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. 1993 Jul 1;293(Pt 1):1–13. doi: 10.1042/bj2930001

Mammalian glucokinase and its gene.

P B Iynedjian 1
PMCID: PMC1134312  PMID: 8392329

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  1. Agius L., Peak M., Alberti K. G. Regulation of glycogen synthesis from glucose and gluconeogenic precursors by insulin in periportal and perivenous rat hepatocytes. Biochem J. 1990 Feb 15;266(1):91–102. doi: 10.1042/bj2660091. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Andreone T. L., Printz R. L., Pilkis S. J., Magnuson M. A., Granner D. K. The amino acid sequence of rat liver glucokinase deduced from cloned cDNA. J Biol Chem. 1989 Jan 5;264(1):363–369. [PubMed] [Google Scholar]
  3. Ashcroft F. M., Harrison D. E., Ashcroft S. J. Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells. 1984 Nov 29-Dec 5Nature. 312(5993):446–448. doi: 10.1038/312446a0. [DOI] [PubMed] [Google Scholar]
  4. Ashcroft F. M., Rorsman P. Electrophysiology of the pancreatic beta-cell. Prog Biophys Mol Biol. 1989;54(2):87–143. doi: 10.1016/0079-6107(89)90013-8. [DOI] [PubMed] [Google Scholar]
  5. Ashcroft S. J. Glucoreceptor mechanisms and the control of insulin release and biosynthesis. Diabetologia. 1980 Jan;18(1):5–15. doi: 10.1007/BF01228295. [DOI] [PubMed] [Google Scholar]
  6. Ashcroft S. J., Randle P. J. Enzymes of glucose metabolism in normal mouse pancreatic islets. Biochem J. 1970 Aug;119(1):5–15. doi: 10.1042/bj1190005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bartels H., Vogt B., Jungermann K. Glycogen synthesis from pyruvate in the periportal and from glucose in the perivenous zone in perfused livers from fasted rats. FEBS Lett. 1987 Sep 14;221(2):277–283. doi: 10.1016/0014-5793(87)80940-7. [DOI] [PubMed] [Google Scholar]
  8. Bedoya F. J., Meglasson M. D., Wilson J. M., Matschinsky F. M. Radiometric oil well assay for glucokinase in microscopic structures. Anal Biochem. 1985 Feb 1;144(2):504–513. doi: 10.1016/0003-2697(85)90147-2. [DOI] [PubMed] [Google Scholar]
  9. Bennett W. S., Jr, Steitz T. A. Structure of a complex between yeast hexokinase A and glucose. II. Detailed comparisons of conformation and active site configuration with the native hexokinase B monomer and dimer. J Mol Biol. 1980 Jun 25;140(2):211–230. doi: 10.1016/0022-2836(80)90103-5. [DOI] [PubMed] [Google Scholar]
  10. Blackshear P. J., Haupt D. M., Stumpo D. J. Insulin activation of protein kinase C: a reassessment. J Biol Chem. 1991 Jun 15;266(17):10946–10952. [PubMed] [Google Scholar]
  11. Boam D. S., Docherty K. A tissue-specific nuclear factor binds to multiple sites in the human insulin-gene enhancer. Biochem J. 1989 Nov 15;264(1):233–239. doi: 10.1042/bj2640233. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Bork P., Sander C., Valencia A. An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7290–7294. doi: 10.1073/pnas.89.16.7290. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. CAHILL G. F., Jr, ASHMORE J., EARLE A. S., ZOTTU S. Glucose penetration into liver. Am J Physiol. 1958 Mar;192(3):491–496. doi: 10.1152/ajplegacy.1958.192.3.491. [DOI] [PubMed] [Google Scholar]
  14. CAHILL G. F., Jr, ASHMORE J., RENOLD A. E., HASTINGS A. B. Blood glucose and the liver. Am J Med. 1959 Feb;26(2):264–282. doi: 10.1016/0002-9343(59)90316-x. [DOI] [PubMed] [Google Scholar]
  15. Capecchi M. R. Altering the genome by homologous recombination. Science. 1989 Jun 16;244(4910):1288–1292. doi: 10.1126/science.2660260. [DOI] [PubMed] [Google Scholar]
  16. Chauhan J., Dakshinamurti K. Transcriptional regulation of the glucokinase gene by biotin in starved rats. J Biol Chem. 1991 Jun 5;266(16):10035–10038. [PubMed] [Google Scholar]
  17. Cherry J. R., Johnson T. R., Dollard C., Shuster J. R., Denis C. L. Cyclic AMP-dependent protein kinase phosphorylates and inactivates the yeast transcriptional activator ADR1. Cell. 1989 Feb 10;56(3):409–419. doi: 10.1016/0092-8674(89)90244-4. [DOI] [PubMed] [Google Scholar]
  18. Ciaraldi T. P., Horuk R., Matthaei S. Biochemical and functional characterization of the rat liver glucose-transport system. Comparisons with the adipocyte glucose-transport system. Biochem J. 1986 Nov 15;240(1):115–123. doi: 10.1042/bj2400115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Clarke S. D., Abraham S. Gene expression: nutrient control of pre- and posttranscriptional events. FASEB J. 1992 Oct;6(13):3146–3152. doi: 10.1096/fasebj.6.13.1397836. [DOI] [PubMed] [Google Scholar]
  20. Connolly B. A., Trayer I. P. Reaction of rat hepatic glucokinase with substrate-related and other alkylating agents. Eur J Biochem. 1979 Sep;99(2):299–308. doi: 10.1111/j.1432-1033.1979.tb13257.x. [DOI] [PubMed] [Google Scholar]
