Skip to main content
Biochemical Journal logoLink to Biochemical Journal
. 1993 Nov 15;296(Pt 1):1–14. doi: 10.1042/bj2960001

Calcium: its modulation in liver by cross-talk between the actions of glucagon and calcium-mobilizing agonists.

F L Bygrave 1, A Benedetti 1
PMCID: PMC1137647  PMID: 8250828

Full text

PDF
1

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abdel-Latif A. A. Biochemical and functional interactions between the inositol 1,4,5-trisphosphate-Ca2+ and cyclic AMP signalling systems in smooth muscle. Cell Signal. 1991;3(5):371–385. doi: 10.1016/0898-6568(91)90068-6. [DOI] [PubMed] [Google Scholar]
  2. Abou-Samra A. B., Jüppner H., Force T., Freeman M. W., Kong X. F., Schipani E., Urena P., Richards J., Bonventre J. V., Potts J. T., Jr Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2732–2736. doi: 10.1073/pnas.89.7.2732. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Althaus-Salzmann M., Carafoli E., Jakob A. Ca2+, K+ redistributions and alpha-adrenergic activation of glycogenolysis in perfused rat livers. Eur J Biochem. 1980 May;106(1):241–248. doi: 10.1111/j.1432-1033.1980.tb06015.x. [DOI] [PubMed] [Google Scholar]
  4. Altin J. G., Bygrave F. L. Ca2+ uptake stimulated by the synergistic action of glucagon and Ca2+-mobilizing agents in the perfused rat liver occurs through the activation of a unidirectional Ca2+ influx pathway. Biochem Biophys Res Commun. 1987 Feb 13;142(3):745–753. doi: 10.1016/0006-291x(87)91477-x. [DOI] [PubMed] [Google Scholar]
  5. Altin J. G., Bygrave F. L. Phosphatidic acid and arachidonic acid each interact synergistically with glucagon to stimulate Ca2+ influx in the perfused rat liver. Biochem J. 1987 Nov 1;247(3):613–619. doi: 10.1042/bj2470613. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Altin J. G., Bygrave F. L. Second messengers and the regulation of Ca2+ fluxes by Ca2+-mobilizing agonists in rat liver. Biol Rev Camb Philos Soc. 1988 Nov;63(4):551–611. doi: 10.1111/j.1469-185x.1988.tb00670.x. [DOI] [PubMed] [Google Scholar]
  7. Altin J. G., Bygrave F. L. Synergistic stimulation of Ca2+ uptake by glucagon and Ca2+-mobilizing hormones in the perfused rat liver. A role for mitochondria in long-term Ca2+ homoeostasis. Biochem J. 1986 Sep 15;238(3):653–661. doi: 10.1042/bj2380653. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Altin J. G., Bygrave F. L. The Ca2+-mobilizing actions of vasopressin and angiotensin differ from those of the alpha-adrenergic agonist phenylephrine in the perfused rat liver. Biochem J. 1985 Dec 15;232(3):911–917. doi: 10.1042/bj2320911. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Altin J. G., Bygrave F. L. The influx of Ca2+ induced by the administration of glucagon and Ca2+-mobilizing agents to the perfused rat liver could involve at least two separate pathways. Biochem J. 1987 Feb 15;242(1):43–50. doi: 10.1042/bj2420043. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Andia-Waltenbaugh A. M., Tate C. A., Friedmann N. K. The effect of glucagon on the kinetics of hepatic mitochondrial calcium uptake. Mol Cell Biochem. 1981 May 26;36(3):177–184. doi: 10.1007/BF02357035. [DOI] [PubMed] [Google Scholar]
  11. Assimacopoulos-Jeannet F. D., Blackmore P. F., Exton J. H. Studies of the interaction between glucagon and alpha-adrenergic agonists in the control of hepatic glucose output. J Biol Chem. 1982 Apr 10;257(7):3759–3765. [PubMed] [Google Scholar]
  12. Assimacopoulos-Jeannet F. D., Blackmore P. F., Exton J. H. Studies on alpha-adrenergic activation of hepatic glucose output. Studies on role of calcium in alpha-adrenergic activation of phosphorylase. J Biol Chem. 1977 Apr 25;252(8):2662–2669. [PubMed] [Google Scholar]
  13. Assimacopoulos-Jeannet F., McCormack J. G., Jeanrenaud B. Vasopressin and/or glucagon rapidly increases mitochondrial calcium and oxidative enzyme activities in the perfused rat liver. J Biol Chem. 1986 Jul 5;261(19):8799–8804. [PubMed] [Google Scholar]
  14. Barritt G. J., Hughes B. P. The nature and mechanism of activation of the hepatocyte receptor-activated Ca2+ inflow system. Cell Signal. 1991;3(4):283–292. doi: 10.1016/0898-6568(91)90056-z. [DOI] [PubMed] [Google Scholar]
  15. Barritt G. J., Parker J. C., Wadsworth J. C. A kinetic analysis of the effects of adrenaline on calcium distribution in isolated rat liver parenchymal cells. J Physiol. 1981 Mar;312:29–55. doi: 10.1113/jphysiol.1981.sp013614. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Benedetti A., Fulceri R., Comporti M. Calcium sequestration activity in rat liver microsomes. Evidence for a cooperation of calcium transport with glucose-6-phosphatase. Biochim Biophys Acta. 1985 Jun 27;816(2):267–277. doi: 10.1016/0005-2736(85)90494-8. [DOI] [PubMed] [Google Scholar]
  17. Benedetti A., Fulceri R., Romani A., Comporti M. MgATP-dependent glucose 6-phosphate-stimulated Ca2+ accumulation in liver microsomal fractions. Effects of inositol 1,4,5-trisphosphate and GTP. J Biol Chem. 1988 Mar 5;263(7):3466–3473. [PubMed] [Google Scholar]
  18. Benedetti A., Fulceri R., Romani A., Comporti M. Stimulatory effect of glucose 6-phosphate on the non-mitochondrial Ca2+ uptake in permeabilized hepatocytes and Ca2+ release by inositol trisphosphate. Biochim Biophys Acta. 1987 May 18;928(3):282–286. doi: 10.1016/0167-4889(87)90187-x. [DOI] [PubMed] [Google Scholar]
