2.E216. [DOI] [PubMed] [Google Scholar]
  99. Rojas C., Enerbäck S., Bengtsson-Olivecrona G. Synthesis and secretion of active lipoprotein lipase in Chinese-hamster ovary (CHO) cells. Biochem J. 1990 Oct 1;271(1):11–15. doi: 10.1042/bj2710011. [DOI] [PMC free article] [PubMed] [Google Scholar]
  100. Rose J. K., Doms R. W. Regulation of protein export from the endoplasmic reticulum. Annu Rev Cell Biol. 1988;4:257–288. doi: 10.1146/annurev.cb.04.110188.001353. [DOI] [PubMed] [Google Scholar]
  101. Rothman J. E., Orci L. Molecular dissection of the secretory pathway. Nature. 1992 Jan 30;355(6359):409–415. doi: 10.1038/355409a0. [DOI] [PubMed] [Google Scholar]
  102. Rothman J. E., Orci L. Movement of proteins through the Golgi stack: a molecular dissection of vesicular transport. FASEB J. 1990 Mar;4(5):1460–1468. doi: 10.1096/fasebj.4.5.2407590. [DOI] [PubMed] [Google Scholar]
  103. Rupp E., Mayer H., Wingender E. The promoter of the human parathyroid hormone gene contains a functional cyclic AMP-response element. Nucleic Acids Res. 1990 Oct 11;18(19):5677–5683. doi: 10.1093/nar/18.19.5677. [DOI] [PMC free article] [PubMed] [Google Scholar]
  104. Saxena U., Goldberg I. J. Interaction of lipoprotein lipase with glycosaminoglycans and apolipoprotein C-II: effects of free-fatty-acids. Biochim Biophys Acta. 1990 Apr 2;1043(2):161–168. doi: 10.1016/0005-2760(90)90291-5. [DOI] [PubMed] [Google Scholar]
  105. Saxena U., Klein M. G., Goldberg I. J. Identification and characterization of the endothelial cell surface lipoprotein lipase receptor. J Biol Chem. 1991 Sep 15;266(26):17516–17521. [PubMed] [Google Scholar]
  106. Saxena U., Klein M. G., Goldberg I. J. Metabolism of endothelial cell-bound lipoprotein lipase. Evidence for heparan sulfate proteoglycan-mediated internalization and recycling. J Biol Chem. 1990 Aug 5;265(22):12880–12886. [PubMed] [Google Scholar]
  107. Saxena U., Klein M. G., Goldberg I. J. Transport of lipoprotein lipase across endothelial cells. Proc Natl Acad Sci U S A. 1991 Mar 15;88(6):2254–2258. doi: 10.1073/pnas.88.6.2254. [DOI] [PMC free article] [PubMed] [Google Scholar]
  108. Saxena U., Witte L. D., Goldberg I. J. Release of endothelial cell lipoprotein lipase by plasma lipoproteins and free fatty acids. J Biol Chem. 1989 Mar 15;264(8):4349–4355. [PubMed] [Google Scholar]
  109. Schneider W. J., Carroll R., Severson D. L., Nimpf J. Apolipoprotein VLDL-II inhibits lipolysis of triglyceride-rich lipoproteins in the laying hen. J Lipid Res. 1990 Mar;31(3):507–513. [PubMed] [Google Scholar]
  110. Schotz M. C., Twu J. S., Pedersen M. E., Chen C. H., Garfinkel A. S., Borensztajn J. Antibodies to lipoprotein lipase. Application to perfused heart. Biochim Biophys Acta. 1977 Nov 24;489(2):214–224. doi: 10.1016/0005-2760(77)90140-0. [DOI] [PubMed] [Google Scholar]
  111. Semb H., Olivecrona T. Lipoprotein lipase in guinea pig tissues: molecular size and rates of synthesis. Biochim Biophys Acta. 1986 Oct 3;878(3):330–337. doi: 10.1016/0005-2760(86)90240-7. [DOI] [PubMed] [Google Scholar]
  112. Semb H., Olivecrona T. Mechanisms for turnover of lipoprotein lipase in guinea pig adipocytes. Biochim Biophys Acta. 1987 Sep 4;921(1):104–115. doi: 10.1016/0005-2760(87)90176-7. [DOI] [PubMed] [Google Scholar]
  113. Semb H., Olivecrona T. Nutritional regulation of lipoprotein lipase in guinea pig tissues. Biochim Biophys Acta. 1986 Apr 15;876(2):249–255. doi: 10.1016/0005-2760(86)90281-x. [DOI] [PubMed] [Google Scholar]
  114. Semb H., Olivecrona T. The relation between glycosylation and activity of guinea pig lipoprotein lipase. J Biol Chem. 1989 Mar 5;264(7):4195–4200. [PubMed] [Google Scholar]
