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. 1987 Sep;40(9):959–970. doi: 10.1136/jcp.40.9.959

Molecular pathology of single gene disorders.

D J Weatherall 1
PMCID: PMC1141165  PMID: 3312305

Abstract

Recent studies using recombinant DNA technology have led to an understanding of the basic molecular pathology of single gene disorders. Furthermore, methods are being developed for finding genes for conditions, whose underlying biochemistry is still not understood, or which may contribute to polygenic systems that underlie common diseases. As well as providing new approaches to carrier detection, prenatal diagnosis, and treatment of single gene disorders, these advances promise to provide important information about the pathophysiology of many common polygenic diseases.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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