  19. Benedetti A., Graf P., Fulceri R., Romani A., Sies H. Ca2+ mobilization by vasopressin and glucagon in perfused livers. Effect of prior intoxication with bromotrichloromethane. Biochem Pharmacol. 1989 Jun 1;38(11):1799–1805. doi: 10.1016/0006-2952(89)90415-2. [DOI] [PubMed] [Google Scholar]
  20. Berridge M. J. Inositol trisphosphate and diacylglycerol: two interacting second messengers. Annu Rev Biochem. 1987;56:159–193. doi: 10.1146/annurev.bi.56.070187.001111. [DOI] [PubMed] [Google Scholar]
  21. Blackmore P. F., Brumley F. T., Marks J. L., Exton J. H. Studies on alpha-adrenergic activation of hepatic glucose output. Relationship between alpha-adrenergic stimulation of calcium efflux and activation of phosphorylase in isolated rat liver parenchymal cells. J Biol Chem. 1978 Jul 25;253(14):4851–4858. [PubMed] [Google Scholar]
  22. Blackmore P. F., Exton J. H. Studies on the hepatic calcium-mobilizing activity of aluminum fluoride and glucagon. Modulation by cAMP and phorbol myristate acetate. J Biol Chem. 1986 Aug 25;261(24):11056–11063. [PubMed] [Google Scholar]
  23. Blackmore P. F., Waynick L. E., Blackman G. E., Graham C. W., Sherry R. S. Alpha- and beta-adrenergic stimulation of parenchymal cell Ca2+ influx. Influence of extracellular pH. J Biol Chem. 1984 Oct 25;259(20):12322–12325. [PubMed] [Google Scholar]
  24. Bond M., Vadasz G., Somlyo A. V., Somlyo A. P. Subcellular calcium and magnesium mobilization in rat liver stimulated in vivo with vasopressin and glucagon. J Biol Chem. 1987 Nov 15;262(32):15630–15636. [PubMed] [Google Scholar]
  25. Borle A. B. Control, Modulation, and regulation of cell calcium. Rev Physiol Biochem Pharmacol. 1981;90:13–153. doi: 10.1007/BFb0034078. [DOI] [PubMed] [Google Scholar]
  26. Borle A. B. Kinetic analysis of calcium movements in cell culture. V. Intracellular calcium distribution in kidney cells. J Membr Biol. 1972;10(1):45–66. doi: 10.1007/BF01867847. [DOI] [PubMed] [Google Scholar]
  27. Borle A. B., Snowdowne K. W. Measurement of intracellular ionized calcium with aequorin. Methods Enzymol. 1986;124:90–116. doi: 10.1016/0076-6879(86)24011-2. [DOI] [PubMed] [Google Scholar]
  28. Brown A. M. A cellular logic for G protein-coupled ion channel pathways. FASEB J. 1991 May;5(8):2175–2179. doi: 10.1096/fasebj.5.8.1708737. [DOI] [PubMed] [Google Scholar]
  29. Burgess G. M., Bird G. S., Obie J. F., Putney J. W., Jr The mechanism for synergism between phospholipase C- and adenylylcyclase-linked hormones in liver. Cyclic AMP-dependent kinase augments inositol trisphosphate-mediated Ca2+ mobilization without increasing the cellular levels of inositol polyphosphates. J Biol Chem. 1991 Mar 15;266(8):4772–4781. [PubMed] [Google Scholar]
  30. Burgess G. M., Dooley R. K., McKinney J. S., Nånberg E., Putney J. W., Jr Further studies on the interactions between the calcium mobilization and cyclic AMP pathways in guinea pig hepatocytes. Mol Pharmacol. 1986 Oct;30(4):315–320. [PubMed] [Google Scholar]
  31. Bygrave F. L., Gamberucci A., Fulceri R., Benedetti A. Evidence that stimulation of plasma-membrane Ca2+ inflow is an early action of glucagon and dibutyryl cyclic AMP in rat hepatocytes. Biochem J. 1993 May 15;292(Pt 1):19–22. doi: 10.1042/bj2920019. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Bygrave F. L., Lenton L., Altin J. G., Setchell B. A., Karjalainen A. Phosphate and calcium uptake by mitochondria and by perfused rat liver induced by the synergistic action of glucagon and vasopressin. Biochem J. 1990 Apr 1;267(1):69–73. doi: 10.1042/bj2670069. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Bygrave F. L. Mitochondria and the control of intracellular calcium. Biol Rev Camb Philos Soc. 1978 Feb;53(1):43–79. doi: 10.1111/j.1469-185x.1978.tb00992.x. [DOI] [PubMed] [Google Scholar]
  34. Bygrave F. L. Studies on the interaction of metal ions with pyruvate kinase from Ehrlich ascites-tumour cells and from rabbit muscle. Biochem J. 1966 Nov;101(2):488–494. doi: 10.1042/bj1010488. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Bygrave F. L. The ionic environment and metabolic control. Nature. 1967 May 13;214(5089):667–671. doi: 10.1038/214667a0. [DOI] [PubMed] [Google Scholar]
  36. Bygrave F. L., Tranter C. J. The subcellular location, maturation and response to increased plasma glucagon of ruthenium red-insensitive calcium-ion transport in rat liver. Biochem J. 1978 Sep 15;174(3):1021–1030. doi: 10.1042/bj1741021. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Bànhegyi G., Fulceri R., Bellomo G., Romani A., Pompella A., Benedetti A. Role of a nonmitochondrial Ca2+ pool in the synergistic stimulation by cyclic AMP and vasopressin of Ca2+ uptake in isolated rat hepatocytes. Arch Biochem Biophys. 1991 Jun;287(2):320–328. doi: 10.1016/0003-9861(91)90485-2. [DOI] [PubMed] [Google Scholar]
  38. Bühler H. U., da Prada M., Haefely W., Picotti G. B. Plasma adrenaline, noradrenaline and dopamine in man and different animal species. J Physiol. 1978 Mar;276:311–320. doi: 10.1113/jphysiol.1978.sp012235. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Capiod T., Noel J., Combettes L., Claret M. Cyclic AMP-evoked oscillations of intracellular [Ca2+] in guinea-pig hepatocytes. Biochem J. 1991 Apr 1;275(Pt 1):277–280. doi: 10.1042/bj2750277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Chabre O., Conklin B. R., Lin H. Y., Lodish H. F., Wilson E., Ives H. E., Catanzariti L., Hemmings B. A., Bourne H. R. A recombinant calcitonin receptor independently stimulates 3',5'-cyclic adenosine monophosphate and Ca2+/inositol phosphate signaling pathways. Mol Endocrinol. 1992 Apr;6(4):551–556. doi: 10.1210/mend.6.4.1316547. [DOI] [PubMed] [Google Scholar]
