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. 1987 Mar;40(3):247–250. doi: 10.1136/jcp.40.3.247

Selective peripheral blood eosinophilia associated with survival advantage in Hodgkin's disease (BNLI Report No 31). British National Lymphoma Investigation.

B Vaughan Hudson, D C Linch, E A Macintyre, M H Bennett, K A MacLennan, G Vaughan Hudson, A M Jelliffe
PMCID: PMC1140892  PMID: 3558857

Abstract

A peripheral blood eosinophilia was found at presentation in 193 of 1260 (15%) patients with Hodgkin's disease who had been entered into clinical studies by the British National Lymphoma Investigation (BNLI). Eosinophilia as a component of a general leucocytosis conferred no survival advantage. Eosinophilia without a general leucocytosis was present in 95 patients, and this selective eosinophilia was associated with a clear survival advantage. The association of selective eosinophilia and improved survival was limited to patients with mixed cellularity and grade I nodular sclerosis histology. Selective eosinophilia was found to be a good prognostic indicator both in local and generalised disease. Its survival advantage seemed to lie in the response to second line treatment following relapse.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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