Table 2.

Patient characteristics according to high risk or non high risk status (OlympiA study criteria) in ER-positive (ER+/HER2-) early breast cancer.

Characteristic	High risk (N = 283)		Non high risk (N = 2820)		p value
	N	%	N	%
Age at diagnosis					0.3051
Mean (SD)	62.5 (14.9)		62.0 (12.7)
Median (Min – Max)	63.1 (25–91.6)		62.2 (27.7–95.3)
Menopausal status at diagnosis					0.3404
Menopaused	186	71.0	1955	73.7
Pre-menopaused	76	29.0	697	26.3
Unknown	21		168
Germline BRCA mutation					0.2857a
BRCA1	2	5.4	8	2.6
BRCA2	4	10.8	23	7.4
Undetected	31	83.8	279	90.0
Unknown/not performed	246		2510
Axillary lymph node status (clinical)					<0.0001
Negative	117	41.8	2572	91.5
Positive	163	58.2	238	8.5
Unknown	3		10
Clinical stage (cAJCC)					<0.0001a
0	0	0	5	0.2
IA	53	19.0	2041	74.06
IIA	72	25.8	506	18.4
IIB	82	29.4	139	5.0
IIIA	13	4.6	19	0.7
IIIB	49	17.6	45	1.6
IIIC	10	3.6	1	0.04
Unknown	4		64
Pathological stage (pAJCC)					<0.0001a
0	0	0	10	0.4
IA	2	0.7	1682	60.3
IB	1	0.4	97	3.5
IIA	35	12.4	648	23.2
IIB	38	13.4	279	10.0
IIIA	128	45.2	35	1.26
IIIB	20	7.1	36	1.3
IIIC	59	20.8	1	0.04
Unknown	0		32
Histological subtype					0.0283
Ductal	203	71.7	2197	77.9
Lobular	63	22.3	454	16.1
Other	17	6.0	168	6.0
Unknown	0		1
Tumor grade (SBR)					<0.0001
I	44	15.7	1102	39.6
II	149	53.2	1402	50.3
III	87	31.1	282	10.1
Unknown	3		34
Estrogen receptor expression					1.000a
Positive	282	99.7	2809	99.6
Negative	1	0.3	11	0.4
Progesterone receptor expression					0.1267
Positive	237	83.7	2452	87.0
Negative	46	16.3	367	13.0
Unknown	0		1
HER2 low status					0.0013
0	104	36.8	1319	46.8
Low (1+ ou 2+ without FISH amplification	179	63.2	1501	53.2
Type of breast surgery					<0.0001a
Tumorectomy	83	29.3	2053	72.8
Mastectomy	200	70.7	765	27.1
Axillary lymph node dissection alone	0	0	2	0.1
Type of axillary surgery					<0.0001
Axillary lymph node dissection	236	83.4	887	31.8
Sentinel lymph node dissection	2	0.7	1552	55.7
Both	45	15.9	349	12.5
Unknown	0		32

SD: standard deviation, AJCC: American Joint Committee on Cancer.

^aFisher's exact test.