  41. Charest R., Blackmore P. F., Berthon B., Exton J. H. Changes in free cytosolic Ca2+ in hepatocytes following alpha 1-adrenergic stimulation. Studies on Quin-2-loaded hepatocytes. J Biol Chem. 1983 Jul 25;258(14):8769–8773. [PubMed] [Google Scholar]
  42. Charest R., Blackmore P. F., Exton J. H. Characterization of responses of isolated rat hepatocytes to ATP and ADP. J Biol Chem. 1985 Dec 15;260(29):15789–15794. [PubMed] [Google Scholar]
  43. Charest R., Prpić V., Exton J. H., Blackmore P. F. Stimulation of inositol trisphosphate formation in hepatocytes by vasopressin, adrenaline and angiotensin II and its relationship to changes in cytosolic free Ca2+. Biochem J. 1985 Apr 1;227(1):79–90. doi: 10.1042/bj2270079. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Claret-Berthon B., Claret M., Mazet J. L. Fluxes and distribution of calcium in rat liver cells: kinetic analysis and identification of pools. J Physiol. 1977 Nov;272(3):529–552. doi: 10.1113/jphysiol.1977.sp012058. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Cockcroft S., Thomas G. M. Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors. Biochem J. 1992 Nov 15;288(Pt 1):1–14. doi: 10.1042/bj2880001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Cocks T. M., Jenkinson D. H., Koller K. Interactions between receptors that increase cytosolic calcium and cyclic AMP in guinea-pig liver cells. Br J Pharmacol. 1984 Sep;83(1):281–291. doi: 10.1111/j.1476-5381.1984.tb10144.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  47. Cohen P. Signal integration at the level of protein kinases, protein phosphatases and their substrates. Trends Biochem Sci. 1992 Oct;17(10):408–413. doi: 10.1016/0968-0004(92)90010-7. [DOI] [PubMed] [Google Scholar]
  48. Combettes L., Berthon B., Binet A., Claret M. Glucagon and vasopressin interactions on Ca2+ movements in isolated hepatocytes. Biochem J. 1986 Aug 1;237(3):675–683. doi: 10.1042/bj2370675. [DOI] [PMC free article] [PubMed] [Google Scholar]
  49. Comerford J. G., Dawson A. P. Effects of CoA and acyl-CoAs on GTP-dependent Ca2+ release and vesicle fusion in rat liver microsomal vesicles. Biochem J. 1993 Jan 15;289(Pt 2):561–567. doi: 10.1042/bj2890561. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Connelly P. A., Sisk R. B., Schulman H., Garrison J. C. Evidence for the activation of the multifunctional Ca2+/calmodulin-dependent protein kinase in response to hormones that increase intracellular Ca2+. J Biol Chem. 1987 Jul 25;262(21):10154–10163. [PubMed] [Google Scholar]
  51. Crane J. K., Campanile C. P., Garrison J. C. The hepatic angiotensin II receptor. II. Effect of guanine nucleotides and interaction with cyclic AMP production. J Biol Chem. 1982 May 10;257(9):4959–4965. [PubMed] [Google Scholar]
  52. Creba J. A., Downes C. P., Hawkins P. T., Brewster G., Michell R. H., Kirk C. J. Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones. Biochem J. 1983 Jun 15;212(3):733–747. doi: 10.1042/bj2120733. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Crofts J. N., Barritt G. J. The liver cell plasma membrane Ca2+ inflow systems exhibit a broad specificity for divalent metal ions. Biochem J. 1990 Aug 1;269(3):579–587. doi: 10.1042/bj2690579. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Crofts J. N., Barritt G. J. The measurement of Ca2+ inflow across the liver cell plasma membrane by using quin2 and studies of the roles of Na+ and extracellular Ca2+ in the mechanism of Ca2+ inflow. Biochem J. 1989 Nov 15;264(1):61–70. doi: 10.1042/bj2640061. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Dasso L. L., Taylor C. W. Different calcium-mobilizing receptors share the same guanine nucleotide-binding protein pool in hepatocytes. Mol Pharmacol. 1992 Sep;42(3):453–457. [PubMed] [Google Scholar]
  56. Denton R. M., McCormack J. G. Ca2+ transport by mammalian mitochondria and its role in hormone action. Am J Physiol. 1985 Dec;249(6 Pt 1):E543–E554. doi: 10.1152/ajpendo.1985.249.6.E543. [DOI] [PubMed] [Google Scholar]
  57. Eigler N., Saccà L., Sherwin R. S. Synergistic interactions of physiologic increments of glucagon, epinephrine, and cortisol in the dog: a model for stress-induced hyperglycemia. J Clin Invest. 1979 Jan;63(1):114–123. doi: 10.1172/JCI109264. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. Epping R. J., Bygrave F. L. A procedure for the rapid isolation from rat liver of plasma membrane vesicles exhibiting Ca2+-transport and Ca2+-ATPase activities. Biochem J. 1984 Nov 1;223(3):733–745. doi: 10.1042/bj2230733. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Exton J. H. Mechanisms involved in alpha-adrenergic phenomena. Am J Physiol. 1985 Jun;248(6 Pt 1):E633–E647. doi: 10.1152/ajpendo.1985.248.6.E633. [DOI] [PubMed] [Google Scholar]
  60. Exton J. H. Molecular mechanisms involved in alpha-adrenergic responses. Mol Cell Endocrinol. 1981 Sep;23(3):233–264. doi: 10.1016/0303-7207(81)90123-4. [DOI] [PubMed] [Google Scholar]
