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. 1986 Nov;39(11):1229–1232. doi: 10.1136/jcp.39.11.1229

Evidence for monoclonal T lymphocyte proliferation in angioimmunoblastic lymphadenopathy.

N T O'Connor, J A Crick, J S Wainscoat, K C Gatter, H Stein, B Falini, D Y Mason
PMCID: PMC1140768  PMID: 3491840

Abstract

The arrangement of the T cell receptor and immunoglobulin genes was analysed in lymphoid tissue biopsy specimens from 25 cases of angioimmunoblastic lymphadenopathy. Nineteen cases showed a rearrangement of the gene coding for the beta chain of the T cell receptor, and in one case a clonal rearrangement of immunoglobulin genes was shown (in which the T cell receptor gene was in a germline configuration). These findings indicate that a monoclonal T cell proliferation is present in most cases of angioimmunoblastic lymphadenopathy, and they also correlate with the fact that some patients who present with this disorder subsequently develop a T cell lymphoma.

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Selected References

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