Skip to main content
PMC home page
Biochemical Journal logoLink to Biochemical Journal
. 1993 Jun 15;292(Pt 3):787–789. doi: 10.1042/bj2920787

Procolipase mRNA: tissue localization and effects of diet and adrenalectomy.

S Okada 1, D A York 1, G A Bray 1
PMCID: PMC1134182  PMID: 8318008

Abstract

Northern blot analysis has identified procolipase mRNA in rat pancreas, stomach and duodenum. Pancreatic colipase mRNA was increased by high-fat diets. Adrenalectomy increased pancreatic procolipase mRNA, an effect enhanced by high-fat diets. The results suggest that colipase is not unique to the pancreas and that diet and glucocorticoids interact in regulating the transcription of its gene.

Full text

PDF
787

Images in this article

788Figure 1
on p.788
788Figure 2
on p.788
788Figure 3
on p.788

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bonicel J., Couchoud P., Foglizzo E., Desnuelle P., Chapus C. Amino acid sequence of horse colipase B. Biochim Biophys Acta. 1981 Jun 29;669(1):39–45. doi: 10.1016/0005-2795(81)90221-x. [DOI] [PubMed] [Google Scholar]
  2. Brindley D. N., Cooling J., Glenny H. P., Burditt S. L., McKechnie I. S. Effects of chronic modification of dietary fat and carbohydrate on the insulin, corticosterone and metabolic responses of rats fed acutely with glucose, fructose or ethanol. Biochem J. 1981 Nov 15;200(2):275–283. doi: 10.1042/bj2000275. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Charles M., Erlanson C., Bianchetta J., Joffre J., Guidoni A., Rovery M. The primary structure of porcine colipase II. I. The amino acid sequence. Biochim Biophys Acta. 1974 Jul 7;359(1):186–197. doi: 10.1016/0005-2795(74)90142-1. [DOI] [PubMed] [Google Scholar]
  4. Chirgwin J. M., Przybyla A. E., MacDonald R. J., Rutter W. J. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 1979 Nov 27;18(24):5294–5299. doi: 10.1021/bi00591a005. [DOI] [PubMed] [Google Scholar]
  5. Cleveland D. W., Lopata M. A., MacDonald R. J., Cowan N. J., Rutter W. J., Kirschner M. W. Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell. 1980 May;20(1):95–105. doi: 10.1016/0092-8674(80)90238-x. [DOI] [PubMed] [Google Scholar]
  6. Duan R. D., Erlanson-Albertsson C. Altered synthesis of some secretory proteins in pancreatic lobules isolated from streptozotocin-induced diabetic rats. Pancreas. 1990 Mar;5(2):136–143. doi: 10.1097/00006676-199003000-00003. [DOI] [PubMed] [Google Scholar]
  7. Duan R. D., Erlanson-Albertsson C. Pancreatic lipase and colipase activity increase in pancreatic acinar tissue of diabetic rats. Pancreas. 1989;4(3):329–334. doi: 10.1097/00006676-198906000-00009. [DOI] [PubMed] [Google Scholar]
  8. Erlanson-Albertsson C., Larsson A. A possible physiological function of pancreatic pro-colipase activation peptide in appetite regulation. Biochimie. 1988 Sep;70(9):1245–1250. doi: 10.1016/0300-9084(88)90191-5. [DOI] [PubMed] [Google Scholar]
  9. Erlanson-Albertsson C., Mei J., Okada S., York D., Bray G. A. Pancreatic procolipase propeptide, enterostatin, specifically inhibits fat intake. Physiol Behav. 1991 Jun;49(6):1191–1194. doi: 10.1016/0031-9384(91)90350-w. [DOI] [PubMed] [Google Scholar]
  10. Holt S., York D. A. The effect of adrenalectomy on GDP binding to brown-adipose-tissue mitochondria of obese rat. Biochem J. 1982 Dec 15;208(3):819–822. doi: 10.1042/bj2080819. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Lowe M. E., Rosenblum J. L., McEwen P., Strauss A. W. Cloning and characterization of the human colipase cDNA. Biochemistry. 1990 Jan 23;29(3):823–828. doi: 10.1021/bi00455a032. [DOI] [PubMed] [Google Scholar]
  12. Murphy R. B., Smith G. P., Gibbs J. Pharmacological examination of cholecystokinin (CCK-8)-induced contractile activity in the rat isolated pylorus. Peptides. 1987 Jan-Feb;8(1):127–134. doi: 10.1016/0196-9781(87)90176-8. [DOI] [PubMed] [Google Scholar]
  13. Okada S., York D. A., Bray G. A., Erlanson-Albertsson C. Enterostatin (Val-Pro-Asp-Pro-Arg), the activation peptide of procolipase, selectively reduces fat intake. Physiol Behav. 1991 Jun;49(6):1185–1189. doi: 10.1016/0031-9384(91)90349-s. [DOI] [PubMed] [Google Scholar]
  14. Okada S., York D. A., Bray G. A., Mei J., Erlanson-Albertsson C. Differential inhibition of fat intake in two strains of rat by the peptide enterostatin. Am J Physiol. 1992 Jun;262(6 Pt 2):R1111–R1116. doi: 10.1152/ajpregu.1992.262.6.R1111. [DOI] [PubMed] [Google Scholar]
  15. Okada S., York D. A., Bray G. A. Mifepristone (RU 486), a blocker of type II glucocorticoid and progestin receptors, reverses a dietary form of obesity. Am J Physiol. 1992 Jun;262(6 Pt 2):R1106–R1110. doi: 10.1152/ajpregu.1992.262.6.R1106. [DOI] [PubMed] [Google Scholar]
  16. Shargill N. S., Tsujii S., Bray G. A., Erlanson-Albertsson C. Enterostatin suppresses food intake following injection into the third ventricle of rats. Brain Res. 1991 Mar 22;544(1):137–140. doi: 10.1016/0006-8993(91)90895-3. [DOI] [PubMed] [Google Scholar]
  17. Sternby B., Engström A., Hellman U., Vihert A. M., Sternby N. H., Borgström B. The primary sequence of human pancreatic colipase. Biochim Biophys Acta. 1984 Jan 18;784(1):75–80. doi: 10.1016/0167-4838(84)90175-4. [DOI] [PubMed] [Google Scholar]
  18. Wicker C., Puigserver A. Changes in mRNA levels of rat pancreatic lipase in the early days of consumption of a high-lipid diet. Eur J Biochem. 1989 Apr 1;180(3):563–567. doi: 10.1111/j.1432-1033.1989.tb14682.x. [DOI] [PubMed] [Google Scholar]
  19. Wicker C., Puigserver A. Rat pancreatic colipase mRNA: nucleotide sequence of a cDNA clone and nutritional regulation by a lipidic diet. Biochem Biophys Res Commun. 1990 Feb 28;167(1):130–136. doi: 10.1016/0006-291x(90)91740-j. [DOI] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES