Table 1.

Microbial strains for next generation probiotics.

S.No	Strain	Host	Benefit	Clinal Trails	References
1.	Bacteroides fragilis	Human feces	Enhances phagocytosis and polarises M1 macrophages	LoVo cells	[22]
2.	Bacteroides dorei	Human feces	Cholesterol reducing	Human	[21]
3.	Bacteroides ovatus	Human Gut	Reduces Intestinal Inflammation	Mice	[27]
4.	Bacteroides ovatus	–	Reduces Intestinal Inflammation	Mice	[28]
5.	Lactococcus lactis	GMO(Food)	Reduces inflammatory bowel diseases	Mice	[29]
6.	Faecalibacterium prausnitzii	Human feces	Mainly IBD, but also asthma, eczema and Type II diabete	Human	[[30], [31], [32]]
7.	Bacteroides ovatus	Human feces	Reduces the risk of certain types of cancer	–	[33]
8.	Clostridium butyricm	Human	Prevention of pouchitis and alteration of the microbiota profile in patients with ulcerative colitis	Human	[23]
9.	Bacteroides acidifaciens	Mouse feces	Clearance of infectious agents	–	[34]
10.	Oscillospira sp.	Human Gut	Improved diabetes, obesity and reduced systematic chronic inflammation	–	[35]
11.	Akkermansia muciniphila	Human Gut	Improves key components of metabolic syndrome, such as reducing fat mass, plasma glucose, gut permeability and metabolic inflammation	Mice	[36]
12.	Bacteroides fragilis	Human feces	Antibiotic-associated diarrhea	Rat	[25]
13.	Bacteroides fragilis	Human Gut	Oxazolone-induced experimental colitis	Mice	[37]
14.	Bacteroides fragilis	Human feces	Vibrio parahaemolyticus infection	Mice	[24]
15.	Bacteroides uniformis	Human feces	Overweight-associated disorders	Mice	[38]
16.	Akkermansia muciniphila	Human Gut	Develop live biotherapeutic product	–	[39]
17.	Ruminococcus bromii	Human Gut	Develop live biotherapeutic product	–	[39]
18.	Faecalibacterium prausnitzii	Human Gut	Develop live biotherapeutic product	–	[39]
19.	Anaerobutyricum hallii	Human Gut	Develop live biotherapeutic product	–	[39]
20.	Roseburia intestinalis	Human Gut	Develop live biotherapeutic product	–	[39]
21.	Faecalibacterium prausnitzii	Human gut	Reduced in patients with hyperlipidaemia, prediabetes and type 2 diabetes, non-alcoholic fatty liver diseaseand inflammatory bowel disease	Mice and Human	[40]
22.	Lactococcus lactis	Fecal	Induced Parkinsonism are mediated by modulating oxidative stress, inhibiting ferroptosis, and redressing dysbiosis	Human	[26]
23.	Bifidobacterium sp.		Promotes antitumor immunity and facilitates anti–PD-L1 efficacy	Mice	[41]
24.	Bifidobacterium longum	Human Blood	Robust CD8+ T cell response and better prognosis in HBV-related hepatocellular carcinoma	Human	[42]
25.	Enterococcus hirae	Human Blood	Robust CD8+ T cell response and better prognosis in HBV-related hepatocellular carcinoma	Human	[42]
26.	Lactobacillus rhamnosus	Human blood	Improve immune system	Human	[43]
27.	Bifidobacterium lactis	Human blood	Improve immune system	Human	[43]
28.	Akkermansia muciniphila	–	Combat cancer disease	Mice	[44]
29.	Faecalibacterium prausnitzii	Human	Anti-tumor response	Mice	[45]
30.	Akkermansia muciniphila	–	Reducing systematic inflammation and potentially lowering cancer risk	Human	[46]
31.	Clostridium butyricum	Stool samples	CBM reduced the changes in the intestinal flora and decreased the incidence of gastrointestinal side effects	–	[47]
32.	Clostridium butyricum	–	Showed Antitumor effects by enhancing the release of TRAIL from neutrophils through MMP-8 and novel intravesical therapy for bladder cancer	Human	[48]
33.	Clostridium butyricum	–	Reduces the incidence of diarrhea in digestive diseases, including inflammatory bowel disease	Human	[49]
34.	Eubacterium limosum		Increases mucosal integrity and shows anti-inflammatory action modulation of mucosal defense system via TLR4	Mice	[50]
35.	Eubacterium hallii	–	Improves insulin sensitivity and increases energy metabolism in severely obese and diabetic	Mice	[51]
36.	Akkermansia muciniphila	–	Enhance the efficacy of cancer immunotherapy's	Mice	[52]
37.	Enterococcus hirae	–	Th1 Cell Immune Responses in Chemotherapy-Treated Cancer	Mice	[53]
38.	Barnesiellaintestinihominis	–	Th1 Cell Immune Responses in Chemotherapy-Treated Cancer	Mice	[53]
39.	Bacteroides fragilis	Feces of a healthy breast-fed infant	Enhances the phagocytic functions of macrophages, polarising them to an M1 phenotype		[22]