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. 1993 Oct 1;295(Pt 1):15–18. doi: 10.1042/bj2950015

Decrease in cerebral inositols in rats and humans.

R A Moats 1, Y H Lien 1, D Filippi 1, B D Ross 1
PMCID: PMC1134813  PMID: 8216210

Abstract

Rats with portacaval shunts and humans with hepatic encephalopathy show severe myo-inositol depletion in the brain. The portacaval-shunted rat may therefore be a useful model for the investigation of neurochemical pathways containing myoinositol, which are modulated not only in hepatic encephalopathy but also in diabetes mellitus and Alzheimer's disease.

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Selected References

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