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. 1989 Oct 1;263(1):289–292. doi: 10.1042/bj2630289

A simplified method for calculating complex metabolic sensitivities by using matrix partitioning.

B Crabtree 1, G Collins 1, M I Franklin 1
PMCID: PMC1133422  PMID: 2604700

Abstract

The matrix method for calculating the overall sensitivities (including control coefficients) of a metabolic system, described by Crabtree & Newsholme [Biochem. J. 247, 113-129 (1987)], is simplified by a preliminary partitioning of the initial matrix equation. This reduces the size of the matrix to be inverted and thereby removes a major drawback with the original method. The resulting procedure is simpler and more systematic than the alternative methods currently available, especially when the system is extensively branched.

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Selected References

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