  115. Semb H., Olivecrona T. Two different mechanisms are involved in nutritional regulation of lipoprotein lipase in guinea-pig adipose tissue. Biochem J. 1989 Sep 1;262(2):505–511. doi: 10.1042/bj2620505. [DOI] [PMC free article] [PubMed] [Google Scholar]
  116. Semenkovich C. F., Chen S. H., Wims M., Luo C. C., Li W. H., Chan L. Lipoprotein lipase and hepatic lipase mRNA tissue specific expression, developmental regulation, and evolution. J Lipid Res. 1989 Mar;30(3):423–431. [PubMed] [Google Scholar]
  117. Semenkovich C. F., Luo C. C., Nakanishi M. K., Chen S. H., Smith L. C., Chan L. In vitro expression and site-specific mutagenesis of the cloned human lipoprotein lipase gene. Potential N-linked glycosylation site asparagine 43 is important for both enzyme activity and secretion. J Biol Chem. 1990 Apr 5;265(10):5429–5433. [PubMed] [Google Scholar]
  118. Semenkovich C. F., Wims M., Noe L., Etienne J., Chan L. Insulin regulation of lipoprotein lipase activity in 3T3-L1 adipocytes is mediated at posttranscriptional and posttranslational levels. J Biol Chem. 1989 May 25;264(15):9030–9038. [PubMed] [Google Scholar]
  119. Senda M., Oka K., Brown W. V., Qasba P. K., Furuichi Y. Molecular cloning and sequence of a cDNA coding for bovine lipoprotein lipase. Proc Natl Acad Sci U S A. 1987 Jul;84(13):4369–4373. doi: 10.1073/pnas.84.13.4369. [DOI] [PMC free article] [PubMed] [Google Scholar]
  120. Severson D. L., Lee M., Carroll R. Secretion of lipoprotein lipase from myocardial cells isolated from adult rat hearts. Mol Cell Biochem. 1988 Jan;79(1):17–24. doi: 10.1007/BF00229393. [DOI] [PubMed] [Google Scholar]
  121. Shimada K., Gill P. J., Silbert J. E., Douglas W. H., Fanburg B. L. Involvement of cell surface heparin sulfate in the binding of lipoprotein lipase to cultured bovine endothelial cells. J Clin Invest. 1981 Oct;68(4):995–1002. doi: 10.1172/JCI110354. [DOI] [PMC free article] [PubMed] [Google Scholar]
  122. Sparkes R. S., Zollman S., Klisak I., Kirchgessner T. G., Komaromy M. C., Mohandas T., Schotz M. C., Lusis A. J. Human genes involved in lipolysis of plasma lipoproteins: mapping of loci for lipoprotein lipase to 8p22 and hepatic lipase to 15q21. Genomics. 1987 Oct;1(2):138–144. doi: 10.1016/0888-7543(87)90005-x. [DOI] [PubMed] [Google Scholar]
  123. Speake B. K., Parkin S. M., Robinson D. S. Degradation of lipoprotein lipase in rat adipose tissue. Biochim Biophys Acta. 1985 Jul 5;840(3):419–422. doi: 10.1016/0304-4165(85)90223-5. [DOI] [PubMed] [Google Scholar]
  124. Speake B. K., Parkinson C., Robinson D. S. The effect of insulin on the synthesis of lipoprotein lipase in rat adipose tissue. Horm Metab Res. 1985 Dec;17(12):637–640. doi: 10.1055/s-2007-1013632. [DOI] [PubMed] [Google Scholar]
  125. Spiro R. G., Spiro M. J., Bhoyroo V. D. Studies on the regulation of the biosynthesis of glucose-containing oligosaccharide-lipids. Effect of energy deprivation. J Biol Chem. 1983 Aug 10;258(15):9469–9476. [PubMed] [Google Scholar]
  126. Spooner P. M., Chernick S. S., Garrison M. M., Scow R. O. Insulin regulation of lipoprotein lipase activity and release in 3T3-L1 adipocytes. Separation and dependence of hormonal effects on hexose metabolism and synthesis of RNA and protein. J Biol Chem. 1979 Oct 25;254(20):10021–10029. [PubMed] [Google Scholar]
  127. Stein O., Stein Y., Schwartz S. P., Reshef A., Chajek-Shaul T., Ben-Naim M., Friedman G., Leitersdorf E. Expression of lipoprotein lipase mRNA in rat heart is localized mainly to mesenchymal cells as studied by in situ hybridization. Arterioscler Thromb. 1991 Jul-Aug;11(4):857–863. doi: 10.1161/01.atv.11.4.857. [DOI] [PubMed] [Google Scholar]
