Fig. 6.

Dyrk1b inhibition moderately ameliorates systemic glucose homeostasis. (a) Experimental designs following DMSO or AZ191 administration of female C57 mice. (b) Insulin tolerance test of mice treated with AZ191 or DMSO (n = 6). (c) Intraperitoneal glucose tolerance test of mice treated with AZ191 or DMSO (n = 7). (d-h) Plasma AST, TG, TC, HDL-C, and LDL-C of mice treated with AZ191 or DMSO (n = 7). Unpaired Student's t-test (two-sided) was performed for Fig. 6b–h. (i–k) Western blot and densitometry quantification of p-Akt in livers of mice treated with AZ191 or DMSO (n = 3). Unpaired Student's t-test (two-sided) was performed for Fig. 6j and k. *P < 0.05, **P < 0.01, ***P < 0.001, n.s., not significant.