Abstract
The physiological role of D-amino acid oxidase was investigated by using mutant ddY/DAO- mice lacking the enzyme. Free D-amino acid concentrations in the mutant mice were significantly higher than those of control ddY/DAO+ mice in kidney, liver, lung, heart, brain, erythrocytes, serum and urine. The results suggest that the enzyme is involved in the catabolism of free D-amino acids in the body, and that free D-amino acids are also excreted into urine.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- BURCH H. B., LOWRY O. H., DE GUBAREFF T., LOWRY S. R. Flavin enzymes in liver and kidney of rats from birth to weaning. J Cell Physiol. 1958 Dec;52(3):503–510. doi: 10.1002/jcp.1030520308. [DOI] [PubMed] [Google Scholar]
- Fitzpatrick P. F., Massey V. Thiazolidine-2-carboxylic acid, an adduct of cysteamine and glyoxylate, as a substrate for D-amino acid oxidase. J Biol Chem. 1982 Feb 10;257(3):1166–1171. [PubMed] [Google Scholar]
- Gilbert S. F., Migeon B. R. D-valine as a selective agent for normal human and rodent epithelial cells in culture. Cell. 1975 May;5(1):11–17. doi: 10.1016/0092-8674(75)90086-0. [DOI] [PubMed] [Google Scholar]
- HOEPRICH P. D. ALANINE: CYCLOSERINE ANTAGONISM. VI. DEMONSTRATION OF D-ALANINE IN THE SERUM OF GUINEA PIGS AND MICE. J Biol Chem. 1965 Apr;240:1654–1660. [PubMed] [Google Scholar]
- Hamilton G. A., Buckthal D. J., Mortensen R. M., Zerby K. W. Reactions of cysteamine and other amine metabolites with glyoxylate and oxygen catalyzed by mammalian D-amino acid oxidase. Proc Natl Acad Sci U S A. 1979 Jun;76(6):2625–2629. doi: 10.1073/pnas.76.6.2625. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Konno R., Yasumura Y. Brain and kidney D-amino acid oxidases are coded by a single gene in the mouse. J Neurochem. 1984 Feb;42(2):584–586. doi: 10.1111/j.1471-4159.1984.tb02718.x. [DOI] [PubMed] [Google Scholar]
- Konno R., Yasumura Y. Involvement of D-amino-acid oxidase in D-amino acid utilization in the mouse. J Nutr. 1984 Sep;114(9):1617–1621. doi: 10.1093/jn/114.9.1617. [DOI] [PubMed] [Google Scholar]
- Konno R., Yasumura Y. Mouse mutant deficient in D-amino acid oxidase activity. Genetics. 1983 Feb;103(2):277–285. doi: 10.1093/genetics/103.2.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nagata Y., Akino T. D-amino acid oxidase in mouse liver. Comp Biochem Physiol B. 1988;89(1):179–182. doi: 10.1016/0305-0491(88)90280-5. [DOI] [PubMed] [Google Scholar]
- Nagata Y., Akino T., Ohno K., Kataoka Y., Ueda T., Sakurai T., Shiroshita K., Yasuda T. Free D-amino acids in human plasma in relation to senescence and renal diseases. Clin Sci (Lond) 1987 Jul;73(1):105–108. doi: 10.1042/cs0730105. [DOI] [PubMed] [Google Scholar]
- Nagata Y., Akino T., Ohno K. Microdetermination of serum D-amino acids. Anal Biochem. 1985 Oct;150(1):238–242. doi: 10.1016/0003-2697(85)90465-8. [DOI] [PubMed] [Google Scholar]