  61. Exton J. H. Signaling through phosphatidylcholine breakdown. J Biol Chem. 1990 Jan 5;265(1):1–4. [PubMed] [Google Scholar]
  62. Exton J. H. The perfused rat liver. Methods Enzymol. 1975;39:25–36. doi: 10.1016/s0076-6879(75)39006-x. [DOI] [PubMed] [Google Scholar]
  63. Exton J. H. The roles of calcium and phosphoinositides in the mechanisms of alpha 1-adrenergic and other agonists. Rev Physiol Biochem Pharmacol. 1988;111:117–224. doi: 10.1007/BFb0033873. [DOI] [PubMed] [Google Scholar]
  64. Ferris C. D., Cameron A. M., Bredt D. S., Huganir R. L., Snyder S. H. Inositol 1,4,5-trisphosphate receptor is phosphorylated by cyclic AMP-dependent protein kinase at serines 1755 and 1589. Biochem Biophys Res Commun. 1991 Feb 28;175(1):192–198. doi: 10.1016/s0006-291x(05)81219-7. [DOI] [PubMed] [Google Scholar]
  65. Freissmuth M., Casey P. J., Gilman A. G. G proteins control diverse pathways of transmembrane signaling. FASEB J. 1989 Aug;3(10):2125–2131. [PubMed] [Google Scholar]
  66. Friedmann N. Effects of glucagon and cyclic AMP on ion fluxes in the perfused liver. Biochim Biophys Acta. 1972 Jul 3;274(1):214–225. doi: 10.1016/0005-2736(72)90295-7. [DOI] [PubMed] [Google Scholar]
  67. Friedmann N., Park C. R. Early effects of 3',5'-adenosine monophosphate on the fluxes of calcium end potassium in the perfused liver of normal and adrenalectomized rats. Proc Natl Acad Sci U S A. 1968 Oct;61(2):504–508. doi: 10.1073/pnas.61.2.504. [DOI] [PMC free article] [PubMed] [Google Scholar]
  68. Fulceri R., Bellomo G., Gamberucci A., Benedetti A. MgATP-dependent accumulation of calcium ions and inorganic phosphate in a liver reticular pool. Biochem J. 1990 Dec 1;272(2):549–552. doi: 10.1042/bj2720549. [DOI] [PMC free article] [PubMed] [Google Scholar]
  69. Fulceri R., Bellomo G., Mirabelli F., Gamberucci A., Benedetti A. Measurement of mitochondrial and non-mitochondrial Ca2+ in isolated intact hepatocytes: a critical re-evaluation of the use of mitochondrial inhibitors. Cell Calcium. 1991 Jun;12(6):431–439. doi: 10.1016/0143-4160(91)90069-q. [DOI] [PubMed] [Google Scholar]
  70. García-Sáinz J. A., Mendlovic F., Martínez-Olmedo M. A. Effects of phorbol esters on alpha 1-adrenergic-mediated and glucagon-mediated actions in isolated rat hepatocytes. Biochem J. 1985 May 15;228(1):277–280. doi: 10.1042/bj2280277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  71. Garrison J. C. The effects of glucagon, catecholamines, and the calcium ionophore A23187 on the phosphorylation of rat hepatocyte cytosolic proteins. J Biol Chem. 1978 Oct 10;253(19):7091–7100. [PubMed] [Google Scholar]
  72. Gevers W., Krebs H. A. The effects of adenine nucleotides on carbohydrate metabolism in pigeon-liver homogenates. Biochem J. 1966 Mar;98(3):720–735. doi: 10.1042/bj0980720. [DOI] [PMC free article] [PubMed] [Google Scholar]
  73. Glennon M. C., Bird G. S., Kwan C. Y., Putney J. W., Jr Actions of vasopressin and the Ca(2+)-ATPase inhibitor, thapsigargin, on Ca2+ signaling in hepatocytes. J Biol Chem. 1992 Apr 25;267(12):8230–8233. [PubMed] [Google Scholar]
  74. Graf P., vom Dahl S., Sies H. Sustained oscillations in extracellular calcium concentrations upon hormonal stimulation of perfused rat liver. Biochem J. 1987 Feb 1;241(3):933–936. doi: 10.1042/bj2410933. [DOI] [PMC free article] [PubMed] [Google Scholar]
  75. Hamada Y., Karjalainen A., Setchell B. A., Millard J. E., Bygrave F. L. Acute effects of cholestatic and choleretic bile salts on vasopressin- and glucagon-induced hepato-biliary calcium fluxes in the perfused rat liver. Biochem J. 1992 Apr 15;283(Pt 2):575–581. doi: 10.1042/bj2830575. [DOI] [PMC free article] [PubMed] [Google Scholar]
  76. Hamada Y., Karjalainen A., Setchell B. A., Millard J. E., Bygrave F. L. Concomitant stimulation by vasopressin of biliary and perfusate calcium fluxes in the perfused rat liver. Biochem J. 1992 Jan 15;281(Pt 2):387–392. doi: 10.1042/bj2810387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  77. Hansen C. A., Yang L. J., Williamson J. R. Mechanisms of receptor-mediated Ca2+ signaling in rat hepatocytes. J Biol Chem. 1991 Oct 5;266(28):18573–18579. [PubMed] [Google Scholar]
  78. Holz G. G., Habener J. F. Signal transduction crosstalk in the endocrine system: pancreatic beta-cells and the glucose competence concept. Trends Biochem Sci. 1992 Oct;17(10):388–393. doi: 10.1016/0968-0004(92)90006-u. [DOI] [PMC free article] [PubMed] [Google Scholar]
  79. Houslay M. D., Griffiths S. L., Horton Y. M., Livingstone C., Lobban M., Macdonald F., Morris N., Pryde J., Scotland G., Shakur Y. Regulation of intracellular cyclic AMP concentrations in hepatocytes involves the integrated activation and desensitization of adenylyl cyclase coupled with the action and activation of specific isoforms of cyclic AMP phosphodiesterase. Biochem Soc Trans. 1992 Feb;20(1):140–146. doi: 10.1042/bst0200140. [DOI] [PubMed] [Google Scholar]
  80. Hughes B. P., Crofts J. N., Auld A. M., Read L. C., Barritt G. J. Evidence that a pertussis-toxin-sensitive substrate is involved in the stimulation by epidermal growth factor and vasopressin of plasma-membrane Ca2+ inflow in hepatocytes. Biochem J. 1987 Dec 15;248(3):911–918. doi: 10.1042/bj2480911. [DOI] [PMC free article] [PubMed] [Google Scholar]
