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. 1995 Aug 1;309(Pt 3):781–786. doi: 10.1042/bj3090781

Spermine induces haemoglobin synthesis in murine erythroleukaemia cells.

J G Delcros 1, B Schwartz 1, S Clément 1, H S Basu 1, L J Marton 1, B G Feuerstein 1
PMCID: PMC1135700  PMID: 7639693

Abstract

The naturally occurring polyamine spermine induces haemoglobin synthesis in murine erythroleukaemia (MEL) cells. Haemoglobin production was accompanied by accumulation of cytoplasmic beta-globin mRNA and growth inhibition, but not by cell-cycle block or changes in cell volume. Hexamethylene-bisacetamide (HMBA), a well known differentiating agent, also induces haemoglobin production, but causes a G1 block and decreases cell volume. These findings indicate that HMBA and spermine affect MEL cells differently, even though both induce haemoglobin production.

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Selected References

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