  21. Cook D. L., Hales C. N. Intracellular ATP directly blocks K+ channels in pancreatic B-cells. Nature. 1984 Sep 20;311(5983):271–273. doi: 10.1038/311271a0. [DOI] [PubMed] [Google Scholar]
  22. Cook J. T., Hattersley A. T., Christopher P., Bown E., Barrow B., Patel P., Shaw J. A., Cookson W. O., Permutt M. A., Turner R. C. Linkage analysis of glucokinase gene with NIDDM in Caucasian pedigrees. Diabetes. 1992 Nov;41(11):1496–1500. doi: 10.2337/diab.41.11.1496. [DOI] [PubMed] [Google Scholar]
  23. Cornish-Bowden A., Storer A. C. Mechanistic origin of the sigmoidal rate behaviour of rat liver hexokinase D ('glucokinase'). Biochem J. 1986 Nov 15;240(1):293–296. doi: 10.1042/bj2400293. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Cox N. J., Xiang K. S., Fajans S. S., Bell G. I. Mapping diabetes-susceptibility genes. Lessons learned from search for DNA marker for maturity-onset diabetes of the young. Diabetes. 1992 Apr;41(4):401–407. doi: 10.2337/diab.41.4.401. [DOI] [PubMed] [Google Scholar]
  25. Cárdenas M. L., Rabajille E., Niemeyer H. Suppression of kinetic cooperativity of hexokinase D (glucokinase) by competitive inhibitors. A slow transition model. Eur J Biochem. 1984 Nov 15;145(1):163–171. doi: 10.1111/j.1432-1033.1984.tb08536.x. [DOI] [PubMed] [Google Scholar]
  26. DIPIETRO D. L., SHARMA C., WEINHOUSE S. Studies on glucose phosphorylation in rat liver. Biochemistry. 1962 May 25;1:455–462. doi: 10.1021/bi00909a014. [DOI] [PubMed] [Google Scholar]
  27. DIPIETRO D. L., WEINHOUSE S. Hepatic glucokinase in the fed, fasted, and alloxan-diabetic rat. J Biol Chem. 1960 Sep;235:2542–2545. [PubMed] [Google Scholar]
  28. Davidson A. L., Arion W. J. Factors underlying significant underestimations of glucokinase activity in crude liver extracts: physiological implications of higher cellular activity. Arch Biochem Biophys. 1987 Feb 15;253(1):156–167. doi: 10.1016/0003-9861(87)90648-5. [DOI] [PubMed] [Google Scholar]
  29. Davies D. R., Detheux M., Van Schaftingen E. Fructose 1-phosphate and the regulation of glucokinase activity in isolated hepatocytes. Eur J Biochem. 1990 Sep 11;192(2):283–289. doi: 10.1111/j.1432-1033.1990.tb19225.x. [DOI] [PubMed] [Google Scholar]
  30. Dawson C. M., Hales C. N. The inhibition of rat liver glucokinase by palmitoyl-CoA. Biochim Biophys Acta. 1969 Apr 29;176(3):657–659. doi: 10.1016/0005-2760(69)90238-0. [DOI] [PubMed] [Google Scholar]
  31. Decaux J. F., Antoine B., Kahn A. Regulation of the expression of the L-type pyruvate kinase gene in adult rat hepatocytes in primary culture. J Biol Chem. 1989 Jul 15;264(20):11584–11590. [PubMed] [Google Scholar]
  32. Dent P., Lavoinne A., Nakielny S., Caudwell F. B., Watt P., Cohen P. The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle. Nature. 1990 Nov 22;348(6299):302–308. doi: 10.1038/348302a0. [DOI] [PubMed] [Google Scholar]
  33. Edwards D. R., Mahadevan L. C. Protein synthesis inhibitors differentially superinduce c-fos and c-jun by three distinct mechanisms: lack of evidence for labile repressors. EMBO J. 1992 Jul;11(7):2415–2424. doi: 10.1002/j.1460-2075.1992.tb05306.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Ekman P., Nilsson E. Phosphorylation of glucokinase from rat liver in vitro by protein kinase A with a concomitant decrease of its activity. Arch Biochem Biophys. 1988 Mar;261(2):275–282. doi: 10.1016/0003-9861(88)90342-6. [DOI] [PubMed] [Google Scholar]
  35. Fajans S. S. Scope and heterogeneous nature of MODY. Diabetes Care. 1990 Jan;13(1):49–64. doi: 10.2337/diacare.13.1.49. [DOI] [PubMed] [Google Scholar]
  36. Fernandez-Mejia C., Davidson M. B. Regulation of glucokinase and proinsulin gene expression and insulin secretion in RIN-m5F cells by dexamethasone, retinoic acid, and thyroid hormone. Endocrinology. 1992 Mar;130(3):1660–1668. doi: 10.1210/endo.130.3.1537314. [DOI] [PubMed] [Google Scholar]
  37. Flawn P., Loten E. G. Properties and distribution of cyclic AMP phosphodiesterase from rat liver. Int J Biochem. 1990;22(9):983–988. doi: 10.1016/0020-711x(90)90204-g. [DOI] [PubMed] [Google Scholar]
  38. Froguel P., Vaxillaire M., Sun F., Velho G., Zouali H., Butel M. O., Lesage S., Vionnet N., Clément K., Fougerousse F. Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus. Nature. 1992 Mar 12;356(6365):162–164. doi: 10.1038/356162a0. [DOI] [PubMed] [Google Scholar]
  39. Froguel P., Zouali H., Vionnet N., Velho G., Vaxillaire M., Sun F., Lesage S., Stoffel M., Takeda J., Passa P. Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus. N Engl J Med. 1993 Mar 11;328(10):697–702. doi: 10.1056/NEJM199303113281005. [DOI] [PubMed] [Google Scholar]