  81. Hughes B. P., Milton S. E., Barritt G. J. Effects of vasopressin and La3+ on plasma-membrane Ca2+ inflow and Ca2+ disposition in isolated hepatocytes. Evidence that vasopressin inhibits Ca2+ disposition. Biochem J. 1986 Sep 15;238(3):793–800. doi: 10.1042/bj2380793. [DOI] [PMC free article] [PubMed] [Google Scholar]
  82. Irvine R. F. Inositol phosphates and Ca2+ entry: toward a proliferation or a simplification? FASEB J. 1992 Sep;6(12):3085–3091. doi: 10.1096/fasebj.6.12.1325932. [DOI] [PubMed] [Google Scholar]
  83. Jelinek L. J., Lok S., Rosenberg G. B., Smith R. A., Grant F. J., Biggs S., Bensch P. A., Kuijper J. L., Sheppard P. O., Sprecher C. A. Expression cloning and signaling properties of the rat glucagon receptor. Science. 1993 Mar 12;259(5101):1614–1616. doi: 10.1126/science.8384375. [DOI] [PubMed] [Google Scholar]
  84. Jenkinson D. H., Koller K. Interactions between the effects of alpha- and beta-adrenoceptor agonists and adenine nucleotides on the membrane potential of cells in guinea-pig liver slices. Br J Pharmacol. 1977 Jan;59(1):163–175. doi: 10.1111/j.1476-5381.1977.tb06991.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  85. Joseph S. K., Coll K. E., Thomas A. P., Rubin R., Williamson J. R. The role of extracellular Ca2+ in the response of the hepatocyte to Ca2+-dependent hormones. J Biol Chem. 1985 Oct 15;260(23):12508–12515. [PubMed] [Google Scholar]
  86. Jouneaux C., Audigier Y., Goldsmith P., Pecker F., Lotersztajn S. Gs mediates hormonal inhibition of the calcium pump in liver plasma membranes. J Biol Chem. 1993 Feb 5;268(4):2368–2372. [PubMed] [Google Scholar]
  87. Kaibuchi K., Takai Y., Ogawa Y., Kimura S., Nishizuka Y., Nakamura T., Tomomura A., Ichihara A. Inhibitory action of adenosine 3',5'-monophosphate on phosphatidylinositol turnover: difference in tissue response. Biochem Biophys Res Commun. 1982 Jan 15;104(1):105–112. doi: 10.1016/0006-291x(82)91946-5. [DOI] [PubMed] [Google Scholar]
  88. Kaler K. V., Jones T. B. Dielectrophoretic spectra of single cells determined by feedback-controlled levitation. Biophys J. 1990 Feb;57(2):173–182. doi: 10.1016/S0006-3495(90)82520-0. [DOI] [PMC free article] [PubMed] [Google Scholar]
  89. Kass G. E., Llopis J., Chow S. C., Duddy S. K., Orrenius S. Receptor-operated calcium influx in rat hepatocytes. Identification and characterization using manganese. J Biol Chem. 1990 Oct 15;265(29):17486–17492. [PubMed] [Google Scholar]
  90. Keppens S., De Wulf H. Vasopressin and angiotensin control the activity of liver phosphodiesterase. Biochem J. 1984 Aug 15;222(1):277–280. doi: 10.1042/bj2220277. [DOI] [PMC free article] [PubMed] [Google Scholar]
  91. Keppens S., Vandenheede J. R., De Wulf H. On the role of calcium as second messenger in liver for the hormonally induced activation of glycogen phosphorylase. Biochim Biophys Acta. 1977 Feb 28;496(2):448–457. doi: 10.1016/0304-4165(77)90327-0. [DOI] [PubMed] [Google Scholar]
  92. Keppens S., de Wulf H. The nature of the hepatic receptors involved in vasopressin-induced glycogenolysis. Biochim Biophys Acta. 1979 Nov 15;588(1):63–69. doi: 10.1016/0304-4165(79)90371-4. [DOI] [PubMed] [Google Scholar]
  93. Kimura S., Kugai N., Tada R., Kojima I., Abe K., Ogata E. Sources of calcium mobilized by alpha-adrenergic stimulation in perfused rat liver. Horm Metab Res. 1982 Mar;14(3):133–138. doi: 10.1055/s-2007-1018947. [DOI] [PubMed] [Google Scholar]
  94. Kleineke J., Söling H. D. Mitochondrial and extramitochondrial Ca2+ pools in the perfused rat liver. Mitochondria are not the origin of calcium mobilized by vasopressin. J Biol Chem. 1985 Jan 25;260(2):1040–1045. [PubMed] [Google Scholar]
  95. Kraus-Friedmann N. Effects of glucagon and vasopressin on hepatic Ca2+ release. Proc Natl Acad Sci U S A. 1986 Dec;83(23):8943–8946. doi: 10.1073/pnas.83.23.8943. [DOI] [PMC free article] [PubMed] [Google Scholar]
  96. LEHNINGER A. L. Role of metal ions in enzyme systems. Physiol Rev. 1950 Jul;30(3):393–429. doi: 10.1152/physrev.1950.30.3.393. [DOI] [PubMed] [Google Scholar]
  97. Lehninger A. L., Carafoli E., Rossi C. S. Energy-linked ion movements in mitochondrial systems. Adv Enzymol Relat Areas Mol Biol. 1967;29:259–320. doi: 10.1002/9780470122747.ch6. [DOI] [PubMed] [Google Scholar]
  98. Lin S. H., Wallace M. A., Fain J. N. Regulation of Ca2+-Mg2+-ATPase activity in hepatocyte plasma membranes by vasopressin and phenylephrine. Endocrinology. 1983 Dec;113(6):2268–2275. doi: 10.1210/endo-113-6-2268. [DOI] [PubMed] [Google Scholar]
  99. Llopis J., Kass G. E., Gahm A., Orrenius S. Evidence for two pathways of receptor-mediated Ca2+ entry in hepatocytes. Biochem J. 1992 May 15;284(Pt 1):243–247. doi: 10.1042/bj2840243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  100. Lotersztajn S., Epand R., Mallat A., Pavoine C., Pecker F. The liver plasma membrane Ca2+ pump: hormonal sensitivity. Biochimie. 1985 Oct-Nov;67(10-11):1169–1176. doi: 10.1016/s0300-9084(85)80116-4. [DOI] [PubMed] [Google Scholar]
  101. Lotersztajn S., Hanoune J., Pecker F. A high affinity calcium-stimulated magnesium-dependent ATPase in rat liver plasma membranes. Dependence of an endogenous protein activator distinct from calmodulin. J Biol Chem. 1981 Nov 10;256(21):11209–11215. [PubMed] [Google Scholar]
