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. 1994 May 1;299(Pt 3):889–894. doi: 10.1042/bj2990889

Hepatic lipase may act as a ligand in the uptake of artificial chylomicron remnant-like particles by isolated rat hepatocytes.

P Diard 1, M I Malewiak 1, D Lagrange 1, S Griglio 1
PMCID: PMC1138104  PMID: 8192680

Abstract

Active and heat-inactivated hepatic lipase stimulated to a statistically comparable extent the uptake of chylomicron remnant-like particles by isolated rat hepatocytes by 3-fold and 2.3-fold respectively and, likewise, their binding to hepatic plasma membranes by 5-fold and 4-fold respectively. Hepatic lipase may facilitate uptake of these particles, not only as a lipolytic enzyme, but also as a ligand anchored to extracellular glycosaminoglycans.

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Selected References

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