  40. Gidh-Jain M., Takeda J., Xu L. Z., Lange A. J., Vionnet N., Stoffel M., Froguel P., Velho G., Sun F., Cohen D. Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships. Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1932–1936. doi: 10.1073/pnas.90.5.1932. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Giroix M. H., Sener A., Pipeleers D. G., Malaisse W. J. Hexose metabolism in pancreatic islets. Inhibition of hexokinase. Biochem J. 1984 Oct 15;223(2):447–453. doi: 10.1042/bj2230447. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Gorus F. K., Malaisse W. J., Pipeleers D. G. Differences in glucose handling by pancreatic A- and B-cells. J Biol Chem. 1984 Jan 25;259(2):1196–1200. [PubMed] [Google Scholar]
  43. Grossbard L., Schimke R. T. Multiple hexokinases of rat tissues. Purification and comparison of soluble forms. J Biol Chem. 1966 Aug 10;241(15):3546–3560. [PubMed] [Google Scholar]
  44. Hattersley A. T., Turner R. C., Permutt M. A., Patel P., Tanizawa Y., Chiu K. C., O'Rahilly S., Watkins P. J., Wainscoat J. S. Linkage of type 2 diabetes to the glucokinase gene. Lancet. 1992 May 30;339(8805):1307–1310. doi: 10.1016/0140-6736(92)91958-b. [DOI] [PubMed] [Google Scholar]
  45. Hayzer D. J., Iynedjian P. B. Alternative splicing of glucokinase mRNA in rat liver. Biochem J. 1990 Aug 15;270(1):261–263. doi: 10.1042/bj2700261. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Hellman B., Sehlin J., Täljedal I. B. Evidence for mediated transport of glucose in mammalian pancreatic -cells. Biochim Biophys Acta. 1971 Jul 6;241(1):147–154. doi: 10.1016/0005-2736(71)90312-9. [DOI] [PubMed] [Google Scholar]
  47. Holmes K. C., Sander C., Valencia A. A new ATP-binding fold in actin, hexokinase and Hsc70. Trends Cell Biol. 1993 Feb;3(2):53–59. doi: 10.1016/0962-8924(93)90161-s. [DOI] [PubMed] [Google Scholar]
  48. Holroyde M. J., Allen M. B., Storer A. C., Warsy A. S., Chesher J. M., Trayer I. P., Cornish-Bowden A., Walker D. G. The purification in high yield and characterization of rat hepatic glucokinase. Biochem J. 1976 Feb 1;153(2):363–373. doi: 10.1042/bj1530363. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Huang M. T., Veech R. L. Role of the direct and indirect pathways for glycogen synthesis in rat liver in the postprandial state. J Clin Invest. 1988 Mar;81(3):872–878. doi: 10.1172/JCI113397. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Hue L. The role of futile cycles in the regulation of carbohydrate metabolism in the liver. Adv Enzymol Relat Areas Mol Biol. 1981;52:247–331. doi: 10.1002/9780470122976.ch4. [DOI] [PubMed] [Google Scholar]
  51. Hughes S. D., Quaade C., Milburn J. L., Cassidy L., Newgard C. B. Expression of normal and novel glucokinase mRNAs in anterior pituitary and islet cells. J Biol Chem. 1991 Mar 5;266(7):4521–4530. [PubMed] [Google Scholar]
  52. Hunter T., Karin M. The regulation of transcription by phosphorylation. Cell. 1992 Aug 7;70(3):375–387. doi: 10.1016/0092-8674(92)90162-6. [DOI] [PubMed] [Google Scholar]
  53. Höppner W., Seitz H. J. Effect of thyroid hormones on glucokinase gene transcription in rat liver. J Biol Chem. 1989 Dec 5;264(34):20643–20647. [PubMed] [Google Scholar]
  54. Iynedjian P. B., Gjinovci A., Renold A. E. Stimulation by insulin of glucokinase gene transcription in liver of diabetic rats. J Biol Chem. 1988 Jan 15;263(2):740–744. [PubMed] [Google Scholar]
  55. Iynedjian P. B., Jotterand D., Nouspikel T., Asfari M., Pilot P. R. Transcriptional induction of glucokinase gene by insulin in cultured liver cells and its repression by the glucagon-cAMP system. J Biol Chem. 1989 Dec 25;264(36):21824–21829. [PubMed] [Google Scholar]
  56. Iynedjian P. B., Möbius G., Seitz H. J., Wollheim C. B., Renold A. E. Tissue-specific expression of glucokinase: identification of the gene product in liver and pancreatic islets. Proc Natl Acad Sci U S A. 1986 Apr;83(7):1998–2001. doi: 10.1073/pnas.83.7.1998. [DOI] [PMC free article] [PubMed] [Google Scholar]
  57. Iynedjian P. B., Pilot P. R., Nouspikel T., Milburn J. L., Quaade C., Hughes S., Ucla C., Newgard C. B. Differential expression and regulation of the glucokinase gene in liver and islets of Langerhans. Proc Natl Acad Sci U S A. 1989 Oct;86(20):7838–7842. doi: 10.1073/pnas.86.20.7838. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. Iynedjian P. B., Ucla C., Mach B. Molecular cloning of glucokinase cDNA. Developmental and dietary regulation of glucokinase mRNA in rat liver. J Biol Chem. 1987 May 5;262(13):6032–6038. [PubMed] [Google Scholar]
  59. Jacoby D. B., Zilz N. D., Towle H. C. Sequences within the 5'-flanking region of the S14 gene confer responsiveness to glucose in primary hepatocytes. J Biol Chem. 1989 Oct 25;264(30):17623–17626. [PubMed] [Google Scholar]
  60. Jarnagin W. R., Debs R. J., Wang S. S., Bissell D. M. Cationic lipid-mediated transfection of liver cells in primary culture. Nucleic Acids Res. 1992 Aug 25;20(16):4205–4211. doi: 10.1093/nar/20.16.4205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  61. Johnson J. H., Newgard C. B., Milburn J. L., Lodish H. F., Thorens B. The high Km glucose transporter of islets of Langerhans is functionally similar to the low affinity transporter of liver and has an identical primary sequence. J Biol Chem. 1990 Apr 25;265(12):6548–6551. [PubMed] [Google Scholar]
