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. 1989 Mar 1;258(2):617–620. doi: 10.1042/bj2580617

The mechanism of initiation of lipid peroxidation. Evidence against a requirement for an iron(II)-iron(III) complex.

O I Aruoma 1, B Halliwell 1, M J Laughton 1, G J Quinlan 1, J M Gutteridge 1
PMCID: PMC1138407  PMID: 2706005

Abstract

When Fe2+ ions are added to rat-liver microsomes, lipid peroxidation begins after a short lag period. Fe2+-dependent peroxidation in the first few minutes of the incubation can be increased by adding Fe3+, ascorbic acid or Pb2+ ions; these stimulations are not additive. By contrast, Pb2+ ions inhibit peroxidation of microsomes in the presence of Fe3+/ascorbate or Fe3+-ADP/NADPH. In liposomes made from ox-brain phospholipids, Fe2+-dependent peroxidation is stimulated slightly by Fe3+, but much more so by ascorbic acid, Al3+ or Pb2+; these stimulations are not additive. Liposomal peroxidation in the presence of Fe3+/ascorbate is inhibited by Pb2+ or Al3+. These results argue against the participation of an Fe2+-Fe3+-O2 complex, or a critical 1:1 ratio of Fe2+ to Fe3+, in the initiation of lipid peroxidation in liposomes and rat-liver microsomes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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