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. 1995 Dec 15;312(Pt 3):713–716. doi: 10.1042/bj3120713

Identification of polymorphism at the glutathione S-transferase, GSTM3 locus: evidence for linkage with GSTM1*A.

A Inskip 1, J Elexperu-Camiruaga 1, N Buxton 1, P S Dias 1, J MacIntosh 1, D Campbell 1, P W Jones 1, L Yengi 1, J A Talbot 1, R C Strange 1, et al.
PMCID: PMC1136172  PMID: 8554510

Abstract

Allelism in the glutathione S-transferase, GSTM3 gene has been identified using PCR with specific primers to exon 6/exon 7. Sequencing showed the mutant GSTM3*B allele to have a three-base deletion in intron 6 with a frequency of 0.158. The mutation generates a recognition sequence, 5'-AAGATA-3', for the negative transcription factor YY1. GSTM3*B was significantly associated with GSTM1*A.

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Selected References

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  1. Albertini A. M., Hofer M., Calos M. P., Miller J. H. On the formation of spontaneous deletions: the importance of short sequence homologies in the generation of large deletions. Cell. 1982 Jun;29(2):319–328. doi: 10.1016/0092-8674(82)90148-9. [DOI] [PubMed] [Google Scholar]
  2. Bell D. A., Taylor J. A., Paulson D. F., Robertson C. N., Mohler J. L., Lucier G. W. Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer. J Natl Cancer Inst. 1993 Jul 21;85(14):1159–1164. doi: 10.1093/jnci/85.14.1159. [DOI] [PubMed] [Google Scholar]
  3. Campbell E., Takahashi Y., Abramovitz M., Peretz M., Listowsky I. A distinct human testis and brain mu-class glutathione S-transferase. Molecular cloning and characterization of a form present even in individuals lacking hepatic type mu isoenzymes. J Biol Chem. 1990 Jun 5;265(16):9188–9193. [PubMed] [Google Scholar]
  4. Comstock K. E., Widersten M., Hao X. Y., Henner W. D., Mannervik B. A comparison of the enzymatic and physicochemical properties of human glutathione transferase M4-4 and three other human Mu class enzymes. Arch Biochem Biophys. 1994 Jun;311(2):487–495. doi: 10.1006/abbi.1994.1266. [DOI] [PubMed] [Google Scholar]
  5. Hariharan N., Kelley D. E., Perry R. P. Delta, a transcription factor that binds to downstream elements in several polymerase II promoters, is a functionally versatile zinc finger protein. Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9799–9803. doi: 10.1073/pnas.88.21.9799. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Heagerty A. H., Fitzgerald D., Smith A., Bowers B., Jones P., Fryer A. A., Zhao L., Alldersea J., Strange R. C. Glutathione S-transferase GSTM1 phenotypes and protection against cutaneous tumours. Lancet. 1994 Jan 29;343(8892):266–268. doi: 10.1016/s0140-6736(94)91115-0. [DOI] [PubMed] [Google Scholar]
  7. Nakachi K., Imai K., Hayashi S., Watanabe J., Kawajiri K. Genetic susceptibility to squamous cell carcinoma of the lung in relation to cigarette smoking dose. Cancer Res. 1991 Oct 1;51(19):5177–5180. [PubMed] [Google Scholar]
  8. Nakajima T., Elovaara E., Anttila S., Hirvonen A., Camus A. M., Hayes J. D., Ketterer B., Vainio H. Expression and polymorphism of glutathione S-transferase in human lungs: risk factors in smoking-related lung cancer. Carcinogenesis. 1995 Apr;16(4):707–711. doi: 10.1093/carcin/16.4.707. [DOI] [PubMed] [Google Scholar]
  9. Pearson W. R., Vorachek W. R., Xu S. J., Berger R., Hart I., Vannais D., Patterson D. Identification of class-mu glutathione transferase genes GSTM1-GSTM5 on human chromosome 1p13. Am J Hum Genet. 1993 Jul;53(1):220–233. [PMC free article] [PubMed] [Google Scholar]
  10. Shi Y., Seto E., Chang L. S., Shenk T. Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein. Cell. 1991 Oct 18;67(2):377–388. doi: 10.1016/0092-8674(91)90189-6. [DOI] [PubMed] [Google Scholar]
  11. Strange R. C., Fryer A. A., Matharoo B., Zhao L., Broome J., Campbell D. A., Jones P., Pastor I. C., Singh R. V. The human glutathione S-transferases: comparison of isoenzyme expression in normal and astrocytoma brain. Biochim Biophys Acta. 1992 Jul 7;1139(3):222–228. doi: 10.1016/0925-4439(92)90138-d. [DOI] [PubMed] [Google Scholar]
  12. Suzuki T., Coggan M., Shaw D. C., Board P. G. Electrophoretic and immunological analysis of human glutathione S-transferase isozymes. Ann Hum Genet. 1987 May;51(Pt 2):95–106. doi: 10.1111/j.1469-1809.1987.tb01051.x. [DOI] [PubMed] [Google Scholar]
  13. Taylor J. B., Oliver J., Sherrington R., Pemble S. E. Structure of human glutathione S-transferase class Mu genes. Biochem J. 1991 Mar 1;274(Pt 2):587–593. doi: 10.1042/bj2740587. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Watanabe J., Hayashi S., Kawajiri K. Different regulation and expression of the human CYP2E1 gene due to the RsaI polymorphism in the 5'-flanking region. J Biochem. 1994 Aug;116(2):321–326. doi: 10.1093/oxfordjournals.jbchem.a124526. [DOI] [PubMed] [Google Scholar]
  15. Wolf C. R., Smith C. A., Forman D. Metabolic polymorphisms in carcinogen metabolising enzymes and cancer susceptibility. Br Med Bull. 1994 Jul;50(3):718–731. doi: 10.1093/oxfordjournals.bmb.a072920. [DOI] [PubMed] [Google Scholar]
  16. Zhong S., Spurr N. K., Hayes J. D., Wolf C. R. Deduced amino acid sequence, gene structure and chromosomal location of a novel human class Mu glutathione S-transferase, GSTM4. Biochem J. 1993 Apr 1;291(Pt 1):41–50. doi: 10.1042/bj2910041. [DOI] [PMC free article] [PubMed] [Google Scholar]

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