  62. Jungermann K., Katz N. Functional specialization of different hepatocyte populations. Physiol Rev. 1989 Jul;69(3):708–764. doi: 10.1152/physrev.1989.69.3.708. [DOI] [PubMed] [Google Scholar]
  63. Katagiri H., Asano T., Ishihara H., Inukai K., Anai M., Miyazaki J., Tsukuda K., Kikuchi M., Yazaki Y., Oka Y. Nonsense mutation of glucokinase gene in late-onset non-insulin-dependent diabetes mellitus. Lancet. 1992 Nov 28;340(8831):1316–1317. doi: 10.1016/0140-6736(92)92494-z. [DOI] [PubMed] [Google Scholar]
  64. Katz N., Teutsch H. F., Jungermann K., Sasse D. Heterogeneous reciprocal localization of fructose-1,6-bisphosphatase and of glucokinase in microdissected periportal and perivenous rat liver tissue. FEBS Lett. 1977 Nov 15;83(2):272–276. doi: 10.1016/0014-5793(77)81021-1. [DOI] [PubMed] [Google Scholar]
  65. Katz N., Teutsch H. F., Sasse D., Jungermann K. Heterogeneous distribution of glucose-6-phosphatase in microdissected periportal and perivenous rat liver tissue. FEBS Lett. 1977 Apr 15;76(2):226–230. doi: 10.1016/0014-5793(77)80157-9. [DOI] [PubMed] [Google Scholar]
  66. Kemp B. E., Pearson R. B. Protein kinase recognition sequence motifs. Trends Biochem Sci. 1990 Sep;15(9):342–346. doi: 10.1016/0968-0004(90)90073-k. [DOI] [PubMed] [Google Scholar]
  67. Khan A., Chandramouli V., Ostenson C. G., Ahrén B., Schumann W. C., Löw H., Landau B. R., Efendić S. Evidence for the presence of glucose cycling in pancreatic islets of the ob/ob mouse. J Biol Chem. 1989 Jun 15;264(17):9732–9733. [PubMed] [Google Scholar]
  68. Khan A., Chandramouli V., Ostenson C. G., Löw H., Landau B. R., Efendić S. Glucose cycling in islets from healthy and diabetic rats. Diabetes. 1990 Apr;39(4):456–459. doi: 10.2337/diab.39.4.456. [DOI] [PubMed] [Google Scholar]
  69. Koranyi L. I., Bourey R. E., Slentz C. A., Holloszy J. O., Permutt M. A. Coordinate reduction of rat pancreatic islet glucokinase and proinsulin mRNA by exercise training. Diabetes. 1991 Mar;40(3):401–404. doi: 10.2337/diab.40.3.401. [DOI] [PubMed] [Google Scholar]
  70. Kyriakis J. M., App H., Zhang X. F., Banerjee P., Brautigan D. L., Rapp U. R., Avruch J. Raf-1 activates MAP kinase-kinase. Nature. 1992 Jul 30;358(6385):417–421. doi: 10.1038/358417a0. [DOI] [PubMed] [Google Scholar]
  71. Lange A. J., Xu L. Z., Van Poelwijk F., Lin K., Granner D. K., Pilkis S. J. Expression and site-directed mutagenesis of hepatic glucokinase. Biochem J. 1991 Jul 1;277(Pt 1):159–163. doi: 10.1042/bj2770159. [DOI] [PMC free article] [PubMed] [Google Scholar]
  72. Lavoinne A., Erikson E., Maller J. L., Price D. J., Avruch J., Cohen P. Purification and characterisation of the insulin-stimulated protein kinase from rabbit skeletal muscle; close similarity to S6 kinase II. Eur J Biochem. 1991 Aug 1;199(3):723–728. doi: 10.1111/j.1432-1033.1991.tb16176.x. [DOI] [PubMed] [Google Scholar]
  73. Lawrence G. M., Trayer I. P., Walker D. G. Histochemical and immunohistochemical localization of hexokinase isoenzymes in normal rat liver. Histochem J. 1984 Oct;16(10):1099–1111. doi: 10.1007/BF01002897. [DOI] [PubMed] [Google Scholar]
  74. Liang Y., Jetton T. L., Zimmerman E. C., Najafi H., Matschinsky F. M., Magnuson M. A. Effects of alternate RNA splicing on glucokinase isoform activities in the pancreatic islet, liver, and pituitary. J Biol Chem. 1991 Apr 15;266(11):6999–7007. [PubMed] [Google Scholar]
  75. Liang Y., Najafi H., Matschinsky F. M. Glucose regulates glucokinase activity in cultured islets from rat pancreas. J Biol Chem. 1990 Oct 5;265(28):16863–16866. [PubMed] [Google Scholar]
  76. Liang Y., Najafi H., Smith R. M., Zimmerman E. C., Magnuson M. A., Tal M., Matschinsky F. M. Concordant glucose induction of glucokinase, glucose usage, and glucose-stimulated insulin release in pancreatic islets maintained in organ culture. Diabetes. 1992 Jul;41(7):792–806. doi: 10.2337/diab.41.7.792. [DOI] [PubMed] [Google Scholar]
  77. Lin S. X., Neet K. E. Demonstration of a slow conformational change in liver glucokinase by fluorescence spectroscopy. J Biol Chem. 1990 Jun 15;265(17):9670–9675. [PubMed] [Google Scholar]
  78. Magnani M., Bianchi M., Casabianca A., Stocchi V., Daniele A., Altruda F., Ferrone M., Silengo L. A recombinant human 'mini'-hexokinase is catalytically active and regulated by hexose 6-phosphates. Biochem J. 1992 Jul 1;285(Pt 1):193–199. doi: 10.1042/bj2850193. [DOI] [PMC free article] [PubMed] [Google Scholar]
