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. 1994 Jun 15;300(Pt 3):887–891. doi: 10.1042/bj3000887

Regulation of oxidative degradation of L-lysine in rat liver mitochondria.

P W Scislowski 1, A R Foster 1, M F Fuller 1
PMCID: PMC1138248  PMID: 8010974

Abstract

The generation of 14CO2 from [1-14C]lysine by hepatic mitochondria through the saccharopine pathway is controlled by intramitochondrial concentrations of lysine, 2-oxoglutarate and NADPH. Mitochondria, isolated from rats pre-treated with glucagon, exhibited higher activities of L-lysine: 2-oxoglutarate reductase, saccharopine dehydrogenase and 2-aminoadipate aminotransferase. The flux through this pathway is stimulated in liver mitochondria after glucagon treatment. Multiple regulation of lysine oxidation in liver mitochondria confirms a complex mechanism of 'mitochondrial activation' by glucagon.

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Selected References

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