Figure 4.

Analysis of the publicly available TPE decisions by substance type. (A) Stacked bar plots show the number of substances for which read-across adaptations were accepted or rejected, separated into substance categories. The total number of substances in each category is shown. Within each stacked bar plot, submissions that used analogue (lighter shade) or group (darker shade) read-across are shown. In some instances of rejected read-across, the type of read-across could not be determined (white). (B) For each target substance type, different types of source substances were used as indicated. The outcome of read-across evaluation is shown by the adjacent bars.