  79. Magnuson M. A., Andreone T. L., Printz R. L., Koch S., Granner D. K. Rat glucokinase gene: structure and regulation by insulin. Proc Natl Acad Sci U S A. 1989 Jul;86(13):4838–4842. doi: 10.1073/pnas.86.13.4838. [DOI] [PMC free article] [PubMed] [Google Scholar]
  80. Magnuson M. A. Glucokinase gene structure. Functional implications of molecular genetic studies. Diabetes. 1990 May;39(5):523–527. doi: 10.2337/diab.39.5.523. [DOI] [PubMed] [Google Scholar]
  81. Magnuson M. A., Shelton K. D. An alternate promoter in the glucokinase gene is active in the pancreatic beta cell. J Biol Chem. 1989 Sep 25;264(27):15936–15942. [PubMed] [Google Scholar]
  82. Magnuson M. A. Tissue-specific regulation of glucokinase gene expression. J Cell Biochem. 1992 Feb;48(2):115–121. doi: 10.1002/jcb.240480202. [DOI] [PubMed] [Google Scholar]
  83. Mahadevan L. C., Willis A. C., Barratt M. J. Rapid histone H3 phosphorylation in response to growth factors, phorbol esters, okadaic acid, and protein synthesis inhibitors. Cell. 1991 May 31;65(5):775–783. doi: 10.1016/0092-8674(91)90385-c. [DOI] [PubMed] [Google Scholar]
  84. Malaisse W. J., Malaisse-Lagae F., Davies D. R., Vandercammen A., Van Schaftingen E. Regulation of glucokinase by a fructose-1-phosphate-sensitive protein in pancreatic islets. Eur J Biochem. 1990 Jul 5;190(3):539–545. doi: 10.1111/j.1432-1033.1990.tb15607.x. [DOI] [PubMed] [Google Scholar]
  85. Martin B. C., Warram J. H., Krolewski A. S., Bergman R. N., Soeldner J. S., Kahn C. R. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet. 1992 Oct 17;340(8825):925–929. doi: 10.1016/0140-6736(92)92814-v. [DOI] [PubMed] [Google Scholar]
  86. Matschinsky F. M., Ellerman J. E. Metabolism of glucose in the islets of Langerhans. J Biol Chem. 1968 May 25;243(10):2730–2736. [PubMed] [Google Scholar]
  87. Matsuda T., Noguchi T., Yamada K., Takenaka M., Tanaka T. Regulation of the gene expression of glucokinase and L-type pyruvate kinase in primary cultures of rat hepatocytes by hormones and carbohydrates. J Biochem. 1990 Nov;108(5):778–784. doi: 10.1093/oxfordjournals.jbchem.a123280. [DOI] [PubMed] [Google Scholar]
  88. Meglasson M. D., Matschinsky F. M. New perspectives on pancreatic islet glucokinase. Am J Physiol. 1984 Jan;246(1 Pt 1):E1–13. doi: 10.1152/ajpendo.1984.246.1.E1. [DOI] [PubMed] [Google Scholar]
  89. Meglasson M. D., Matschinsky F. M. Pancreatic islet glucose metabolism and regulation of insulin secretion. Diabetes Metab Rev. 1986;2(3-4):163–214. doi: 10.1002/dmr.5610020301. [DOI] [PubMed] [Google Scholar]
  90. Middleton R. J. Hexokinases and glucokinases. Biochem Soc Trans. 1990 Apr;18(2):180–183. doi: 10.1042/bst0180180. [DOI] [PubMed] [Google Scholar]
  91. Minderop R. H., Hoeppner W., Seitz H. J. Regulation of hepatic glucokinase gene expression. Role of carbohydrates, and glucocorticoid and thyroid hormones. Eur J Biochem. 1987 Apr 1;164(1):181–187. doi: 10.1111/j.1432-1033.1987.tb11009.x. [DOI] [PubMed] [Google Scholar]
  92. Moorman A. F., de Boer P. A., Charles R., Lamers W. H. Pericentral expression pattern of glucokinase mRNA in the rat liver lobulus. FEBS Lett. 1991 Aug 5;287(1-2):47–52. doi: 10.1016/0014-5793(91)80013-s. [DOI] [PubMed] [Google Scholar]
  93. Nakielny S., Cohen P., Wu J., Sturgill T. MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase. EMBO J. 1992 Jun;11(6):2123–2129. doi: 10.1002/j.1460-2075.1992.tb05271.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  94. Narkewicz M. R., Iynedjian P. B., Ferre P., Girard J. Insulin and tri-iodothyronine induce glucokinase mRNA in primary cultures of neonatal rat hepatocytes. Biochem J. 1990 Nov 1;271(3):585–589. doi: 10.1042/bj2710585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  95. Neet K. E., Ainslie G. R., Jr Hysteretic enzymes. Methods Enzymol. 1980;64:192–226. doi: 10.1016/s0076-6879(80)64010-5. [DOI] [PubMed] [Google Scholar]
  96. Neet K. E., Keenan R. P., Tippett P. S. Observation of a kinetic slow transition in monomeric glucokinase. Biochemistry. 1990 Jan 23;29(3):770–777. doi: 10.1021/bi00455a026. [DOI] [PubMed] [Google Scholar]
  97. Newgard C. B., Quaade C., Hughes S. D., Milburn J. L. Glucokinase and glucose transporter expression in liver and islets: implications for control of glucose homoeostasis. Biochem Soc Trans. 1990 Oct;18(5):851–853. doi: 10.1042/bst0180851. [DOI] [PubMed] [Google Scholar]
  98. Niemeyer H., Pérez N., Codoceo R. Liver glucokinase induction in acute and chronic insulin insufficiency in rats. J Biol Chem. 1967 Mar 10;242(5):860–864. [PubMed] [Google Scholar]
  99. Niemeyer H., de la Luz Cárdenas M., Rabajille E., Ureta T., Clark-Turri L., Peñaranda J. Sigmoidal kinetics of glucokinase. Enzyme. 1975;20(6):321–333. doi: 10.1159/000458957. [DOI] [PubMed] [Google Scholar]
  100. Nishi S., Seino S., Bell G. I. Human hexokinase: sequences of amino- and carboxyl-terminal halves are homologous. Biochem Biophys Res Commun. 1988 Dec 30;157(3):937–943. doi: 10.1016/s0006-291x(88)80964-1. [DOI] [PubMed] [Google Scholar]
