Table 1. Group and process in the experiment.

T2DM: type 2 diabetes mellitus; STZ: streptozotocin; HFD: high fat diet

Group	Experimental Treatment
	Establishment of T2DM	Establishment of Experimental Periodontitis
Blank Control Group (NC)	No (standard feed + intraperitoneal injection of saline)	No (5-0 silk ligature immediately removed after placement)
Experimental Periodontitis Group (NP)	No (standard feed + intraperitoneal injection of saline)	Yes (5-0 silk ligature, sustained for 6 weeks)
T2DM Group (ND)	Yes (HFD feeding for 4 weeks followed by intraperitoneal injection of 2% STZ)	No (5-0 silk ligature immediately removed after placement)
T2DM with Experimental Periodontitis Group (PD)	Yes (HFD feeding for 4 weeks followed by intraperitoneal injection of 2% STZ)	Yes (5-0 silk ligature, sustained for 6 weeks)