  128. Stray N., Letnes H., Blomhoff J. P. Intracellular regulation of lipoprotein lipase in human monocyte-derived macrophages. Biochim Biophys Acta. 1990 Aug 6;1045(3):280–284. doi: 10.1016/0005-2760(90)90131-g. [DOI] [PubMed] [Google Scholar]
  129. Tavangar K., Murata Y., Patel S., Kalinyak J. E., Pedersen M. E., Goers J. F., Hoffman A. R., Kraemer F. B. Developmental regulation of lipoprotein lipase in rats. Am J Physiol. 1992 Mar;262(3 Pt 1):E330–E337. doi: 10.1152/ajpendo.1992.262.3.E330. [DOI] [PubMed] [Google Scholar]
  130. Vannier C., Ailhaud G. A continuous flow method for the study of lipoprotein lipase secretion in adipose cells. Biochim Biophys Acta. 1986 Feb 12;875(2):324–333. doi: 10.1016/0005-2760(86)90183-9. [DOI] [PubMed] [Google Scholar]
  131. Vannier C., Ailhaud G. Biosynthesis of lipoprotein lipase in cultured mouse adipocytes. II. Processing, subunit assembly, and intracellular transport. J Biol Chem. 1989 Aug 5;264(22):13206–13216. [PubMed] [Google Scholar]
  132. Vannier C., Amri E. Z., Etienne J., Négrel R., Ailhaud G. Maturation and secretion of lipoprotein lipase in cultured adipose cells. I. Intracellular activation of the enzyme. J Biol Chem. 1985 Apr 10;260(7):4424–4431. [PubMed] [Google Scholar]
  133. Vannier C., Deslex S., Pradines-Figuères A., Ailhaud G. Biosynthesis of lipoprotein lipase in cultured mouse adipocytes. I. Characterization of a specific antibody and relationships between the intracellular and secreted pools of the enzyme. J Biol Chem. 1989 Aug 5;264(22):13199–13205. [PubMed] [Google Scholar]
  134. Vannier C., Etienne J., Ailhaud G. Intracellular localization of lipoprotein lipase in adipose cells. Biochim Biophys Acta. 1986 Feb 12;875(2):344–354. doi: 10.1016/0005-2760(86)90185-2. [DOI] [PubMed] [Google Scholar]
  135. Vilaró S., Llobera M., Bengtsson-Olivecrona G., Olivecrona T. Synthesis of lipoprotein lipase in the liver of newborn rats and localization of the enzyme by immunofluorescence. Biochem J. 1988 Jan 15;249(2):549–556. doi: 10.1042/bj2490549. [DOI] [PMC free article] [PubMed] [Google Scholar]
  136. Wang C. S., Hartsuck J., McConathy W. J. Structure and functional properties of lipoprotein lipase. Biochim Biophys Acta. 1992 Jan 3;1123(1):1–17. doi: 10.1016/0005-2760(92)90165-r. [DOI] [PubMed] [Google Scholar]
  137. Wion K. L., Kirchgessner T. G., Lusis A. J., Schotz M. C., Lawn R. M. Human lipoprotein lipase complementary DNA sequence. Science. 1987 Mar 27;235(4796):1638–1641. doi: 10.1126/science.3823907. [DOI] [PubMed] [Google Scholar]
  138. Wong H., Davis R. C., Nikazy J., Seebart K. E., Schotz M. C. Domain exchange: characterization of a chimeric lipase of hepatic lipase and lipoprotein lipase. Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11290–11294. doi: 10.1073/pnas.88.24.11290. [DOI] [PMC free article] [PubMed] [Google Scholar]
  139. Yang C. Y., Gu Z. W., Yang H. X., Rohde M. F., Gotto A. M., Jr, Pownall H. J. Structure of bovine milk lipoprotein lipase. J Biol Chem. 1989 Oct 5;264(28):16822–16827. [PubMed] [Google Scholar]
  140. Ylä-Herttuala S., Lipton B. A., Rosenfeld M. E., Goldberg I. J., Steinberg D., Witztum J. L. Macrophages and smooth muscle cells express lipoprotein lipase in human and rabbit atherosclerotic lesions. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10143–10147. doi: 10.1073/pnas.88.22.10143. [DOI] [PMC free article] [PubMed] [Google Scholar]

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