Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1987 May;40(5):518–523. doi: 10.1136/jcp.40.5.518

Hereditary angioedema and thyroid autoimmunity.

M F Muhlemann, K D Macrae, A M Smith, P Beck, I Hine, U Hegde, A Milford-Ward, G D Carter, P H Wise, J J Cream
PMCID: PMC1141016  PMID: 3584502

Abstract

Sera from 91 patients with hereditary angioedema were screened for thyroid antibodies. The results for the 77 patients more than 17 years old were compared with previously published data for the prevalence of thyroid disease in a large community (Whickham). Of the female patients with hereditary angioedema, the prevalence of thyroglobulin antibodies (TGA) was 14.0%, higher than the expected 3% (p less than 0.001). The prevalence of thyroid microsomal antibodies (TMA) was 20%, also higher than the expected 7.6% (p less than 0.01). The age distributions of the females in both groups differed: in the group with hereditary angioedema there was a greater proportion of younger patients which should have resulted in a lower prevalence of thyroid antibodies. Adjusting for related patients with hereditary angioedema, there was still an increased prevalence of TGA (p less than 0.01) and TMA (p less than 0.01).

Full text

PDF
518

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Donaldson V. H., Hess E. V., McAdams A. J. Lupus-erythematosus-like disease in three unrelated women with hereditary angioneurotic edema. Ann Intern Med. 1977 Mar;86(3):312–313. doi: 10.7326/0003-4819-86-3-312. [DOI] [PubMed] [Google Scholar]
  2. Hall R., Dingle P. R., Roberts D. F. Thyroid antibodies: a study of first degree relatives. Clin Genet. 1972;3(5):319–324. doi: 10.1111/j.1399-0004.1972.tb01463.x. [DOI] [PubMed] [Google Scholar]
  3. Hory B., Panouse-Perrin J., Suzuki Y., Faivre R., Saint-Hillier Y., Coulon G., Leibowitch J. Néphropathie à complexes immuns et déficit héréditaire en inhibiteur de la C1 estérase. Nouv Presse Med. 1981 Jun 13;10(26):2193–2196. [PubMed] [Google Scholar]
  4. Kohler P. F., Percy J., Campion W. M., Smyth C. J. Hereditary angioedema and "familial" lupus erythematosus in identical twin boys. Am J Med. 1974 Mar;56(3):406–411. doi: 10.1016/0002-9343(74)90623-8. [DOI] [PubMed] [Google Scholar]
  5. Lachmann P. J. Inherited complement deficiencies. Philos Trans R Soc Lond B Biol Sci. 1984 Sep 6;306(1129):419–430. doi: 10.1098/rstb.1984.0102. [DOI] [PubMed] [Google Scholar]
  6. Massa M. C., Connolly S. M. An association between C1 esterase inhibitor deficiency and lupus erythematosus: report of two cases and review of the literature. J Am Acad Dermatol. 1982 Aug;7(2):255–264. doi: 10.1016/s0190-9622(82)70115-x. [DOI] [PubMed] [Google Scholar]
  7. Pickering R. J., Michael A. F., Jr, Herdman R. C., Good R. A., Gewurz H. The complement system in chronic glomerulonephritis: three newly associated aberrations. J Pediatr. 1971 Jan;78(1):30–43. doi: 10.1016/s0022-3476(71)80261-5. [DOI] [PubMed] [Google Scholar]
  8. Plaza J., Malasit P., Kerr D. N. Hereditary angio-oedema with mesangiocapillary glomerulonephritis. Postgrad Med J. 1977 Oct;53(624):627–630. doi: 10.1136/pgmj.53.624.627. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Robson E. B., Lachmann P. J., Hobart M. J., Johnston A. W. Linkage studies in hereditary angio-oedema. J Med Genet. 1979 Oct;16(5):347–350. doi: 10.1136/jmg.16.5.347. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Seignalet C., Berthoux F., Seignalet J., Michel F. B. Hereditary angio-oedema and C3 nephritic factor--HL-A study. Clin Allergy. 1979 Sep;9(5):527–533. doi: 10.1111/j.1365-2222.1979.tb02517.x. [DOI] [PubMed] [Google Scholar]
  11. Tuffanelli D. L. Discoid lupus erythematosus and the variant form of hereditary angioedema. Arch Dermatol. 1977 Mar;113(3):374–375. doi: 10.1001/archderm.1977.01640030120024. [DOI] [PubMed] [Google Scholar]
  12. Tunbridge W. M., Evered D. C., Hall R., Appleton D., Brewis M., Clark F., Evans J. G., Young E., Bird T., Smith P. A. The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol (Oxf) 1977 Dec;7(6):481–493. doi: 10.1111/j.1365-2265.1977.tb01340.x. [DOI] [PubMed] [Google Scholar]
  13. Young D. W., Thompson R. A., Mackie P. H. Plasmapheresis in hereditary angioneurotic edema and systemic lupus erythematosus. Arch Intern Med. 1980 Jan;140(1):127–128. [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES