Table 2.

Estrogens in PCa treatment.

Route of Administration	Compound	Dosage	Ref.
Oral	Estradiol	1–2 mg 3×/day	[111]
	Conjugated estrogens	1.25–2.5 mg 3×/day	[112,113]
	Ethinylestradiol	0.15–3 mg/day	[112,113]
	Ethinylestradiol sulfonate	1–2 mg 1×/week	[114,115]
	DES	1–3 mg/day	[116]
	Dienestrol	5 mg/day	[117]
	Hexestrol	5 mg/day	[117]
	Fosfestrol	100–480 mg 1–3×/day	[118,119]
	Chlorotrianisene	12–48 mg/day	[120]
	Quadrosilan	900 mg/day	[117]
	Estramustine phosphate	140–1400 mg/day	[121]
Transdermal patch	Estradiol	2–6× 100 μg/day Scrotal: 1× 100 μg/day	[122,123]
Intramuscular or subcutaneous injection	Estradiol benzoate	1.66 mg 3×/week
	Estradiol dipropionate	5 mg 1×/week
	Estradiol valerate	10–40 mg 1×/1–2 weeks	[89,124]
	Estradiol undecylate	100 mg 1×/4 weeks	[125]
	Polyestradiol phosphate	Alone: 160–320 mg 1×/4 weeks With oral EE: 40–80 mg 1×/4 weeks	[126,127]
	Estrone	2–4 mg 2–3×/week	[91]
Intravenous injection	Fosfestrol	300–1200 mg 1–7×/week	[118,119]
	Estramustine phosphate	240–450 mg/day	[128]