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. 2024 Jul 24;14(8):893. doi: 10.3390/biom14080893

Figure 3.

Figure 3

Blood metabolic panel based on n = 8 Agl−/− mice treated with 10% DMSO vehicle (KO/Veh), n = 6 wild type mice treated with vehicle (WT/Veh), and n = 10 Agl−/− mice treated with GHF-201, as indicated. At all time points, GHF-201 significantly reduced alanine transferase and creatine phosphokinase, demonstrating partial restoration of liver and muscle damages, respectively. Additionally, blood glucose was increased, and blood triglycerides were decreased by GHF-201 in treated Agl−/− mice. Statistical significance between KO/Veh and KO/GHF-201 at the different time points was determined by Two Way ANOVA with repeated measures with a Tukey post hoc test according to simple effects within rows (i.e., times). *, 0.01 < p < 0.05; **, 0.001 < p < 0.01; ***, p < 0.001.