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. 1989 Sep 15;262(3):977–979. doi: 10.1042/bj2620977

4-Hydroxynonenal induces a DNA-binding protein similar to the heat-shock factor.

F Cajone 1, M Salina 1, A Benelli-Zazzera 1
PMCID: PMC1133369  PMID: 2590181

Abstract

By using a gel mobility assay, we have shown that treatment of HeLa cells with 4-hydroxynonenal, a major product of the peroxidation of membrane lipids and an inducer of heat-shock proteins, has the same effect as heat shock in causing the appearance of a protein which binds to the sequence of DNA specific for the induction of heat-shock genes. Lipoperoxidation and heat exposure seem to share a common mechanism of specific gene activation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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