  102. Lotersztajn S., Pavoine C., Deterre P., Capeau J., Mallat A., LeNguyen D., Dufour M., Rouot B., Bataille D., Pecker F. Role of G protein beta gamma subunits in the regulation of the plasma membrane Ca2+ pump. J Biol Chem. 1992 Feb 5;267(4):2375–2379. [PubMed] [Google Scholar]
  103. Mauger J. P., Claret M. Calcium channels in hepatocytes. J Hepatol. 1988 Oct;7(2):278–282. doi: 10.1016/s0168-8278(88)80492-6. [DOI] [PubMed] [Google Scholar]
  104. Mauger J. P., Claret M. Mobilization of intracellular calcium by glucagon and cyclic AMP analogues in isolated rat hepatocytes. FEBS Lett. 1986 Jan 20;195(1-2):106–110. doi: 10.1016/0014-5793(86)80140-5. [DOI] [PubMed] [Google Scholar]
  105. Mauger J. P., Claret M., Pietri F., Hilly M. Hormonal regulation of inositol 1,4,5-trisphosphate receptor in rat liver. J Biol Chem. 1989 May 25;264(15):8821–8826. [PubMed] [Google Scholar]
  106. Mauger J. P., Poggioli J., Claret M. Synergistic stimulation of the Ca2+ influx in rat hepatocytes by glucagon and the Ca2+-linked hormones vasopressin and angiotensin II. J Biol Chem. 1985 Sep 25;260(21):11635–11642. [PubMed] [Google Scholar]
  107. Mauger J. P., Poggioli J., Guesdon F., Claret M. Noradrenaline, vasopressin and angiotensin increase Ca2+ influx by opening a common pool of Ca2+ channels in isolated rat liver cells. Biochem J. 1984 Jul 1;221(1):121–127. doi: 10.1042/bj2210121. [DOI] [PMC free article] [PubMed] [Google Scholar]
  108. McKinney J. S., Desole M. S., Rubin R. P. Convergence of cAMP and phosphoinositide pathways during rat parotid secretion. Am J Physiol. 1989 Oct;257(4 Pt 1):C651–C657. doi: 10.1152/ajpcell.1989.257.4.C651. [DOI] [PubMed] [Google Scholar]
  109. Michell R. H. Inositol lipids in cellular signalling mechanisms. Trends Biochem Sci. 1992 Aug;17(8):274–276. doi: 10.1016/0968-0004(92)90433-a. [DOI] [PubMed] [Google Scholar]
  110. Michell R. H. Inositol phospholipids and cell surface receptor function. Biochim Biophys Acta. 1975 Mar 25;415(1):81–47. doi: 10.1016/0304-4157(75)90017-9. [DOI] [PubMed] [Google Scholar]
  111. Milligan G. Multiple heterotrimeric guanine nucleotide binding proteins: roles in the determination of cellular signalling specificity. Biochem Soc Trans. 1992 Feb;20(1):135–140. doi: 10.1042/bst0200135. [DOI] [PubMed] [Google Scholar]
  112. Mine T., Kojima I., Ogata E. Evidence of cyclic AMP-independent action of glucagon on calcium mobilization in rat hepatocytes. Biochim Biophys Acta. 1988 Jun 30;970(2):166–171. doi: 10.1016/0167-4889(88)90175-9. [DOI] [PubMed] [Google Scholar]
  113. Mine T., Kojima I., Ogata E. Sources of calcium mobilized by glucagon in isolated rat hepatocytes. Acta Endocrinol (Copenh) 1988 Oct;119(2):301–306. doi: 10.1530/acta.0.1190301. [DOI] [PubMed] [Google Scholar]
  114. Morgan N. G., Blackmore P. F., Exton J. H. Modulation of the alpha 1-adrenergic control of hepatocyte calcium redistribution by increases in cyclic AMP. J Biol Chem. 1983 Apr 25;258(8):5110–5116. [PubMed] [Google Scholar]
  115. Morgan N. G., Charest R., Blackmore P. F., Exton J. H. Potentiation of alpha 1-adrenergic responses in rat liver by a cAMP-dependent mechanism. Proc Natl Acad Sci U S A. 1984 Jul;81(13):4208–4212. doi: 10.1073/pnas.81.13.4208. [DOI] [PMC free article] [PubMed] [Google Scholar]
  116. Nathanson M. H., Moyer M. S., Burgstahler A. D., O'Carroll A. M., Brownstein M. J., Lolait S. J. Mechanisms of subcellular cytosolic Ca2+ signaling evoked by stimulation of the vasopressin V1a receptor. J Biol Chem. 1992 Nov 15;267(32):23282–23289. [PubMed] [Google Scholar]
  117. Neher E. Cell physiology. Controls on calcium influx. Nature. 1992 Jan 23;355(6358):298–299. doi: 10.1038/355298a0. [DOI] [PubMed] [Google Scholar]
  118. Newsholme E. A., Crabtree B. Substrate cycles in metabolic regulation and in heat generation. Biochem Soc Symp. 1976;(41):61–109. [PubMed] [Google Scholar]
  119. Pittner R. A., Fain J. N. Activation of membrane protein kinase C by glucagon and Ca(2+)-mobilizing hormones in cultured rat hepatocytes. Role of phosphatidylinositol and phosphatidylcholine hydrolysis. Biochem J. 1991 Jul 15;277(Pt 2):371–378. doi: 10.1042/bj2770371. [DOI] [PMC free article] [PubMed] [Google Scholar]
  120. Pittner R. A., Fain J. N. Exposure of cultured hepatocytes to cyclic AMP enhances the vasopressin-mediated stimulation of inositol phosphate production. Biochem J. 1989 Jan 15;257(2):455–460. doi: 10.1042/bj2570455. [DOI] [PMC free article] [PubMed] [Google Scholar]
  121. Poggioli J., Berthon B., Claret M. Calcium movements in in situ mitochondria following activation of alpha-adrenergic receptors in rat liver cells. FEBS Lett. 1980 Jun 30;115(2):243–246. doi: 10.1016/0014-5793(80)81178-1. [DOI] [PubMed] [Google Scholar]
  122. Poggioli J., Mauger J. P., Claret M. Effect of cyclic AMP-dependent hormones and Ca2+-mobilizing hormones on the Ca2+ influx and polyphosphoinositide metabolism in isolated rat hepatocytes. Biochem J. 1986 May 1;235(3):663–669. doi: 10.1042/bj2350663. [DOI] [PMC free article] [PubMed] [Google Scholar]
  123. Prpić V., Blackmore P. F., Exton J. H. Phosphatidylinositol breakdown induced by vasopressin and epinephrine in hepatocytes is calcium-dependent. J Biol Chem. 1982 Oct 10;257(19):11323–11331. [PubMed] [Google Scholar]
  124. Prpić V., Spencer T. L., Bygrave F. L. Stable enhancement of calcium retention in mitochondria isolated from rat liver after the administration of glucagon to the intact animal. Biochem J. 1978 Dec 15;176(3):705–714. doi: 10.1042/bj1760705. [DOI] [PMC free article] [PubMed] [Google Scholar]
