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. 1994 Jul 15;301(Pt 2):313–316. doi: 10.1042/bj3010313

Uptake of nitric oxide synthase inhibitors by macrophage RAW 264.7 cells.

K Schmidt 1, P Klatt 1, B Mayer 1
PMCID: PMC1137080  PMID: 7519006

Abstract

Uptake of the nitric oxide synthase inhibitors NG-methyl-L-arginine (L-NMA) and NG-nitro-L-arginine (L-NNA) by macrophages is mediated by two different mechanisms. Activation of the cells with cytokines resulted in an up-regulation of L-NMA uptake but did not affect L-NNA transport. Characterization of the transport sites revealed that uptake of L-NMA is mediated by a cationic amino acid transporter (system y+) whereas a neutral amino acid transporter (system L) accounts for the uptake of L-NNA.

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Selected References

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