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. 1995 Dec 15;312(Pt 3):667–670. doi: 10.1042/bj3120667

Human papillomavirus type 6 E7 protein is a substrate in vitro of protein kinase C.

D J Armstrong 1, A Roman 1
PMCID: PMC1136165  PMID: 8554503

Abstract

The E7 proteins of 'low-risk' and 'high-risk' human papillomaviruses (HPV) are phosphorylated by casein kinase II. In this study, we report that the 'low-risk' HPV 6 E7 protein, but not the 'high-risk' HPV 16 E7 protein, can be phosphorylated in vitro on threonine at amino acid position 7 by protein kinase C. This is the first example of a qualitative biochemical difference between the HPV 6 E7 and HPV 16 E7 proteins.

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Selected References

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