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. 1989 Apr 15;259(2):609–611. doi: 10.1042/bj2590609

Lack of V1 vasopressin receptors in rabbit hepatocytes.

A Vandekerckhove 1, F Miot 1, S Keppens 1, H De Wulf 1
PMCID: PMC1138554  PMID: 2524192

Abstract

Vasopressin does not induce glycogenolysis in rabbit hepatocytes; glucagon, angiotensin, phenylephrine and ATP are as potent as with rat hepatocytes, whereas isoprenaline is nearly 10000 times more potent in the rabbit. Binding studies of [3H]vasopressin reveal the complete absence of specific vasopressin receptors on rabbit liver plasma membranes. We verified that vasopressin acts as an antidiuretic and vasopressor agent in the rabbit. We conclude that there is a selective lack of V1 vasopressin receptors in rabbit liver.

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Selected References

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