  101. Noguchi T., Takenaka M., Yamada K., Matsuda T., Hashimoto M., Tanaka T. Characterization of the 5' flanking region of rat glucokinase gene. Biochem Biophys Res Commun. 1989 Nov 15;164(3):1247–1252. doi: 10.1016/0006-291x(89)91803-2. [DOI] [PubMed] [Google Scholar]
  102. Nouspikel T., Gjinovci A., Li S., Iynedjian P. B. Unimpaired effect of insulin on glucokinase gene expression in hepatocytes challenged with amylin. FEBS Lett. 1992 Apr 13;301(1):115–118. doi: 10.1016/0014-5793(92)80222-3. [DOI] [PubMed] [Google Scholar]
  103. Nouspikel T., Iynedjian P. B. Insulin signalling and regulation of glucokinase gene expression in cultured hepatocytes. Eur J Biochem. 1992 Nov 15;210(1):365–373. doi: 10.1111/j.1432-1033.1992.tb17430.x. [DOI] [PubMed] [Google Scholar]
  104. Ohlsson H., Thor S., Edlund T. Novel insulin promoter- and enhancer-binding proteins that discriminate between pancreatic alpha- and beta-cells. Mol Endocrinol. 1991 Jul;5(7):897–904. doi: 10.1210/mend-5-7-897. [DOI] [PubMed] [Google Scholar]
  105. Parry M. J., Walker D. G. Further properties and possibel mechanism of action of adenosine 5'-triphosphate-D-glucose 6-phosphotransferase from rat liver. Biochem J. 1967 Nov;105(2):473–482. doi: 10.1042/bj1050473. [DOI] [PMC free article] [PubMed] [Google Scholar]
  106. Parry M. J., Walker D. G. Purification and properties of adenosine 5'-triphospae-D-glucose 6-phosphotransferase from rat liver. Biochem J. 1966 May;99(2):266–274. doi: 10.1042/bj0990266. [DOI] [PMC free article] [PubMed] [Google Scholar]
  107. Permutt M. A., Chiu K. C., Tanizawa Y. Glucokinase and NIDDM. A candidate gene that paid off. Diabetes. 1992 Nov;41(11):1367–1372. doi: 10.2337/diab.41.11.1367. [DOI] [PubMed] [Google Scholar]
  108. Pessin J. E., Bell G. I. Mammalian facilitative glucose transporter family: structure and molecular regulation. Annu Rev Physiol. 1992;54:911–930. doi: 10.1146/annurev.ph.54.030192.004403. [DOI] [PubMed] [Google Scholar]
  109. Pilkis S. J. Glucokinase of rat liver. Methods Enzymol. 1975;42:31–39. doi: 10.1016/0076-6879(75)42088-2. [DOI] [PubMed] [Google Scholar]
  110. Pipeleers D. G. Heterogeneity in pancreatic beta-cell population. Diabetes. 1992 Jul;41(7):777–781. doi: 10.2337/diab.41.7.777. [DOI] [PubMed] [Google Scholar]
  111. Quaade C., Hughes S. D., Coats W. S., Sestak A. L., Iynedjian P. B., Newgard C. B. Analysis of the protein products encoded by variant glucokinase transcripts via expression in bacteria. FEBS Lett. 1991 Mar 11;280(1):47–52. doi: 10.1016/0014-5793(91)80201-d. [DOI] [PubMed] [Google Scholar]
  112. Rao M. S., Dwivedi R. S., Yeldandi A. V., Subbarao V., Tan X. D., Usman M. I., Thangada S., Nemali M. R., Kumar S., Scarpelli D. G. Role of periductal and ductular epithelial cells of the adult rat pancreas in pancreatic hepatocyte lineage. A change in the differentiation commitment. Am J Pathol. 1989 May;134(5):1069–1086. [PMC free article] [PubMed] [Google Scholar]
  113. Ricard J., Cornish-Bowden A. Co-operative and allosteric enzymes: 20 years on. Eur J Biochem. 1987 Jul 15;166(2):255–272. doi: 10.1111/j.1432-1033.1987.tb13510.x. [DOI] [PubMed] [Google Scholar]
  114. SHARMA C., MANJESHWAR R., WEINHOUSE S. EFFECTS OF DIET AND INSULIN ON GLUCOSE-ADENOSINE TRIPHOSPHATE PHOSPHOTRANSFERASES OF RAT LIVER. J Biol Chem. 1963 Dec;238:3840–3845. [PubMed] [Google Scholar]
  115. Satoh T., Nakafuku M., Kaziro Y. Function of Ras as a molecular switch in signal transduction. J Biol Chem. 1992 Dec 5;267(34):24149–24152. [PubMed] [Google Scholar]
  116. Schibler U., Sierra F. Alternative promoters in developmental gene expression. Annu Rev Genet. 1987;21:237–257. doi: 10.1146/annurev.ge.21.120187.001321. [DOI] [PubMed] [Google Scholar]
  117. Schwab D. A., Wilson J. E. Complete amino acid sequence of rat brain hexokinase, deduced from the cloned cDNA, and proposed structure of a mammalian hexokinase. Proc Natl Acad Sci U S A. 1989 Apr;86(8):2563–2567. doi: 10.1073/pnas.86.8.2563. [DOI] [PMC free article] [PubMed] [Google Scholar]
  118. Schwab D. A., Wilson J. E. Complete amino acid sequence of the type III isozyme of rat hexokinase, deduced from the cloned cDNA. Arch Biochem Biophys. 1991 Mar;285(2):365–370. doi: 10.1016/0003-9861(91)90373-q. [DOI] [PubMed] [Google Scholar]
  119. Schwab D. A., Wilson J. E. The complete amino acid sequence of the catalytic domain of rat brain hexokinase, deduced from the cloned cDNA. J Biol Chem. 1988 Mar 5;263(7):3220–3224. [PubMed] [Google Scholar]
  120. Scott V., Clark A. R., Hutton J. C., Docherty K. Two proteins act as the IUF1 insulin gene enhancer binding factor. FEBS Lett. 1991 Sep 23;290(1-2):27–30. doi: 10.1016/0014-5793(91)81217-v. [DOI] [PubMed] [Google Scholar]
