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. 1994 May 15;300(Pt 1):159–164. doi: 10.1042/bj3000159

The analysis of rate limitation within enzymes: relations between flux control coefficients of rate constants and unidirectional rates, rate constants and thermodynamic parameters of single isolated enzymes.

G C Brown 1, C E Cooper 1
PMCID: PMC1138138  PMID: 8198529

Abstract

The extent to which a rate constant or step within an enzyme mechanism limits the net enzyme rate in a particular condition can be quantified as a flux control coefficient. We derive here a number of relations between the control coefficients and the unidirectional rates, rate constants, and thermodynamic parameters of the enzyme. These and other relations are used to suggest a number of methods for experimentally measuring control coefficients within enzymes.

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Selected References

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