  125. Putney J. W., Jr Capacitative calcium entry revisited. Cell Calcium. 1990 Nov-Dec;11(10):611–624. doi: 10.1016/0143-4160(90)90016-n. [DOI] [PubMed] [Google Scholar]
  126. Rashed H. M., Patel T. B. Glucagon-stimulated calcium efflux in the isolated perfused rat liver is dependent on cellular redox potential. J Biol Chem. 1987 Nov 25;262(33):15953–15958. [PubMed] [Google Scholar]
  127. Rasmussen H., Barrett P. Q. Calcium messenger system: an integrated view. Physiol Rev. 1984 Jul;64(3):938–984. doi: 10.1152/physrev.1984.64.3.938. [DOI] [PubMed] [Google Scholar]
  128. Rasmussen H. Cell communication, calcium ion, and cyclic adenosine monophosphate. Science. 1970 Oct 23;170(3956):404–412. doi: 10.1126/science.170.3956.404. [DOI] [PubMed] [Google Scholar]
  129. Reinhart P. H., Bygrave F. L. Glucagon stimulation of ruthenium red-insensitive calcium ion transport in developing rat liver. Biochem J. 1981 Feb 15;194(2):541–549. doi: 10.1042/bj1940541. [DOI] [PMC free article] [PubMed] [Google Scholar]
  130. Reinhart P. H., Taylor W. M., Bygrave F. L. Calcium ion fluxes induced by the action of alpha-adrenergic agonists in perfused rat liver. Biochem J. 1982 Dec 15;208(3):619–630. doi: 10.1042/bj2080619. [DOI] [PMC free article] [PubMed] [Google Scholar]
  131. Reinhart P. H., Taylor W. M., Bygrave F. L. The action of alpha-adrenergic agonists on plasma-membrane calcium fluxes in perfused rat liver. Biochem J. 1984 May 15;220(1):43–50. doi: 10.1042/bj2200043. [DOI] [PMC free article] [PubMed] [Google Scholar]
  132. Reinhart P. H., Taylor W. M., Bygrave F. L. The contribution of both extracellular and intracellular calcium to the action of alpha-adrenergic agonists in perfused rat liver. Biochem J. 1984 May 15;220(1):35–42. doi: 10.1042/bj2200035. [DOI] [PMC free article] [PubMed] [Google Scholar]
  133. Reinhart P. H., van de Pol E., Taylor W. M., Bygrave F. L. An assessment of the calcium content of rat liver mitochondria in vivo. Biochem J. 1984 Mar 1;218(2):415–420. doi: 10.1042/bj2180415. [DOI] [PMC free article] [PubMed] [Google Scholar]
  134. Ringer S. A further Contribution regarding the influence of the different Constituents of the Blood on the Contraction of the Heart. J Physiol. 1883 Jan;4(1):29–42.3. doi: 10.1113/jphysiol.1883.sp000120. [DOI] [PMC free article] [PubMed] [Google Scholar]
  135. Rizzuto R., Simpson A. W., Brini M., Pozzan T. Rapid changes of mitochondrial Ca2+ revealed by specifically targeted recombinant aequorin. Nature. 1992 Jul 23;358(6384):325–327. doi: 10.1038/358325a0. [DOI] [PubMed] [Google Scholar]
  136. Rusinko N., Lee H. C. Widespread occurrence in animal tissues of an enzyme catalyzing the conversion of NAD+ into a cyclic metabolite with intracellular Ca2+-mobilizing activity. J Biol Chem. 1989 Jul 15;264(20):11725–11731. [PubMed] [Google Scholar]
  137. Sammak P. J., Adams S. R., Harootunian A. T., Schliwa M., Tsien R. Y. Intracellular cyclic AMP not calcium, determines the direction of vesicle movement in melanophores: direct measurement by fluorescence ratio imaging. J Cell Biol. 1992 Apr;117(1):57–72. doi: 10.1083/jcb.117.1.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
  138. Sanchez-Bueno A., Cobbold P. H. Agonist-specificity in the role of Ca(2+)-induced Ca2+ release in hepatocyte Ca2+ oscillations. Biochem J. 1993 Apr 1;291(Pt 1):169–172. doi: 10.1042/bj2910169. [DOI] [PMC free article] [PubMed] [Google Scholar]
  139. Sanchez-Bueno A., Marrero I., Cobbold P. H. Different modulatory effects of elevated cyclic AMP on cytosolic Ca2+ spikes induced by phenylephrine or vasopressin in single rat hepatocytes. Biochem J. 1993 Apr 1;291(Pt 1):163–168. doi: 10.1042/bj2910163. [DOI] [PMC free article] [PubMed] [Google Scholar]
  140. Sawanobori T., Takanashi H., Hiraoka M., Iida Y., Kamisaka K., Maezawa H. Electrophysiological properties of isolated rat liver cells. J Cell Physiol. 1989 Jun;139(3):580–585. doi: 10.1002/jcp.1041390318. [DOI] [PubMed] [Google Scholar]
  141. Schöfl C., Sanchez-Bueno A., Brabant G., Cobbold P. H., Cuthbertson K. S. Frequency and amplitude enhancement of calcium transients by cyclic AMP in hepatocytes. Biochem J. 1991 Feb 1;273(Pt 3):799–802. doi: 10.1042/bj2730799. [DOI] [PMC free article] [PubMed] [Google Scholar]
  142. Sies H., Graf P., Crane D. Decreased flux through pyruvate dehydrogenase during calcium ion movements induced by vasopressin, alpha-adrenergic agonists and the ionophore A23187 in perfused rat liver. Biochem J. 1983 May 15;212(2):271–278. doi: 10.1042/bj2120271. [DOI] [PMC free article] [PubMed] [Google Scholar]
  143. Sies H., Graf P., Estrela J. M. Hepatic calcium efflux during cytochrome P-450-dependent drug oxidations at the endoplasmic reticulum in intact liver. Proc Natl Acad Sci U S A. 1981 Jun;78(6):3358–3362. doi: 10.1073/pnas.78.6.3358. [DOI] [PMC free article] [PubMed] [Google Scholar]
  144. Simon M. I., Strathmann M. P., Gautam N. Diversity of G proteins in signal transduction. Science. 1991 May 10;252(5007):802–808. doi: 10.1126/science.1902986. [DOI] [PubMed] [Google Scholar]
