Retraction: Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3

Abstract

Chitinase 1 (CHIT1) plays a role in the pathogenesis of pulmonary fibrosis by modulating canonical and noncanonical TGF-β signaling via interaction with TGFBRAP1 and FOXO3. These findings highlight the CHIT1/SMAD7 axis as a potential biomarker and therapeutic target of pulmonary fibrosis.

Article: Lee C-M, He C-H, Park JW, Lee JH, Kamle S, Ma B, Akosman B, Cotez R, Chen E, Zhou Y, Herzog EL, Ryu C, Peng X, Rosas IO, Poli S, Bostwick CF, Choi AM, Elias JA, Lee CG (2019 May 13) Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3. Life Sci Alliance 2(3): e201900350. doi: 10.26508/lsa.201900350. PMID: 31085559.

The authors wish to retract this article because concerns have been raised regarding the contents and labeling of some of the figures in this article, including Figs 2D, 3A, and 4A. These figures appear to include duplicate data or to incorporate separate experiments that are not accurately labeled. Some of the immunoblot data cannot be verified from the records available. Although we believe that the conclusions of the article are still valid, in light of the inaccuracies in these figures, we consider that the appropriate course of action is to retract the article. All the authors agree with the retraction.