Abstract
Of the 123 patients with acute mesenteric infarction treated over the past 12 years, 16 (13%) had mesenteric venous thrombosis. Eight of the patients with mesenteric venous thrombosis survived the initial episode; two have since died. The remaining six patients were studied for evidence of haemostatic deficiencies or abnormalities. Antithrombin III deficiency, which is known to be associated with recurrent venous thrombosis, was found in three patients. It is recommended that all patients with mesenteric venous thrombosis should be screened for antithrombin III deficiency as treatment with coumarin anticoagulants may be indicated, providing effective prophylaxis against further thrombotic episodes.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Abildgaard U., Lie M., Odegård O. R. Antithrombin (heparin cofactor) assay with "new" chromogenic substrates (S-2238 and Chromozym TH). Thromb Res. 1977 Oct;11(4):549–553. doi: 10.1016/0049-3848(77)90208-0. [DOI] [PubMed] [Google Scholar]
- Aoki N., Moroi M., Sakata Y., Yoshida N., Matsuda M. Abnormal plasminogen. A hereditary molecular abnormality found in a patient with recurrent thrombosis. J Clin Invest. 1978 May;61(5):1186–1195. doi: 10.1172/JCI109034. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Comp P. C., Nixon R. R., Cooper M. R., Esmon C. T. Familial protein S deficiency is associated with recurrent thrombosis. J Clin Invest. 1984 Dec;74(6):2082–2088. doi: 10.1172/JCI111632. [DOI] [PMC free article] [PubMed] [Google Scholar]
- EGEBERG O. INHERITED ANTITHROMBIN DEFICIENCY CAUSING THROMBOPHILIA. Thromb Diath Haemorrh. 1965 Jun 15;13:516–530. [PubMed] [Google Scholar]
- Friberger P., Knös M., Gustavsson S., Aurell L., Claeson G. Methods for determination of plasmin, antiplasmin and plasminogen by means of substrate S-2251. Haemostasis. 1978;7(2-3):138–145. doi: 10.1159/000214252. [DOI] [PubMed] [Google Scholar]
- Griffin J. H., Evatt B., Zimmerman T. S., Kleiss A. J., Wideman C. Deficiency of protein C in congenital thrombotic disease. J Clin Invest. 1981 Nov;68(5):1370–1373. doi: 10.1172/JCI110385. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gruenberg J. C., Smallridge R. C., Rosenberg R. D. Inherited antithrombin-III deficiency causing mesenteric venous infarction: a new clinical entity. Ann Surg. 1975 Jun;181(6):791–794. doi: 10.1097/00000658-197506000-00004. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Horellou M. H., Conard J., Bertina R. M., Samama M. Congenital protein C deficiency and thrombotic disease in nine French families. Br Med J (Clin Res Ed) 1984 Nov 10;289(6454):1285–1287. doi: 10.1136/bmj.289.6454.1285. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mannucci P. M., Boyer C., Wolf M., Tripodi A., Larrieu M. J. Treatment of congenital antithrombin III deficiency with concentrates. Br J Haematol. 1982 Mar;50(3):531–535. doi: 10.1111/j.1365-2141.1982.tb01949.x. [DOI] [PubMed] [Google Scholar]
- Ottinger L. W., Austen W. G. A study of 136 patients with mesenteric infarction. Surg Gynecol Obstet. 1967 Feb;124(2):251–261. [PubMed] [Google Scholar]
- Thaler E., Lechner K. Antithrombin III deficiency and thromboembolism. Clin Haematol. 1981 Jun;10(2):369–390. [PubMed] [Google Scholar]
- Winter J. H., Fenech A., Ridley W., Bennett B., Cumming A. M., Mackie M., Douglas A. S. Familial antithrombin III deficiency. Q J Med. 1982;51(204):373–395. [PubMed] [Google Scholar]