  121. Shatton J. B., Morris H. P., Weinhouse S. Kinetic, electrophoretic, and chromatographic studies on glucose-ATP phosphotransferases in rat hepatomas. Cancer Res. 1969 Jun;29(6):1161–1172. [PubMed] [Google Scholar]
  122. Shelton K. D., Franklin A. J., Khoor A., Beechem J., Magnuson M. A. Multiple elements in the upstream glucokinase promoter contribute to transcription in insulinoma cells. Mol Cell Biol. 1992 Oct;12(10):4578–4589. doi: 10.1128/mcb.12.10.4578. [DOI] [PMC free article] [PubMed] [Google Scholar]
  123. Shulman G. I., Landau B. R. Pathways of glycogen repletion. Physiol Rev. 1992 Oct;72(4):1019–1035. doi: 10.1152/physrev.1992.72.4.1019. [DOI] [PubMed] [Google Scholar]
  124. Smith C. J., Vasta V., Degerman E., Belfrage P., Manganiello V. C. Hormone-sensitive cyclic GMP-inhibited cyclic AMP phosphodiesterase in rat adipocytes. Regulation of insulin- and cAMP-dependent activation by phosphorylation. J Biol Chem. 1991 Jul 15;266(20):13385–13390. [PubMed] [Google Scholar]
  125. Stachelek C., Stachelek J., Swan J., Botstein D., Konigsberg W. Identification, cloning and sequence determination of the genes specifying hexokinase A and B from yeast. Nucleic Acids Res. 1986 Jan 24;14(2):945–963. doi: 10.1093/nar/14.2.945. [DOI] [PMC free article] [PubMed] [Google Scholar]
  126. Stanley J. C., Dohm G. L., McManus B. S., Newsholme E. A. Activities of glucokinase and hexokinase in mammalian and avian livers. Biochem J. 1984 Dec 1;224(2):667–671. doi: 10.1042/bj2240667. [DOI] [PMC free article] [PubMed] [Google Scholar]
  127. Stoffel M., Froguel P., Takeda J., Zouali H., Vionnet N., Nishi S., Weber I. T., Harrison R. W., Pilkis S. J., Lesage S. Human glucokinase gene: isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7698–7702. doi: 10.1073/pnas.89.16.7698. [DOI] [PMC free article] [PubMed] [Google Scholar]
  128. Storer A. C., Cornish-Bowden A. Kinetic evidence for a 'mnemonical' mechanism for rat liver glucokinase. Biochem J. 1977 Jul 1;165(1):61–69. doi: 10.1042/bj1650061. [DOI] [PMC free article] [PubMed] [Google Scholar]
  129. Storer A. C., Cornish-Bowden A. Kinetics of rat liver glucokinase. Co-operative interactions with glucose at physiologically significant concentrations. Biochem J. 1976 Oct 1;159(1):7–14. doi: 10.1042/bj1590007. [DOI] [PMC free article] [PubMed] [Google Scholar]
  130. Storer A. C., Cornish-Bowden A. The kinetics of coupled enzyme reactions. Applications to the assay of glucokinase, with glucose 6-phosphate dehydrogenase as coupling enzyme. Biochem J. 1974 Jul;141(1):205–209. doi: 10.1042/bj1410205. [DOI] [PMC free article] [PubMed] [Google Scholar]
  131. Tal M., Liang Y., Najafi H., Lodish H. F., Matschinsky F. M. Expression and function of GLUT-1 and GLUT-2 glucose transporter isoforms in cells of cultured rat pancreatic islets. J Biol Chem. 1992 Aug 25;267(24):17241–17247. [PubMed] [Google Scholar]
  132. Tanizawa Y., Koranyi L. I., Welling C. M., Permutt M. A. Human liver glucokinase gene: cloning and sequence determination of two alternatively spliced cDNAs. Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7294–7297. doi: 10.1073/pnas.88.16.7294. [DOI] [PMC free article] [PubMed] [Google Scholar]
  133. Tanizawa Y., Matsutani A., Chiu K. C., Permutt M. A. Human glucokinase gene: isolation, structural characterization, and identification of a microsatellite repeat polymorphism. Mol Endocrinol. 1992 Jul;6(7):1070–1081. doi: 10.1210/mend.6.7.1354840. [DOI] [PubMed] [Google Scholar]
  134. Taylor W. E., Young E. T. cAMP-dependent phosphorylation and inactivation of yeast transcription factor ADR1 does not affect DNA binding. Proc Natl Acad Sci U S A. 1990 Jun;87(11):4098–4102. doi: 10.1073/pnas.87.11.4098. [DOI] [PMC free article] [PubMed] [Google Scholar]
  135. Teutsch H. F. Quantitative determination of G6Pase activity in histochemically defined zones of the liver acinus. Histochemistry. 1978 Dec 13;58(4):281–288. doi: 10.1007/BF00495384. [DOI] [PubMed] [Google Scholar]
  136. Thelen A. P., Wilson J. E. Complete amino acid sequence of the type II isozyme of rat hexokinase, deduced from the cloned cDNA: comparison with a hexokinase from novikoff ascites tumor. Arch Biochem Biophys. 1991 May 1;286(2):645–651. doi: 10.1016/0003-9861(91)90094-y. [DOI] [PubMed] [Google Scholar]
  137. Thompson K. S., Towle H. C. Localization of the carbohydrate response element of the rat L-type pyruvate kinase gene. J Biol Chem. 1991 May 15;266(14):8679–8682. [PubMed] [Google Scholar]
  138. Thorens B., Sarkar H. K., Kaback H. R., Lodish H. F. Cloning and functional expression in bacteria of a novel glucose transporter present in liver, intestine, kidney, and beta-pancreatic islet cells. Cell. 1988 Oct 21;55(2):281–290. doi: 10.1016/0092-8674(88)90051-7. [DOI] [PubMed] [Google Scholar]
  139. Tiedge M., Lenzen S. Regulation of glucokinase and GLUT-2 glucose-transporter gene expression in pancreatic B-cells. Biochem J. 1991 Nov 1;279(Pt 3):899–901. doi: 10.1042/bj2790899. [DOI] [PMC free article] [PubMed] [Google Scholar]
  140. Tippett P. S., Neet K. E. An allosteric model for the inhibition of glucokinase by long chain acyl coenzyme A. J Biol Chem. 1982 Nov 10;257(21):12846–12852. [PubMed] [Google Scholar]
  141. Tippett P. S., Neet K. E. Specific inhibition of glucokinase by long chain acyl coenzymes A below the critical micelle concentration. J Biol Chem. 1982 Nov 10;257(21):12839–12845. [PubMed] [Google Scholar]
  142. Trus M. D., Zawalich W. S., Burch P. T., Berner D. K., Weill V. A., Matschinsky F. M. Regulation of glucose metabolism in pancreatic islets. Diabetes. 1981 Nov;30(11):911–922. doi: 10.2337/diab.30.11.911. [DOI] [PubMed] [Google Scholar]
  143. Tóth B., Bollen M., Stalmans W. Acute regulation of hepatic protein phosphatases by glucagon, insulin, and glucose. J Biol Chem. 1988 Oct 5;263(28):14061–14066. [PubMed] [Google Scholar]
  144. Ureta T. The comparative isozymology of vertebrate hexokinases. Comp Biochem Physiol B. 1982;71(4):549–555. doi: 10.1016/0305-0491(82)90461-8. [DOI] [PubMed] [Google Scholar]
  145. VINUELA E., SALAS M., SOLS A. Glucokinase and hexokinase in liver in relation to glycogen synthesis. J Biol Chem. 1963 Mar;238:1175–1177. [PubMed] [Google Scholar]
  146. Van Schaftingen E., Davies D. R. Fructose administration stimulates glucose phosphorylation in the livers of anesthetized rats. FASEB J. 1991 Mar 1;5(3):326–330. doi: 10.1096/fasebj.5.3.2001793. [DOI] [PubMed] [Google Scholar]
  147. Vandercammen A., Detheux M., Van Schaftingen E. Binding of sorbitol 6-phosphate and of fructose 1-phosphate to the regulatory protein of liver glucokinase. Biochem J. 1992 Aug 15;286(Pt 1):253–256. doi: 10.1042/bj2860253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  148. Vandercammen A., Van Schaftingen E. The mechanism by which rat liver glucokinase is inhibited by the regulatory protein. Eur J Biochem. 1990 Jul 31;191(2):483–489. doi: 10.1111/j.1432-1033.1990.tb19147.x. [DOI] [PubMed] [Google Scholar]
  149. Velho G., Froguel P., Clement K., Pueyo M. E., Rakotoambinina B., Zouali H., Passa P., Cohen D., Robert J. J. Primary pancreatic beta-cell secretory defect caused by mutations in glucokinase gene in kindreds of maturity onset diabetes of the young. Lancet. 1992 Aug 22;340(8817):444–448. doi: 10.1016/0140-6736(92)91768-4. [DOI] [PubMed] [Google Scholar]
  150. Vionnet N., Stoffel M., Takeda J., Yasuda K., Bell G. I., Zouali H., Lesage S., Velho G., Iris F., Passa P. Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus. Nature. 1992 Apr 23;356(6371):721–722. doi: 10.1038/356721a0. [DOI] [PubMed] [Google Scholar]
  151. Vischer U., Blondel B., Wollheim C. B., Höppner W., Seitz H. J., Iynedjian P. B. Hexokinase isoenzymes of RIN-m5F insulinoma cells. Expression of glucokinase gene in insulin-producing cells. Biochem J. 1987 Jan 1;241(1):249–255. doi: 10.1042/bj2410249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  152. Waddell I. D., Burchell A. The microsomal glucose-6-phosphatase enzyme of pancreatic islets. Biochem J. 1988 Oct 15;255(2):471–476. doi: 10.1042/bj2550471. [DOI] [PMC free article] [PubMed] [Google Scholar]
  153. Watford M. Tissue-specific regulation of glucokinase. Trends Biochem Sci. 1990 Jan;15(1):1–2. doi: 10.1016/0968-0004(90)90113-p. [DOI] [PubMed] [Google Scholar]
  154. Weinhouse S. Regulation of glucokinase in liver. Curr Top Cell Regul. 1976;11:1–50. [PubMed] [Google Scholar]
  155. White T. K., Wilson J. E. Isolation and characterization of the discrete N- and C-terminal halves of rat brain hexokinase: retention of full catalytic activity in the isolated C-terminal half. Arch Biochem Biophys. 1989 Nov 1;274(2):375–393. doi: 10.1016/0003-9861(89)90451-7. [DOI] [PubMed] [Google Scholar]
  156. Williams T. F., Exton J. H., Park C. R., Regen D. M. Stereospecific transport of glucose in the perfused rat liver. Am J Physiol. 1968 Nov;215(5):1200–1209. doi: 10.1152/ajplegacy.1968.215.5.1200. [DOI] [PubMed] [Google Scholar]
  157. Yeldandi A. V., Tan X. D., Dwivedi R. S., Subbarao V., Smith D. D., Jr, Scarpelli D. G., Rao M. S., Reddy J. K. Coexpression of glutamine synthetase and carbamoylphosphate synthase I genes in pancreatic hepatocytes of rat. Proc Natl Acad Sci U S A. 1990 Feb;87(3):881–885. doi: 10.1073/pnas.87.3.881. [DOI] [PMC free article] [PubMed] [Google Scholar]
  158. van Schaftingen E., Vandercammen A., Detheux M., Davies D. R. The regulatory protein of liver glucokinase. Adv Enzyme Regul. 1992;32:133–148. doi: 10.1016/0065-2571(92)90013-p. [DOI] [PubMed] [Google Scholar]

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