  145. Sistare F. D., Picking R. A., Haynes R. C., Jr Sensitivity of the response of cytosolic calcium in Quin-2-loaded rat hepatocytes to glucagon, adenine nucleosides, and adenine nucleotides. J Biol Chem. 1985 Oct 15;260(23):12744–12747. [PubMed] [Google Scholar]
  146. Soboll S., Sies H. Effects of hormones on mitochondrial processes. Methods Enzymol. 1989;174:118–130. doi: 10.1016/0076-6879(89)74014-3. [DOI] [PubMed] [Google Scholar]
  147. Somogyi R., Stucki J. W. Hormone-induced calcium oscillations in liver cells can be explained by a simple one pool model. J Biol Chem. 1991 Jun 15;266(17):11068–11077. [PubMed] [Google Scholar]
  148. Somogyi R., Zhao M., Stucki J. W. Modulation of cytosolic-[Ca2+] oscillations in hepatocytes results from cross-talk among second messengers. The synergism between the alpha 1-adrenergic response, glucagon and cyclic AMP, and their antagonism by insulin and diacylglycerol manifest themselves in the control of the cytosolic-[Ca2+] oscillations. Biochem J. 1992 Sep 15;286(Pt 3):869–877. doi: 10.1042/bj2860869. [DOI] [PMC free article] [PubMed] [Google Scholar]
  149. Staddon J. M., Hansford R. G. 4 beta-Phorbol 12-myristate 13-acetate attenuates the glucagon-induced increase in cytoplasmic free Ca2+ concentration in isolated rat hepatocytes. Biochem J. 1986 Sep 15;238(3):737–743. doi: 10.1042/bj2380737. [DOI] [PMC free article] [PubMed] [Google Scholar]
  150. Staddon J. M., Hansford R. G. Evidence indicating that the glucagon-induced increase in cytoplasmic free Ca2+ concentration in hepatocytes is mediated by an increase in cyclic AMP concentration. Eur J Biochem. 1989 Jan 15;179(1):47–52. doi: 10.1111/j.1432-1033.1989.tb14519.x. [DOI] [PubMed] [Google Scholar]
  151. Studer R. K., Snowdowne K. W., Borle A. B. Regulation of hepatic glycogenolysis by glucagon in male and female rats. Role of cAMP and Ca2+ and interactions between epinephrine and glucagon. J Biol Chem. 1984 Mar 25;259(6):3596–3604. [PubMed] [Google Scholar]
  152. Taylor C. W. The role of G proteins in transmembrane signalling. Biochem J. 1990 Nov 15;272(1):1–13. doi: 10.1042/bj2720001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  153. Taylor W. M., Reinhart P. H., Bygrave F. L. Stimulation by alpha-adrenergic agonists of Ca2+ fluxes, mitochondrial oxidation and gluconeogenesis in perfused rat liver. Biochem J. 1983 Jun 15;212(3):555–565. doi: 10.1042/bj2120555. [DOI] [PMC free article] [PubMed] [Google Scholar]
  154. Tennes K. A., McKinney J. S., Putney J. W., Jr Metabolism of inositol 1,4,5-trisphosphate in guinea-pig hepatocytes. Biochem J. 1987 Mar 15;242(3):797–802. doi: 10.1042/bj2420797. [DOI] [PMC free article] [PubMed] [Google Scholar]
  155. Tsien R. Y. Intracellular signal transduction in four dimensions: from molecular design to physiology. Am J Physiol. 1992 Oct;263(4 Pt 1):C723–C728. doi: 10.1152/ajpcell.1992.263.4.C723. [DOI] [PubMed] [Google Scholar]
  156. Tsien R. Y., Pozzan T., Rink T. J. Calcium homeostasis in intact lymphocytes: cytoplasmic free calcium monitored with a new, intracellularly trapped fluorescent indicator. J Cell Biol. 1982 Aug;94(2):325–334. doi: 10.1083/jcb.94.2.325. [DOI] [PMC free article] [PubMed] [Google Scholar]
  157. Unson C. G., Gurzenda E. M., Merrifield R. B. Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist. Peptides. 1989 Nov-Dec;10(6):1171–1177. doi: 10.1016/0196-9781(89)90010-7. [DOI] [PubMed] [Google Scholar]
  158. Vargas A. M., Halestrap A. P., Denton R. M. The effects of glucagon, phenylephrine and insulin on the phosphorylation of cytoplasmic, mitochondrial and membrane-bound proteins of intact liver cells from starved rats. Biochem J. 1982 Oct 15;208(1):221–229. doi: 10.1042/bj2080221. [DOI] [PMC free article] [PubMed] [Google Scholar]
  159. Wakelam M. J., Murphy G. J., Hruby V. J., Houslay M. D. Activation of two signal-transduction systems in hepatocytes by glucagon. Nature. 1986 Sep 4;323(6083):68–71. doi: 10.1038/323068a0. [DOI] [PubMed] [Google Scholar]
  160. Williamson J. R., Cooper R. H., Hoek J. B. Role of calcium in the hormonal regulation of liver metabolism. Biochim Biophys Acta. 1981 Dec 30;639(3-4):243–295. doi: 10.1016/0304-4173(81)90012-4. [DOI] [PubMed] [Google Scholar]
  161. Woods N. M., Cuthbertson K. S., Cobbold P. H. Agonist-induced oscillations in cytoplasmic free calcium concentration in single rat hepatocytes. Cell Calcium. 1987 Feb;8(1):79–100. doi: 10.1016/0143-4160(87)90038-8. [DOI] [PubMed] [Google Scholar]
  162. Woods N. M., Cuthbertson K. S., Cobbold P. H. Repetitive transient rises in cytoplasmic free calcium in hormone-stimulated hepatocytes. Nature. 1986 Feb 13;319(6054):600–602. doi: 10.1038/319600a0. [DOI] [PubMed] [Google Scholar]
  163. Yamaguchi M. Stimulatory effect of calcitonin on Ca2+ inflow in isolated rat hepatocytes. Mol Cell Endocrinol. 1991 Jan;75(1):65–70. doi: 10.1016/0303-7207(91)90246-o. [DOI] [PubMed] [Google Scholar]
  164. van de Werve G., Hue L., Hers H. G. Hormonal and ionic control of the glycogenolytic cascade in rat liver. Biochem J. 1977 Jan 15;162(1):135–142. doi: 10.1042/bj1620135. [DOI] [PMC free article] [PubMed] [Google Scholar]
  165. vom Dahl S., Graf P., Sies H. Hepatic inositol release upon hormonal stimulation of perfused rat liver. Biochem J. 1988 May 1;251(3):843–848. doi: 10.1042/bj2510843. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Biochemical Journal are provided here courtesy of The Biochemical Society

RESOURCES