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. 2024 Sep 8;16(1):2400414. doi: 10.1080/19420862.2024.2400414

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© 2024 Boehringer Ingelheim. Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 4. — Evaluation of the asymmetrical and symmetrical high-mannose glyco-pair of mAbs regarding their MR interaction. The ConA product pools of three mAbs were analysed by MR-AC. The flow-through peak divided into three parts (F1-F3) and the elution peak (F4) were fractionated as illustrated (a). The fractions were analysed by RPC-MS after Endo F3 digestion leading to the distribution of the asymmetrical and symmetrical high-mannose glyco-pair in each fraction. Data is presented as the average of two MR-AC columns (b–d). The flow-through peak tailing (F3) and the elution peak (F4) were analysed by MR-SPR (e–g).